Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1993 Apr;108(4):1016–1023. doi: 10.1111/j.1476-5381.1993.tb13499.x

Enhancement of airway reactivity to histamine by isoprenaline and related beta-adrenoceptor agonists in the guinea-pig.

B C Galland 1, J G Blackman 1
PMCID: PMC1908158  PMID: 8097949

Abstract

1. The effect of isoprenaline, adrenaline and salbutamol on airway reactivity to histamine was observed in anaesthetized, ventilated guinea-pigs. Airway reactivity was determined before and 20 min and 90 min after a 30-min i.v. infusion of each agonist by constructing cumulative dose-response curves from breath-by-breath measurements of the effect of different rates of i.v. infusion of histamine on lung resistance (RL) and dynamic compliance (Cdyn). 2. (+/-)-Isoprenaline infused i.v. for 30 min at a rate of 0.4 mumol h-1 kg-1 caused bronchodilatation and a fall in blood pressure. Recovery to starting values of RL and Cdyn occurred within 20 min of stopping the infusion. 3. Reactivity to histamine was greatly enhanced when measured 20 min and 90 min after stopping the infusion of (+/- )-isoprenaline. This was not an effect of the prior infusion of histamine or of the dissolving solution. 4. Infusion of (-)-isoprenaline for 30 min at a rate of 0.2 mumol h-1 kg-1 also enhanced reactivity to histamine. However, enhancement of reactivity to histamine was not demonstrable after infusion of (+)-isoprenaline at equal or higher dose rates. 5. Infusions of bronchodilator concentrations of adrenaline and salbutamol also enhanced airway reactivity to histamine, but the bronchodilator effect of salbutamol lasted longer than that of isoprenaline or adrenaline and the development of hyperreactivity was delayed. 6. After acute bilateral vagotomy, infusion of (+/- )-isoprenaline enhanced airway reactivity but only at the highest dose of histamine. 7. (+/-)-Isoprenaline did not enhance contractile responses to histamine in isolated preparations of first branch bronchi.(ABSTRACT TRUNCATED AT 250 WORDS)

Full text

PDF
1018

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMDUR M. O., MEAD J. Mechanics of respiration in unanesthetized guinea pigs. Am J Physiol. 1958 Feb;192(2):364–368. doi: 10.1152/ajplegacy.1958.192.2.364. [DOI] [PubMed] [Google Scholar]
  2. Conolly M. E., Davies D. S., Dollery C. T., George C. F. Resistance to -adrenoceptor stimulants (a possible explanation for the rise in ashtma deaths). Br J Pharmacol. 1971 Oct;43(2):389–402. [PMC free article] [PubMed] [Google Scholar]
  3. Crane J., Pearce N., Flatt A., Burgess C., Jackson R., Kwong T., Ball M., Beasley R. Prescribed fenoterol and death from asthma in New Zealand, 1981-83: case-control study. Lancet. 1989 Apr 29;1(8644):917–922. doi: 10.1016/s0140-6736(89)92505-1. [DOI] [PubMed] [Google Scholar]
  4. Edelstein P. H., Meyer R. D., Finegold S. M. Laboratory diagnosis of Legionnaires' disease. Am Rev Respir Dis. 1980 Feb;121(2):317–327. doi: 10.1164/arrd.1980.121.2.317. [DOI] [PubMed] [Google Scholar]
  5. Eisenstadt W. S., Nicholas S. S. The adverse effect of adrenergic aerosols in bronchial asthma. Ann Allergy. 1969 Jun;27(6):283–288. [PubMed] [Google Scholar]
  6. Hooker C. S., Calkins P. J., Fleisch J. H. On the measurement of vascular and respiratory smooth muscle responses in vitro. Blood Vessels. 1977;14(1):1–11. doi: 10.1159/000158110. [DOI] [PubMed] [Google Scholar]
  7. Izard S. R., Henson E. C., Collins A. D., Brunson J. G. Increased sensitivity to anaphylactic shock in guinea pigs induced by prolonged treatment with epinephrine prior to challenge. J Allergy. 1971 Jun;47(6):309–314. doi: 10.1016/s0091-6749(71)80134-3. [DOI] [PubMed] [Google Scholar]
  8. Keighley J. F. Iatrogenic asthma associated with adrenergic aerosols. Ann Intern Med. 1966 Nov;65(5):985–995. doi: 10.7326/0003-4819-65-5-985. [DOI] [PubMed] [Google Scholar]
  9. Kerrebijn K. F., van Essen-Zandvliet E. E., Neijens H. J. Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol. 1987 Apr;79(4):653–659. doi: 10.1016/s0091-6749(87)80163-x. [DOI] [PubMed] [Google Scholar]
  10. Kraan J., Koëter G. H., vd Mark T. W., Sluiter H. J., de Vries K. Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline. J Allergy Clin Immunol. 1985 Oct;76(4):628–636. doi: 10.1016/0091-6749(85)90786-9. [DOI] [PubMed] [Google Scholar]
  11. Morley J., Sanjar S., Newth C. Viewpoint: untoward effects of beta-adrenoceptor agonists in asthma. Eur Respir J. 1990 Feb;3(2):228–233. [PubMed] [Google Scholar]
  12. Paterson J. W., Evans R. J., Prime F. J. SElectivity of broncholidlator action of salbutamol in asthmatic patients. Br J Dis Chest. 1971 Jan;65(1):21–38. [PubMed] [Google Scholar]
  13. Reisman R. E. Asthma induced by adrenergic aerosols. J Allergy. 1970 Sep;46(3):162–177. doi: 10.1016/0021-8707(70)90095-x. [DOI] [PubMed] [Google Scholar]
  14. Sanjar S., Kristersson A., Mazzoni L., Morley J., Schaeublin E. Increased airway reactivity in the guinea-pig follows exposure to intravenous isoprenaline. J Physiol. 1990 Jun;425:43–54. doi: 10.1113/jphysiol.1990.sp018091. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sears M. R., Taylor D. R., Print C. G., Lake D. C., Li Q. Q., Flannery E. M., Yates D. M., Lucas M. K., Herbison G. P. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet. 1990 Dec 8;336(8728):1391–1396. doi: 10.1016/0140-6736(90)93098-a. [DOI] [PubMed] [Google Scholar]
  16. Spitzer W. O., Suissa S., Ernst P., Horwitz R. I., Habbick B., Cockcroft D., Boivin J. F., McNutt M., Buist A. S., Rebuck A. S. The use of beta-agonists and the risk of death and near death from asthma. N Engl J Med. 1992 Feb 20;326(8):501–506. doi: 10.1056/NEJM199202203260801. [DOI] [PubMed] [Google Scholar]
  17. Van Metre T. E., Jr Adverse effects of inhalation of excessive amounts of nebulized isoproterenol in status asthmaticus. J Allergy. 1969 Feb;43(2):101–113. doi: 10.1016/0021-8707(69)90130-0. [DOI] [PubMed] [Google Scholar]
  18. Vathenen A. S., Knox A. J., Higgins B. G., Britton J. R., Tattersfield A. E. Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline. Lancet. 1988 Mar 12;1(8585):554–558. doi: 10.1016/s0140-6736(88)91352-9. [DOI] [PubMed] [Google Scholar]
  19. van Schayck C. P., Graafsma S. J., Visch M. B., Dompeling E., van Weel C., van Herwaarden C. L. Increased bronchial hyperresponsiveness after inhaling salbutamol during 1 year is not caused by subsensitization to salbutamol. J Allergy Clin Immunol. 1990 Nov;86(5):793–800. doi: 10.1016/s0091-6749(05)80185-x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES