Abstract
In view of increased susceptibility to tuberculosis in protein malnutrition, the phenomenon of accelerated granulomatous response by the macrophage was studied in rabbits immunized and subsequently challenged with BCG. Dietary protein depletion resulted in marked retardation of macrophage mobilization and granuloma formation in various organs. The granulomatous index was low in most organs. The granulomas were few, small, abortive and ill-formed by loosely knit epithelioid cells and giant cells. This deficiency of macrophage function might limit the effectiveness of BCG vaccination in the malnourished host.
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- Alleyne G. A., Young V. H. Adrenal function in malnutrition. Lancet. 1966 Apr 23;1(7443):911–912. doi: 10.1016/s0140-6736(66)91584-4. [DOI] [PubMed] [Google Scholar]
- Bhuyan U. N., Ramalingaswami V. Immune responses of the protein-deficient guinea pig to BCG vaccination. Am J Pathol. 1973 Sep;72(3):489–502. [PMC free article] [PubMed] [Google Scholar]
- David J. R., David R. R. Cellular hypersensitivity and immunity. Inhibition of macrophage migration and the lymphocyte mediators. Prog Allergy. 1972;16:300–449. [PubMed] [Google Scholar]
- Epstein W. L., Krasnobrod H. The origin of epithelioid cells in experimental granulomas of man. Lab Invest. 1968 Feb;18(2):190–195. [PubMed] [Google Scholar]
- KAWATA H., MYRVIK Q. N., LEAKE E. S. DISSOCIATION OF TUBERCULIN HYPERSENSITIVITY AS MEDIATOR FOR AN ACCELERATED PULMONARY GRANULOMATOUS RESPONSE IN RABBITS. J Immunol. 1964 Sep;93:433–438. [PubMed] [Google Scholar]
- MYRVIK Q. N., LEAKE E. S., OSHIMA S. A study of macrophages and epitheloid-like cells from granulomatous (BCG-induced) lungs of rabbits. J Immunol. 1962 Nov;89:745–751. [PubMed] [Google Scholar]
- Mackaness G. B. The immunology of antituberculous immunity. Am Rev Respir Dis. 1968 Mar;97(3):337–344. doi: 10.1164/arrd.1968.97.3.337. [DOI] [PubMed] [Google Scholar]
- OSHIMA S., MYRVIK Q. N., LEAKE E. The demonstration of lysozyme as a dominant tuberculostatic factor in extracts of granulomatous lungs. Br J Exp Pathol. 1961 Apr;42:138–144. [PMC free article] [PubMed] [Google Scholar]
- Sutton J. S., Weiss L. Transformation of monocytes in tissue culture into macrophages, epithelioid cells, and multinucleated giant cells. An electron microscope study. J Cell Biol. 1966 Feb;28(2):303–332. doi: 10.1083/jcb.28.2.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Youmans G. P., Youmans A. S. Recent studies on acquired immunity in tuberculosis. Curr Top Microbiol Immunol. 1969;48:129–178. doi: 10.1007/978-3-642-46163-7_6. [DOI] [PubMed] [Google Scholar]