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. 1995 Aug;115(8):1347–1348. doi: 10.1111/j.1476-5381.1995.tb16622.x

Lens opacification by antioestrogens: tamoxifen vs ICI 182,780.

J J Zhang 1, T J Jacob 1, S P Hardy 1, C F Higgins 1, M A Valverde 1
PMCID: PMC1908879  PMID: 8564190

Abstract

The antioestrogen, tamoxifen, blocks volume-regulated chloride channels and reduces transparency in bovine lenses maintained in vitro. In contrast to tamoxifen, the steroidal antioestrogen, ICI 182780, did not block volume-regulated chloride currents in three cultured cell lines and required 10 fold higher concentration to induce significant opacification of bovine lenses maintained in vitro. These data suggest that ocular toxic side effects will be minimized by use of the steroidal (ICI 182780) rather than nonsteroidal antioestrogens (tamoxifen).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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