Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1982 May;107(2):212–218.

Frequency and distribution of papillomavirus structural antigens in verrucae, multiple papillomas, and condylomata of the oral cavity.

A B Jenson, W D Lancaster, D P Hartmann, E L Shaffer Jr
PMCID: PMC1916006  PMID: 6282128

Abstract

Sixty-seven proliferous squamous epithelial lesions of the oral cavity were examined for the presence of human papillomavirus whole (structural) virion antigens by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific (common) antigens of the papillomaviruses. A positive reaction for papillomavirus genus specific antigens was found in 18 of 29 verrucae, 2 of 5 multiple papillomas, and 3 of 5 condylomata; common antigens were not detected in 28 keratoacanthomas. The positive reaction was invariably intranuclear in cells having a focal or diffuse distribution in the superficial epithelium. This study shows that a variety of squamous epithelial lesions of the mucosa are associated with human papillomaviruses and suggests that these viruses may play an important role in the etiology of some cases of squamous hyperplasia of the oral cavity.

Full text

PDF
215

Images in this article

214Figure 1
on p.214
215Figure 2
on p.215
216Figure 3
on p.216
217Figure 4
on p.217

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyle W. F., Riggs J. L., Oshiro L. S., Lennette E. H. Electron microscopic identification of papova virus in laryngeal papilloma. Laryngoscope. 1973 Jul;83(7):1102–1108. doi: 10.1288/00005537-197307000-00013. [DOI] [PubMed] [Google Scholar]
  2. Butel J. S. Studies with human papilloma virus modeled after known papovavirus systems. J Natl Cancer Inst. 1972 Feb;48(2):285–299. [PubMed] [Google Scholar]
  3. Costa J., Howley P. M., Bowling M. C., Howard R., Bauer W. C. Presence of human papilloma viral antigens in juvenile multiple laryngeal papilloma. Am J Clin Pathol. 1981 Feb;75(2):194–197. doi: 10.1093/ajcp/75.2.194. [DOI] [PubMed] [Google Scholar]
  4. Frithiof L., Wersäll J. Virus-like particles in papillomas of the human oral cavity. Arch Gesamte Virusforsch. 1967;21(1):31–44. doi: 10.1007/BF01258474. [DOI] [PubMed] [Google Scholar]
  5. Jenson A. B., Rosenthal J. D., Olson C., Pass F., Lancaster W. D., Shah K. Immunologic relatedness of papillomaviruses from different species. J Natl Cancer Inst. 1980 Mar;64(3):495–500. [PubMed] [Google Scholar]
  6. Koller L. D., Olson C. Attempted transmission of warts from man, cattle, and horses and of deer fibroma, to selected hosts. J Invest Dermatol. 1972 Jun;58(6):366–368. doi: 10.1111/1523-1747.ep12540579. [DOI] [PubMed] [Google Scholar]
  7. Kurman R. J., Shah K. H., Lancaster W. D., Jenson A. B. Immunoperoxidase localization of papillomavirus antigens in cervical dysplasia and vulvar condylomas. Am J Obstet Gynecol. 1981 Aug 15;140(8):931–935. doi: 10.1016/0002-9378(81)90087-9. [DOI] [PubMed] [Google Scholar]
  8. Lack E. E., Jenson A. B., Smith H. G., Healy G. B., Pass F., Vawter G. F. Immunoperoxidase localization of human papillomavirus in laryngeal papillomas. Intervirology. 1980;14(3-4):148–154. doi: 10.1159/000149176. [DOI] [PubMed] [Google Scholar]
  9. Lack E. E., Vawter G. F., Smith H. G., Healy G. B., Lancaster W. D., Jenson A. B. Immunohistochemical localisation of human papillomavirus in squamous papillomas of the larynx. Lancet. 1980 Sep 13;2(8194):592–592. doi: 10.1016/s0140-6736(80)92027-9. [DOI] [PubMed] [Google Scholar]
  10. Lancaster W. D., Jenson A. B. Evidence for papillomavirus genus-specific antigens and DNA in laryngeal papilloma. Intervirology. 1981;15(4):204–212. doi: 10.1159/000149233. [DOI] [PubMed] [Google Scholar]
  11. Lancaster W. D., Olson C. Demonstration of two distinct classes of bovine papilloma virus. Virology. 1978 Sep;89(2):372–379. doi: 10.1016/0042-6822(78)90179-4. [DOI] [PubMed] [Google Scholar]
  12. Melnick J. L., Allison A. C., Butel J. S., Eckhart W., Eddy B. E., Kit S., Levine A. J., Miles J. A., Pagano J. S., Sachs L. Papovaviridae. Intervirology. 1974;3(1-2):106–120. doi: 10.1159/000149746. [DOI] [PubMed] [Google Scholar]
  13. OLSON C. CUTANEOUS PAPILLOMATOSIS IN CATTLE AND OTHER ANIMALS. Ann N Y Acad Sci. 1963 Nov 4;108:1042–1056. doi: 10.1111/j.1749-6632.1963.tb13435.x. [DOI] [PubMed] [Google Scholar]
  14. Praetorius-Clausen F. Rare oral viral disorders (molluscum contagiosum, localized keratoacanthoma, verrucae, condyloma acuminatum, and focal epithelial hyperplasia). Oral Surg Oral Med Oral Pathol. 1972 Oct;34(4):604–618. doi: 10.1016/0030-4220(72)90344-1. [DOI] [PubMed] [Google Scholar]
  15. Praetorius-Clausen F., Willis J. M. Papova virus-like particles in focal epithelial hyperplasia. Scand J Dent Res. 1971;79(5):362–365. doi: 10.1111/j.1600-0722.1971.tb02022.x. [DOI] [PubMed] [Google Scholar]
  16. Rowson K. E., Mahy B. W. Human papova (wart) virus. Bacteriol Rev. 1967 Jun;31(2):110–131. doi: 10.1128/br.31.2.110-131.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Shaffer E. L., Jr, Reimann B. E., Gysland W. B. Oral condyloma acuminatum. A case report with light microscopic and ultrastructural features. J Oral Pathol. 1980 May;9(3):163–173. doi: 10.1111/j.1600-0714.1980.tb00373.x. [DOI] [PubMed] [Google Scholar]
  18. Spoendlin H., Kistler G. Papova-virus in human laryngeal papillomas. Arch Otorhinolaryngol. 1978 Jan 30;218(3-4):289–292. doi: 10.1007/BF00455564. [DOI] [PubMed] [Google Scholar]
  19. Van Wyk C. W., Staz J., Farman A. G. Focal epithelial hyperplasia in a group of South Africans: Its ultrastructural features. J Oral Pathol. 1977 Jan;6(1):14–24. doi: 10.1111/j.1600-0714.1977.tb01790.x. [DOI] [PubMed] [Google Scholar]
  20. Wysocki G. P., Hardie J. Ultrastructural studies of intraoral verruca vulgaris. Oral Surg Oral Med Oral Pathol. 1979 Jan;47(1):58–62. doi: 10.1016/0030-4220(79)90102-6. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES