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. 1996 Nov;119(6):1081–1083. doi: 10.1111/j.1476-5381.1996.tb16007.x

Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices.

B Nicol 1, D G Lambert 1, D J Rowbotham 1, D Smart 1, A T McKnight 1
PMCID: PMC1915895  PMID: 8937708

Abstract

Nociceptin, an endogenous ligand for the orphan receptor ORL1, has recently been described. In this study we have shown that nociception inhibits 46 mM K(+)-stimulated glutamate release from rat perfused cerebrocortical slices with an IC50 of 51 nM. At 100 nM the inhibition amounted to 68 +/- 14% and was naloxone (10 microM)-insensitive excluding an activation of mu, delta and kappa opioid receptors. These data demonstrate the functional coupling of ORL1 in glutamatergic neurones and implicates a role for nociceptin in glutamatergic neurotransmission.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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