The nuclear membranes in hypertrophied human cardiac muscle cells.

Abstract

Nuclear membranes of cardiac muscle cells were studied in 134 patients with cardiac hypertrophy of various causes. Abnormalities observed consisted of: a) increased foldings and convolutions; b) nuclear pseudoinclusions formed by cytoplasmic organelles protruding into saccular invaginations of the nuclear membranes, and c) intranuclear tubules. The increased foldings and convolutions of the nuclear membranes and the nuclear pseudoinclusions appear to result from synthesis of nuclear membranes in excess of that needed to accommodate the increase in nuclear volume which occurs in hypertrophy. Intranuclear tubules were found in 6 patients and consisted of tubular invaginations, 400 to 650 A in diameter, of the inner nuclear membranes into the nucleoplasm. Some of these tubules were straight and cylindrical, and were associated with a peripheral layer of marginated chromatin; others were not associated with chromatin, appeared coiled and followed irregular courses. Intranuclear tubules in cardiac muscle cells probably represent an extreme cellular response to the stimulus of hypertrophy.

Full text

PDF

• Previous
• 427
• …
• 456
• 457
• 458
• 459
• 460
• Next

Images in this article

Fig 21
on p.460

Fig 11
on p.452

Fig 12
on p.453

Fig 13
on p.454

Fig 14
on p.455

Fig 1
on p.447

Fig 15
on p.456

Fig 2
on p.448

Figs 3 and 4
on p.448

Fig 5
on p.448

Fig 16
on p.457

Fig 17
on p.457

Fig 6
on p.449

Fig 18
on p.458

Fig 7
on p.451

Fig 8
on p.451

Fig 9
on p.451

Fig 10
on p.451

Fig 19
on p.459

Fig 20
on p.459