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. 1992 Jan;105(1):3–5. doi: 10.1111/j.1476-5381.1992.tb14199.x

The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro.

K D Keegan 1, G N Woodruff 1, R D Pinnock 1
PMCID: PMC1908621  PMID: 1375857

Abstract

Intra- and extracellular recordings were made from substantia nigra zona compacta neurones from an in vitro rat brain slice preparation. A subpopulation of dopamine-sensitive neurones were encountered which were potently excited by bath application of the NK3 receptor agonist, senktide. On these senktide-sensitive neurones, NK1 and NK2 receptor agonists were inactive. The excitatory action of senktide supports a role for tachykinins as putative neurotransmitters in the basal ganglia.

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Selected References

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