Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1975 Aug;80(2):329–340.

Immune complex type glomerulonephritis in cirrhosis of the liver.

P Callard, G Feldmann, D Prandi, M F Belair, C Mandet, Y Weiss, P Druet, J P Benhamou, J Bariety
PMCID: PMC1912920  PMID: 126021

Abstract

Glomerular lesions were detected in 9 of 10 patients with liver cirrhosis: these lesions consisted of a) thickening of basement-membrane-like material, b) electron-dense deposits in mesangial areas and in capillary walls, c) round areas of rarefaction in the membrane-like material and in some deposits, and d) presence of IgA, with IgG and/or IgM and/or C3, in the deposits. The association of these four abnormalities seems to be characteristic of "cirrhotic glomerulonephritis." The deposits could be the result of precipitation in the glomeruli of either aggregated immunoglobulins or circulating immune complexes.

Full text

PDF
329

Images in this article

339Figure 1
on p.339
340Figure 2
on p.340
340Figure 3
on p.340
340Figure 4
on p.340

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALDUS W. P., FEICHTER R. N., SUMMERSKILL W. H. THE KIDNEY IN CIRRHOSIS. I. CLINICAL AND BIOCHEMICAL FEATURES OF AZOTEMIA IN HEPATIC FAILURE. Ann Intern Med. 1964 Mar;60:353–365. doi: 10.7326/0003-4819-60-3-353. [DOI] [PubMed] [Google Scholar]
  2. BISMUTH H., BERTHELOT P., DESBUQUOIS B., BENHAMOU J. P., FAUVERT R. L'ANASTOMOSE PORTO-CAVE EXP'ERIMENTALE CHEZ LE RAT NORMAL. ETUDE DE QUELQUES ANOMALIES BIOLOGIQUES. Rev Fr Etud Clin Biol. 1964 Jun-Jul;9:608–613. [PubMed] [Google Scholar]
  3. BLOODWORTH J. M., Jr, SOMMERS S. C. "Cirrhotic glomerulosclerosis," a renal lesion associated with hepatic cirrhosis. Lab Invest. 1959 Sep-Oct;8:962–978. [PubMed] [Google Scholar]
  4. Bariéty J., Druet P., Loirat P., Lagrue G. Les glomérulonéphrites pariétoprolifératives. (G.N.P.P.) Etude histopathologique en microscopie optique, électronique et en immunohistochimie de 49 cas. Corrélations anatomocliniques. Pathol Biol (Paris) 1971 Mar;19(5):259–283. [PubMed] [Google Scholar]
  5. Bariéty J., Druet P. Résultats de l'immunohistochemie de 589 biopsies rénales (transplantés axclus) Ann Med Interne (Paris) 1971 Jan;122(1):63–69. [PubMed] [Google Scholar]
  6. Berger J., Hinglais N. Les ddpôts intercapillaires d'IgA-IgG. J Urol Nephrol (Paris) 1968 Sep;74(9):694–695. [PubMed] [Google Scholar]
  7. Berger J. IgA glomerular deposits in renal disease. Transplant Proc. 1969 Dec;1(4):939–944. [PubMed] [Google Scholar]
  8. Bjorneboe M., Prytz H., Orskov F. Antibodies to intestinal microbes in serum of patients with cirrhosis of the liver. Lancet. 1972 Jan 8;1(7741):58–60. doi: 10.1016/s0140-6736(72)90060-8. [DOI] [PubMed] [Google Scholar]
  9. Dixon F. J. The pathogenesis of glomerulonephritis. Am J Med. 1968 Apr;44(4):493–498. doi: 10.1016/0002-9343(68)90050-8. [DOI] [PubMed] [Google Scholar]
  10. Druet P., Bariety J., Bernard D., Lagrue G. Les glomérulopathies primitives a dépots mésangiaux d'IgA et D'IgG. Etude clinique et morphologiaue de 52 cas. Presse Med. 1970 Mar 14;78(13):583–587. [PubMed] [Google Scholar]
  11. Druet P., Letonturier P., Contet A., Mandet C. Cryoglobulinaemia in human renal diseases. A study of seventy-six cases. Clin Exp Immunol. 1973 Dec;15(4):483–496. [PMC free article] [PubMed] [Google Scholar]
  12. Fisher E. R., Perez-Stable E. Cirrhotic (hepatic) lobular glomerulonephritis. Correlation of ultrastructural and clinical features. Am J Pathol. 1968 Apr;52(4):869–889. [PMC free article] [PubMed] [Google Scholar]
  13. Grieco M. H., Capra J. D., Paderon H. Reduced serum beta 1c/1a globulin levels in extrarenal disease. Am J Med. 1971 Sep;51(3):340–345. doi: 10.1016/0002-9343(71)90269-5. [DOI] [PubMed] [Google Scholar]
  14. JONES W. A., RAO D. R., BRAUNSTIN H. The renal glomerulus in cirrhosis of the liver. Am J Pathol. 1961 Oct;39:393–404. [PMC free article] [PubMed] [Google Scholar]
