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. 1975 Jul;80(1):153–162.

Immunopathologic and morphologic studies of skeletal muscle in Chagas' disease.

R P Laguens, P M Cossio, C Diez, A Segal, C Vasquez, E Kreutzer, E Khoury, R M Arana
PMCID: PMC1912837  PMID: 125546

Abstract

Skeletal muscle biopsies from 21 individuals infected with Trypanosoma cruzi were studied my means of immunofluorescence, ultrastructural immunochemical, light and electron microscopic, and histochemical procedures. In 12 cases, definite morphologic alterations were found. These alterations were coincident with the presence of circulating antibodies against the plasma membrane of striated muscle fibers and endothelial cells (EVI antibodies). In almost all cases the lesions also presented autologous immunoglobulins bound to the plasma membrane of muscle fibers and endothelial cells. Interstitial inflammatory exudate was not observed in the diseased muscle. On the basis of these observations, it is suggested that the EVI antibody is related to some of the pathogenetic mechanism of skeletal muscle damage in Chagas' disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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