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. 1996 Jan;117(1):130–132. doi: 10.1111/j.1476-5381.1996.tb15164.x

The dose-related effects of paracetamol on hyperalgesia and nociception in the rat.

M Bianchi 1, A E Panerai 1
PMCID: PMC1909387  PMID: 8825353

Abstract

1. We have studied the effects of 3 low doses of paracetamol (25, 50 and 100 mg kg-1 p.o.) on inflammatory hyperalgesia, inflammatory oedema, and nociceptive thresholds in rats. 2. At the lower dose (25 mg kg-1), paracetamol reduces only central hyperalgesia. 3. At the doses of 50 and 100 mg kg-1, paracetamol reduces also peripheral hyperalgesia; moreover, it enhances nociceptive thresholds to a mechanical stimulus in the non-inflamed paws. 4. Neither paw inflammatory oedema nor tail nociceptive thresholds to a thermal stimulus were modified by paracetamol administration. 5. Our results suggest that paracetamol can reduce hyperalgesia without affecting physiological nociception and inflammation.

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Selected References

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