  15. Kourilsky O., Leroy C., Peltier A. P. Complement and liver cell function in 53 patients with liver disease. Am J Med. 1973 Dec;55(6):783–790. doi: 10.1016/0002-9343(73)90259-3. [DOI] [PubMed] [Google Scholar]
  16. Leber P. D., McCluskey R. T. Complement and the immunohistology of renal disease. Transplant Proc. 1974 Mar;6(1):67–76. [PubMed] [Google Scholar]
  17. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  18. Manigand G., Morel-Maroger L., Simon J., Deparis M. Lésions rénales glomérulaires et cirrhose du foie. Note préliminaire sur les lésions histologiques du rein au cours des cirrhoses hépatiques, d'après 20 prélèvements biopsiques. Rev Eur Etud Clin Biol. 1970 Nov;15(9):989–996. [PubMed] [Google Scholar]
  19. Michael A. F., Fish A. J., Good R. A. Glomerular localization and transport of aggregated proteins in mice. Lab Invest. 1967 Jul;17(1):14–29. [PubMed] [Google Scholar]
  20. Nowoslawski A., Krawczyński K., Brzosko W. J., Madaliński K. Tissue localization of Australia antigen immune complexes in acute and chronic hepatitis and liver cirrhosis. Am J Pathol. 1972 Jul;68(1):31–56. [PMC free article] [PubMed] [Google Scholar]
  21. PATEK A. J., Jr, SEEGAL D., BEVANS M. The coexistence of cirrhosis of the liver and glomerulonephritis; report of 14 cases. Am J Med Sci. 1951 Jan;221(1):77–85. doi: 10.1097/00000441-195101000-00011. [DOI] [PubMed] [Google Scholar]
  22. Perrin L. H., Lambert P. H., Nydegger U. E., Miescher P. A. Quantitation of C3PA (properdin factor B) and other complement components in diseases associated with a low C3 level. Clin Immunol Immunopathol. 1973 Nov;2(1):16–27. doi: 10.1016/0090-1229(73)90032-9. [DOI] [PubMed] [Google Scholar]
  23. Peters D. K., Charlesworth J. A., Sissons J. G., Williams D. G., Boulton-Jones J. M., Evans D. J., Kourilsky O., Morel-Maroger L. Mesangiocapillary nephritis, partial lipodystrophy, and hypocomplementaemia. Lancet. 1973 Sep 8;2(7828):535–538. doi: 10.1016/s0140-6736(73)92351-9. [DOI] [PubMed] [Google Scholar]
  24. RAPHAEL S. S., LYNCH M. J. Kimmelstiel-Wilson glomerulonephropathy; its occurrence in diseases other than diabetes mellitus. AMA Arch Pathol. 1958 Apr;65(4):420–431. [PubMed] [Google Scholar]
  25. SAKAGUCHI H., DACHS S., GRISHMAN E., PARONETTO F., SALOMON M., CHURG J. HEPATIC GLOMERULOSCLEROSIS. AN ELECTRON MICROSCOPIC STUDY OF RENAL BIOPSIES IN LIVER DISEASES. Lab Invest. 1965 May;14:533–545. [PubMed] [Google Scholar]
  26. SALOMON M. I., SAKAGUCHI H., CHURG J., DACHS S., GRISHMAN E., MAUTNER W., PARONETTO F., ROSENTHAL W. S. RENAL LESIONS IN HEPATIC DISEASE: A STUDY BASED ON KIDNEY BIOPSIES. Arch Intern Med. 1965 Jun;115:704–709. doi: 10.1001/archinte.1960.03860180076013. [DOI] [PubMed] [Google Scholar]
  27. TOMASI T. B., Jr, TISDALE W. A. SERUM GAMMA-GLOBULINS IN ACUTE AND CHRONIC LIVER DISEASES. Nature. 1964 Feb 22;201:834–835. doi: 10.1038/201834a0. [DOI] [PubMed] [Google Scholar]
  28. Triger D. R., Alp M. H., Wright R. Bacterial and dietary antibodies in liver disease. Lancet. 1972 Jan 8;1(7741):60–63. doi: 10.1016/s0140-6736(72)90061-x. [DOI] [PubMed] [Google Scholar]
  29. Triger D. R., MacCallum F. O., Kurtz J. B., Wright R. Raised antibody titres to measles and rubella viruses in chronic active hepatitis. Lancet. 1972 Mar 25;1(7752):665–667. doi: 10.1016/s0140-6736(72)90465-5. [DOI] [PubMed] [Google Scholar]
  30. Triger D. R., Wright R. Hyperglobulinaemia in liver disease. Lancet. 1973 Jun 30;1(7818):1494–1496. doi: 10.1016/s0140-6736(73)91827-8. [DOI] [PubMed] [Google Scholar]
  31. Triger D. R., Wright R. Studies on hepatic uptake of antigen. II. The effect of hepatotoxins on the immune response. Immunology. 1973 Dec;25(6):951–956. [PMC free article] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES