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. 1982 Sep;108(3):319–365.

Autoimmune diseases: immunopathology and etiopathogenesis.

A N Theofilopoulos, F J Dixon
PMCID: PMC1916035  PMID: 7051837

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdou N. I., Lindsley H. B., Pollock A., Stechschulte D. J., Wood G. Plasmapheresis in active systemic lupus erythematosus: effects on clinical, serum, and cellular abnormalities. Case report. Clin Immunol Immunopathol. 1981 Apr;19(1):44–54. doi: 10.1016/0090-1229(81)90046-5. [DOI] [PubMed] [Google Scholar]
  2. Abdou N. I., Sagawa A., Pascual E., Hebert J., Sadeghee S. Suppressor T-cell abnormality in idiopathic systemic lupus erythematosus. Clin Immunol Immunopathol. 1976 Sep;6(2):192–199. doi: 10.1016/0090-1229(76)90110-0. [DOI] [PubMed] [Google Scholar]
  3. Adams D. D., Knight J. G. H gene theory of inherited autoimmune disease. Lancet. 1980 Feb 23;1(8165):396–398. doi: 10.1016/s0140-6736(80)90946-0. [DOI] [PubMed] [Google Scholar]
  4. Adams D. D. Thyroid-stimulating autoantibodies. Vitam Horm. 1980;38:119–203. doi: 10.1016/s0083-6729(08)60485-9. [DOI] [PubMed] [Google Scholar]
  5. Akizuki M., Reeves J. P., Steinberg A. D. Expression of autoimmunity by NZB/NZW marrow. Clin Immunol Immunopathol. 1978 Jul;10(3):247–250. doi: 10.1016/0090-1229(78)90177-0. [DOI] [PubMed] [Google Scholar]
  6. Alarcon-Segovia D., Ruiz-Arguelles A., Fishbein E. Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors. Nature. 1978 Jan 5;271(5640):67–69. doi: 10.1038/271067a0. [DOI] [PubMed] [Google Scholar]
  7. Alarcón-Segovia D., Ruíz-Argüelles A. Decreased circulating thymus-derived cells with receptors for the Fc portion of immunoglobulin G in systemic lupus erythematosus. J Clin Invest. 1978 Dec;62(6):1390–1394. doi: 10.1172/JCI109260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Alevy Y. G., Witherspoon C., Bellone C. J. Anti-TMA immunity in mice. III. Induction of L-tyrosine-p-azophenyltrimethylammonium (tyr(TMA)) specific helper T cells by the monovalent antigen or idiotypic antisera. J Immunol. 1981 Jun;126(6):2390–2396. [PubMed] [Google Scholar]
  9. Alspaugh M. A., Henle G., Lennette E. T., Henle W. Elevated levels of antibodies to Epstein-Barr virus antigens in sera and synovial fluids of patients with rheumatoid arthritis. J Clin Invest. 1981 Apr;67(4):1134–1140. doi: 10.1172/JCI110127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Altman A., Theofilopoulos A. N., Weiner R., Katz D. H., Dixon F. J. Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2. J Exp Med. 1981 Sep 1;154(3):791–808. doi: 10.1084/jem.154.3.791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Amagai T., Cinader B. Resistance of MRL/Mp-lpr/lpr mice to tolerance induction. Eur J Immunol. 1981 Nov;11(11):923–926. doi: 10.1002/eji.1830111113. [DOI] [PubMed] [Google Scholar]
  12. Andersson L. C., Aguet M., Wight E., Andersson R., Binz H., Wigzell H. Induction of specific immune unresponsiveness using purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. I. Demonstration of general validity as to species and histocompatibility barriers. J Exp Med. 1977 Oct 1;146(4):1124–1137. doi: 10.1084/jem.146.4.1124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Andrews B. S., Eisenberg R. A., Theofilopoulos A. N., Izui S., Wilson C. B., McConahey P. J., Murphy E. D., Roths J. B., Dixon F. J. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med. 1978 Nov 1;148(5):1198–1215. doi: 10.1084/jem.148.5.1198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Aoki N., Pinnamaneni K. M., DeGroot L. J. Studies on suppressor cell function in thyroid diseases. J Clin Endocrinol Metab. 1979 May;48(5):803–810. doi: 10.1210/jcem-48-5-803. [DOI] [PubMed] [Google Scholar]
  15. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Actively acquired tolerance of foreign cells. Nature. 1953 Oct 3;172(4379):603–606. doi: 10.1038/172603a0. [DOI] [PubMed] [Google Scholar]
  16. Bach J. F., Dardenne M., Salomon J. C. Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice. Clin Exp Immunol. 1973 Jun;14(2):247–256. [PMC free article] [PubMed] [Google Scholar]
  17. Bach M. A., Bach J. F. The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases. Clin Exp Immunol. 1981 Sep;45(3):449–456. [PMC free article] [PubMed] [Google Scholar]
  18. Barbacid M., Bolognesi D., Aaronson S. A. Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1617–1621. doi: 10.1073/pnas.77.3.1617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Benacerraf B. Role of MHC gene products in immune regulation. Science. 1981 Jun 12;212(4500):1229–1238. doi: 10.1126/science.6165083. [DOI] [PubMed] [Google Scholar]
  20. Berman P. W., Patrick J. Linkage between the frequency of muscular weakness and loci that regulate immune responsiveness in murine experimental myasthenia gravis. J Exp Med. 1980 Sep 1;152(3):507–520. doi: 10.1084/jem.152.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Berrih S., Gaud C., Bach M. A., Le Brigand H., Binet J. P., Bach J. F. Evaluation of T cell subsets in myasthenia gravis using anti-T cell monoclonal antibodies. Clin Exp Immunol. 1981 Jul;45(1):1–8. [PMC free article] [PubMed] [Google Scholar]
  22. Bevan M. J. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature. 1977 Sep 29;269(5627):417–418. doi: 10.1038/269417a0. [DOI] [PubMed] [Google Scholar]
  23. Bigazzi P. E., Kosuda L. L., Hsu K. C., Andres G. A. Immune complex orchitis in vasectomized rabbits. J Exp Med. 1976 Feb 1;143(2):382–404. doi: 10.1084/jem.143.2.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Binz H., Frischknecht H., Wigzell H. Some studies on idiotypes and anti-idiotypic reactions and receptors in anti-allo-MHC T-cell immunity. Ann Immunol (Paris) 1979 Mar-Apr;130(2):273–279. [PubMed] [Google Scholar]
  25. Bluestein H. G. Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3965–3969. doi: 10.1073/pnas.75.8.3965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Bluestone J. A., Sharrow S. O., Epstein S. L., Ozato K., Sachs D. H. Induction of anti-H-2 antibodies without alloantigen exposure by in vivo administration of anti-idiotype. Nature. 1981 May 21;291(5812):233–235. doi: 10.1038/291233a0. [DOI] [PubMed] [Google Scholar]
  27. Bona C. A., Heber-Katz E., Paul W. E. Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones. J Exp Med. 1981 Apr 1;153(4):951–967. doi: 10.1084/jem.153.4.951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Borel Y., Lewis R. M., André-Schwartz J., Stollar B. D., Diener E. Treatment of lupus nephritis in adult (NZB + NZW)F1 mice by cortisone-facilitated tolerance to nucleic acid antigens. J Clin Invest. 1978 Feb;61(2):276–286. doi: 10.1172/JCI108937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Borel Y., Young M. C. Nucleic acid-specific suppressor T cells. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1593–1596. doi: 10.1073/pnas.77.3.1593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Braverman I. M., Slesinski J. Study of autoimmune disease in New Zealand mice. IV. Immunologic reactivity and reticuloendothelial function. J Invest Dermatol. 1970 Nov;55(5):317–324. doi: 10.1111/1523-1747.ep12260187. [DOI] [PubMed] [Google Scholar]
  31. Brenner T., Abramsky O. Immunosuppression of experimental autoimmune myasthenia gravis by alpha-fetoprotein rich formation. Immunol Lett. 1981 Aug;3(3):163–167. doi: 10.1016/0165-2478(81)90121-8. [DOI] [PubMed] [Google Scholar]
  32. Bresnihan B., Jasin H. E. Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest. 1977 Jan;59(1):106–116. doi: 10.1172/JCI108607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Brewerton D. A. Joseph J. Bunim Memorial Lecture. HLA-B27 and the inheritance of susceptibility to rheumatic disease. Arthritis Rheum. 1976 Jul-Aug;19(4):656–668. doi: 10.1002/1529-0131(197607/08)19:4<656::aid-art1780190402>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  34. Brown C. A., Carey K., Colvin R. B. Inhibition of autoimmune tubulointerstitial nephritis in guinea pigs by heterologous antisera containing anti-idiotype antibodies. J Immunol. 1979 Nov;123(5):2102–2107. [PubMed] [Google Scholar]
  35. Brown J. C., Rodkey L. S. Autoregulation of an antibody response via network-induced auto-anti-idiotype. J Exp Med. 1979 Jul 1;150(1):67–85. doi: 10.1084/jem.150.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Cahill G. F., Jr, McDevitt H. O. Insulin-dependent diabetes mellitus: the initial lesion. N Engl J Med. 1981 Jun 11;304(24):1454–1465. doi: 10.1056/NEJM198106113042403. [DOI] [PubMed] [Google Scholar]
  37. Cantor H., Gershon R. K. Immunological circuits: cellular composition. Fed Proc. 1979 Jun;38(7):2058–2064. [PubMed] [Google Scholar]
  38. Cantor H., McVay-Boudreau L., Hugenberger J., Naidorf K., Shen F. W., Gershon R. K. Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice. J Exp Med. 1978 Apr 1;147(4):1116–1125. doi: 10.1084/jem.147.4.1116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Carson D. A., Pasquali J. L., Tsoukas C. D., Fong S., Slovin S. F., Lawrance S. K., Slaughter L., Vaughan J. H. Physiology and pathology of rheumatoid factors. Springer Semin Immunopathol. 1981;4(2):161–179. doi: 10.1007/BF01857093. [DOI] [PubMed] [Google Scholar]
  40. Catalano M. A., Carson D. A., Slovin S. F., Richman D. D., Vaughan J. H. Antibodies to Epstein-Barr virus-determined antigens in normal subjects and in patients with seropositive rheumatoid arthritis. Proc Natl Acad Sci U S A. 1979 Nov;76(11):5825–5828. doi: 10.1073/pnas.76.11.5825. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Cayre Y., Palladino M. A., Marcu K. B., Stavnezer J. Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3814–3818. doi: 10.1073/pnas.78.6.3814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Cohn D. A. High sensitivity to androgen as a contributing factor in sex differences in the immune response. Arthritis Rheum. 1979 Nov;22(11):1218–1233. doi: 10.1002/art.1780221109. [DOI] [PubMed] [Google Scholar]
  43. Cohn M. Immunology: what are the rules of the game? Cell Immunol. 1972 Sep;5(1):1–20. doi: 10.1016/0008-8749(72)90079-2. [DOI] [PubMed] [Google Scholar]
  44. Cosenza H. Detection of anti-idiotype reactive cells in the response to phosphorylcholine. Eur J Immunol. 1976 Feb;6(2):114–116. doi: 10.1002/eji.1830060208. [DOI] [PubMed] [Google Scholar]
  45. Cosenza H., Köhler H. Specific inhibition of plaque formation to phosphorylcholine by antibody against antibody. Science. 1972 Jun 2;176(4038):1027–1029. doi: 10.1126/science.176.4038.1027. [DOI] [PubMed] [Google Scholar]
  46. Cossio P. M., Diez C., Szarfman A., Kreutzer E., Candiolo B., Arana R. M. Chagasic cardiopathy. Demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures. Circulation. 1974 Jan;49(1):13–21. doi: 10.1161/01.cir.49.1.13. [DOI] [PubMed] [Google Scholar]
  47. Coutinho A. The self-nonself discrimination and the nature and acquisition of the antibody repertoire. Ann Immunol (Paris) 1980 Nov-Dec;131D(3):235–253. [PubMed] [Google Scholar]
  48. Cox K. O., Cox J., Thomas W. R., Watkins M. C. Experimental erythrocyte autoimmunity. I. Mice congenic for immunoglobulin allotypes vary in production of autoantibodies but produce suppressor cells not restricted by allotypes. Immunology. 1980 Jun;40(2):171–176. [PMC free article] [PubMed] [Google Scholar]
  49. Creighton W. D., Katz D. H., Dixon F. J. Antigen-specific immunocompetency, B cell function, and regulatory helper and suppressor T cell activities in spontaneously autoimmune mice. J Immunol. 1979 Dec;123(6):2627–2636. [PubMed] [Google Scholar]
  50. Croce C. M., Shander M., Martinis J., Cicurel L., D'Ancona G. G., Dolby T. W., Koprowski H. Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3416–3419. doi: 10.1073/pnas.76.7.3416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Croker B. P., Jr, del Villano B. C., Jensen F. C., Lerner R. A., Dixon F. J. Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (BALB-c times NZB)F1 mice by Scripps leukemia virus. J Exp Med. 1974 Oct 1;140(4):1028–1048. doi: 10.1084/jem.140.4.1028. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. D'Eustachio P., Bothwell A. L., Takaro T. K., Baltimore D., Ruddle F. H. Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains. J Exp Med. 1981 Apr 1;153(4):793–800. doi: 10.1084/jem.153.4.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. D'Eustachio P., Pravtcheva D., Marcu K., Ruddle F. H. Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains. J Exp Med. 1980 Jun 1;151(6):1545–1550. doi: 10.1084/jem.151.6.1545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Datta S. K., Manny N., Andrzejewski C., André-Schwartz J., Schwartz R. S. Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice I. Xenotropic virus. J Exp Med. 1978 Mar 1;147(3):854–871. doi: 10.1084/jem.147.3.854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Datta S. K., McConahey P. J., Manny N., Theofilopoulos A. N., Dixon F. J., Schwartz R. S. Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice. II. The viral envelope glycoprotein gp70. J Exp Med. 1978 Mar 1;147(3):872–881. doi: 10.1084/jem.147.3.872. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Datta S. K., Schwartz R. S. Genetics of expression of xenotropic virus and autoimmunity in NZB mice. Nature. 1976 Sep 30;263(5576):412–415. doi: 10.1038/263412b0. [DOI] [PubMed] [Google Scholar]
  57. Datta S. K., Schwartz R. S. Mendelian segregation of loci controlling xenotropic virus production in NZB crosses. Virology. 1977 Dec;83(2):449–452. doi: 10.1016/0042-6822(77)90193-3. [DOI] [PubMed] [Google Scholar]
  58. Dauphinée M. J., Kipper S. B., Wofsy D., Talal N. Interleukin 2 deficiency is a common feature of autoimmune mice. J Immunol. 1981 Dec;127(6):2483–2487. [PubMed] [Google Scholar]
  59. Davie J. M. Anti-idiotypic reagents. J Immunol Methods. 1980;38(1-2):1–7. doi: 10.1016/0022-1759(80)90327-0. [DOI] [PubMed] [Google Scholar]
  60. DeHeer D. H., Edgington T. S. Evidence for a B lymphocyte defect underlying the anti-X anti-erythrocyte autoantibody response of NZB mice. J Immunol. 1977 May;118(5):1858–1863. [PubMed] [Google Scholar]
  61. Depper J. M., Zvaifler N. J. Epstein-Barr virus. Its relationship to the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 1981 Jun;24(6):755–761. doi: 10.1002/art.1780240601. [DOI] [PubMed] [Google Scholar]
  62. Doherty P. C., Bennink J. R. Monitoring the integrity of self: biology of MHC-restriction of virus-immune T cells. Fed Proc. 1981 Feb;40(2):218–221. [PubMed] [Google Scholar]
  63. Dresser D. W. Most IgM-producing cells in the mouse secrete auto-antibodies (rheumatoid factor). Nature. 1978 Aug 3;274(5670):480–483. doi: 10.1038/274480a0. [DOI] [PubMed] [Google Scholar]
  64. Eichmann K. Expression and function of idiotypes of lymphocytes. Adv Immunol. 1978;26:195–254. doi: 10.1016/s0065-2776(08)60231-x. [DOI] [PubMed] [Google Scholar]
  65. Eichmann K., Kindt T. J. The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates. J Exp Med. 1971 Aug 1;134(2):532–552. doi: 10.1084/jem.134.2.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Eisenberg R. A., Dixon F. J. Effect of castration on male-determined acceleration of autoimmune disease in BXSB mice. J Immunol. 1980 Nov;125(5):1959–1961. [PubMed] [Google Scholar]
  67. Eisenberg R. A., Izui S., McConahey P. J., Hang L., Peters C. J., Theofilopoulos A. N., Dixon F. J. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol. 1980 Sep;125(3):1032–1036. [PubMed] [Google Scholar]
  68. Eisenberg R. A., Theofilopoulos A. N., Andrews B. S., Peters C. J., Thor L., Dixon F. J. Natural thymocytotoxic autoantibodies in autoimmune and normal mice. J Immunol. 1979 Jun;122(6):2272–2278. [PubMed] [Google Scholar]
  69. Elder J. H., Jensen F. C., Bryant M. L., Lerner R. A. Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family. Nature. 1977 May 5;267(5606):23–28. doi: 10.1038/267023a0. [DOI] [PubMed] [Google Scholar]
  70. Erikson J., Martinis J., Croce C. M. Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. Nature. 1981 Nov 12;294(5837):173–175. doi: 10.1038/294173a0. [DOI] [PubMed] [Google Scholar]
  71. Farid N. R., Newton R. M., Noel E. P., Marshall W. H. Gm phenotypes in autoimmune thyroid disease. J Immunogenet. 1977 Dec;4(6):429–432. doi: 10.1111/j.1744-313x.1977.tb00927.x. [DOI] [PubMed] [Google Scholar]
  72. Farrell C., Bloth B., Nielsen H., Daugharty H., Lundman T., Svehag S. E. A survey for circulating immune complexes in patients with acute myocardial infarction. Use of a C1q-binding assay with soluble protein A as indicator. Scand J Immunol. 1977;6(12):1233–1240. doi: 10.1111/j.1365-3083.1977.tb00362.x. [DOI] [PubMed] [Google Scholar]
  73. Fauci A. S., Steinberg A. D., Haynes B. F., Whalen G. Immunoregulatory aberrations in systemic lupus erythematosus. J Immunol. 1978 Oct;121(4):1473–1479. [PubMed] [Google Scholar]
  74. Feizi T., Taylor-Robinson D., Shields M. D., Carter R. A. Production of cold agglutinins in rabbits immunized with human erythrocytes treated with Mycoplasma pneumoniae. Nature. 1969 Jun 28;222(5200):1253–1256. doi: 10.1038/2221253a0. [DOI] [PubMed] [Google Scholar]
  75. Fernandes G., Yunis E. J., Good R. A. Influence of diet on survival of mice. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1279–1283. doi: 10.1073/pnas.73.4.1279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Ferrell P. B., Aitcheson C. T., Pearson G. R., Tan E. M. Seroepidemiological study of relationships between Epstein-Barr virus and rheumatoid arthritis. J Clin Invest. 1981 Mar;67(3):681–687. doi: 10.1172/JCI110083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Ferrell P. B., Tan E. M. Epstein-Barr (EB) virus antibodies in rheumatoid arthritis. Springer Semin Immunopathol. 1981;4(2):181–191. doi: 10.1007/BF01857094. [DOI] [PubMed] [Google Scholar]
  78. Finbloom D. S., Plotz P. H. Studies of reticuloendothelial function in the mouse with model immune complexes. II. Serum clearance, tissue uptake, and reticuloendothelial saturation in NZB/W mice. J Immunol. 1979 Oct;123(4):1600–1603. [PMC free article] [PubMed] [Google Scholar]
  79. Fish F., Ziff M. The in vitro and in vivo induction of anti-double-stranded DNA antibodies in normal and autoimmune mice. J Immunol. 1982 Jan;128(1):409–414. [PubMed] [Google Scholar]
  80. Flood P. M., Kripke M. L., Rowley D. A., Schreiber H. Suppression of tumor rejection by autologous anti-idiotypic immunity. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2209–2213. doi: 10.1073/pnas.77.4.2209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Fong S., Tsoukas C. D., Frincke L. A., Lawrance S. K., Holbrook T. L., Vaughan J. H., Carson D. A. Age-associated changes in Epstein-Barr virus-induced human lymphocyte autoantibody responses. J Immunol. 1981 Mar;126(3):910–914. [PubMed] [Google Scholar]
  82. Forni L., Coutinho A., Köhler G., Jerne N. K. IgM antibodies induce the production of antibodies of the same specificity. Proc Natl Acad Sci U S A. 1980 Feb;77(2):1125–1128. doi: 10.1073/pnas.77.2.1125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Frank M. M., Hamburger M. I., Lawley T. J., Kimberly R. P., Plotz P. H. Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med. 1979 Mar 8;300(10):518–523. doi: 10.1056/NEJM197903083001002. [DOI] [PubMed] [Google Scholar]
  84. Fraser C. M., Venter J. C., Kaliner M. Autonomic abnormalities and autoantibodies to beta-adrenergic receptors. N Engl J Med. 1981 Nov 12;305(20):1165–1170. doi: 10.1056/NEJM198111123052001. [DOI] [PubMed] [Google Scholar]
  85. Geha R. S. Regulation of the immune response by idiotypic-antiidiotypic interactions. N Engl J Med. 1981 Jul 2;305(1):25–28. doi: 10.1056/NEJM198107023050105. [DOI] [PubMed] [Google Scholar]
  86. Geha R. S., Weinberg R. P. Anti-idiotypic antisera in man. I. Production and immunochemical characterization of anti-idiotypic antisera to human antitetanus antibodies. J Immunol. 1978 Oct;121(4):1518–1523. [PubMed] [Google Scholar]
  87. Gershon R. K., Eardley D. D., Durum S., Green D. R., Shen F. W., Yamauchi K., Cantor H., Murphy D. B. Contrasuppression. A novel immunoregulatory activity. J Exp Med. 1981 Jun 1;153(6):1533–1546. doi: 10.1084/jem.153.6.1533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Gershwin M. E., Ohsugi Y., Ahmed A., Castles J. J., Scibienski R., Ikeda R. M. Studies of congenitally immunologically mutant New Zealand mice. IV. Development of autoimmunity in congenitally athymic (nude) New Zealand Black x White F1 hybrid mice. J Immunol. 1980 Sep;125(3):1189–1195. [PubMed] [Google Scholar]
  89. Gershwin M. E., Steinberg A. D., Ahmed A., Derkay C. Study of thymic factors. II. Failure of thymosin to alter the natural history of NZB and NZB/NZW mice. Arthritis Rheum. 1976 Sep-Oct;19(5):862–866. doi: 10.1002/art.1780190505. [DOI] [PubMed] [Google Scholar]
  90. Glimcher L. H., Longo D. L., Green I., Schwartz R. H. Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules. J Exp Med. 1981 Nov 1;154(5):1652–1670. doi: 10.1084/jem.154.5.1652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Glimcher L. H., Steinberg A. D., House S. B., Green I. The autologous mixed lymphocyte reaction in strains of mice with autoimmune disease. J Immunol. 1980 Oct;125(4):1832–1838. [PubMed] [Google Scholar]
  92. Goidl E. A., Schrater A. F., Siskind G. W., Thorbecke G. J. Production of auto-anti-idiotypic antibody during the normal immune response to TNP-Ficoll. II. Hapten-reversible inhibition of anti-TNP plaque-forming cells by immune serum as an assay for auto-anti-idiotypic antibody. J Exp Med. 1979 Jul 1;150(1):154–165. doi: 10.1084/jem.150.1.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Goldings E. A., Cohen P. L., McFadden S. F., Ziff M., Vitetta E. S. Defective B cell tolerance in adult (NZB X MZW)F1 mice. J Exp Med. 1980 Sep 1;152(3):730–735. doi: 10.1084/jem.152.3.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Golub E. S. Idiotypes and the network hypothesis. Cell. 1980 Dec;22(3):641–642. doi: 10.1016/0092-8674(80)90536-x. [DOI] [PubMed] [Google Scholar]
  95. Golub E. S. Suppressor T cells and their possible role in the regulation of autoreactivity. Cell. 1981 Jun;24(3):595–596. doi: 10.1016/0092-8674(81)90083-0. [DOI] [PubMed] [Google Scholar]
  96. Grausz H., Earley L. E., Stephens B. G., Lee J. C., Hopper J., Jr Diagnostic import of virus-like particles in the glomerular endothelium of patients with systemic lupus erythematosus. N Engl J Med. 1970 Sep 3;283(10):506–511. doi: 10.1056/NEJM197009032831003. [DOI] [PubMed] [Google Scholar]
  97. Green D. R., Gershon R. K., Eardley D. D. Functional deletion of different Ly-1 T-cell-inducer subset activities by Ly-2 suppressor T lymphocytes. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3819–3823. doi: 10.1073/pnas.78.6.3819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Henson J. B., McGuire T. C. Equine infectious anemia. Prog Med Virol. 1974;18(0):143–159. [PubMed] [Google Scholar]
  99. Hiernaux J. Antiidiotypic networks. Fed Proc. 1981 Apr;40(5):1484–1488. [PubMed] [Google Scholar]
  100. Hoffman A. A., Harbeck R. J. Immunoregulation in New Zealand mice. I. Failure of the transfer of syngeneic spleen or thymus cells to influence the natural disease in New Zealand mice. Arthritis Rheum. 1979 Apr;22(4):412–418. doi: 10.1002/art.1780220416. [DOI] [PubMed] [Google Scholar]
  101. Honjo T., Nakai S., Nishida Y., Kataoka T., Yamawaki-Kataoka Y., Takahashi N., Obata M., Shimizu A., Yaoita Y., Nikaido T. Rearrangements of immunoglobulin genes during differentiation and evolution. Immunol Rev. 1981;59:33–67. doi: 10.1111/j.1600-065x.1981.tb00455.x. [DOI] [PubMed] [Google Scholar]
  102. Hurd E. R., Johnston J. M., Okita J. R., MacDonald P. C., Ziff M., Gilliam J. W. Prevention of glomerulonephritis and prolonged survival in New Zealand Black/New Zealand White F1 hybrid mice fed an essential fatty acid-deficient diet. J Clin Invest. 1981 Feb;67(2):476–485. doi: 10.1172/JCI110056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  103. Imamura M., Phillips P. E., Mellors R. C. The occurrence and frequency of type C virus-like particles in placentas from patients with systemic lupus erythematosus and from normal subjects. Am J Pathol. 1976 May;83(2):383–394. [PMC free article] [PubMed] [Google Scholar]
  104. Izui S., Eisenberg R. A., Dixon F. J. IgM rheumatoid factors in mice injected with bacterial lipopolysaccharides. J Immunol. 1979 May;122(5):2096–2102. [PubMed] [Google Scholar]
  105. Izui S., Eisenberg R. A., Dixon F. J. Subclass-restricted IgG polyclonal antibody production in mice injected with lipid A-rich lipopolysaccharides. J Exp Med. 1981 Feb 1;153(2):324–338. doi: 10.1084/jem.153.2.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Izui S., Elder J. H., McConahey P. J., Dixon F. J. Identification of retroviral gp70 and anti-gp70 antibodies involved in circulating immune complexes in NZB X NZW mice. J Exp Med. 1981 May 1;153(5):1151–1160. doi: 10.1084/jem.153.5.1151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  107. Izui S., Fernandes G., Hara I., McConahey P. J., Jensen F. C., Dixon F. J., Good R. A. Low-calorie diet selectively reduces expression of retroviral envelope glycoprotein gp70 in sera of NZB x NZW F1 hybrid mice. J Exp Med. 1981 Oct 1;154(4):1116–1124. doi: 10.1084/jem.154.4.1116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Izui S., Kelley V. E., McConahey P. J., Dixon F. J. Selective suppression of retroviral gp70-anti-gp70 immune complex formation by prostaglandin E1 in murine systemic lupus erythematosus. J Exp Med. 1980 Dec 1;152(6):1645–1658. doi: 10.1084/jem.152.6.1645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Izui S., Kobayakawa T., Louis J., Lambert P. H. Induction of thymocytotoxic autoantibodies after injection of bacterial lipopolysaccharides in mice. Eur J Immunol. 1979 Apr;9(4):338–341. doi: 10.1002/eji.1830090416. [DOI] [PubMed] [Google Scholar]
  110. Izui S., Lambert P. H., Fournié G. J., Türler H., Miescher P. A. Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: identificantion of circulating DNA and renal localization of DNA-anti-DNA complexes. J Exp Med. 1977 May 1;145(5):1115–1130. doi: 10.1084/jem.145.5.1115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Izui S., McConahey P. J., Clark J. P., Hang L. M., Hara I., Dixon F. J. Retroviral gp70 immune complexes in NZB x NZW F2 mice with murine lupus nephritis. J Exp Med. 1981 Aug 1;154(2):517–528. doi: 10.1084/jem.154.2.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Izui S., McConahey P. J., Dixon F. J. Increased spontaneous polyclonal activation of B lymphocytes in mice with spontaneous autoimmune disease. J Immunol. 1978 Dec;121(6):2213–2219. [PubMed] [Google Scholar]
  113. Izui S., McConahey P. J., Theofilopoulos A. N., Dixon F. J. Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus. J Exp Med. 1979 May 1;149(5):1099–1116. doi: 10.1084/jem.149.5.1099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  114. Janeway C. A., Jr, Sakato N., Eisen H. N. Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2357–2360. doi: 10.1073/pnas.72.6.2357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  115. Jerne N. K. THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION. Proc Natl Acad Sci U S A. 1955 Nov 15;41(11):849–857. doi: 10.1073/pnas.41.11.849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  116. Jerne N. K. The somatic generation of immune recognition. Eur J Immunol. 1971 Jan;1(1):1–9. doi: 10.1002/eji.1830010102. [DOI] [PubMed] [Google Scholar]
  117. Jerne N. K. Towards a network theory of the immune system. Ann Immunol (Paris) 1974 Jan;125C(1-2):373–389. [PubMed] [Google Scholar]
  118. Jyonouchi H., Kincade P. W., Good R. A., Fernandes G. Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice. J Immunol. 1981 Sep;127(3):1232–1235. [PubMed] [Google Scholar]
  119. Kahn C. R., Flier J. S., Bar R. S., Archer J. A., Gorden P., Martin M. M., Roth J. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med. 1976 Apr 1;294(14):739–745. doi: 10.1056/NEJM197604012941401. [DOI] [PubMed] [Google Scholar]
  120. Katz D. H., Benacerraf B. The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products. Transplant Rev. 1975;22:175–195. doi: 10.1111/j.1600-065x.1975.tb01559.x. [DOI] [PubMed] [Google Scholar]
  121. Kelley V. E., Winkelstein A., Izui S., Dixon F. J. Prostaglandin E1 inhibits T-cell proliferation and renal disease in MRL/1 mice. Clin Immunol Immunopathol. 1981 Nov;21(2):190–203. doi: 10.1016/0090-1229(81)90208-7. [DOI] [PubMed] [Google Scholar]
  122. Kemp J. D., Cowdery J. S., Steinberg A. D., Gershon R. K. Genetic control of autoimmune disease: interactions between xid and Ipr. J Immunol. 1982 Jan;128(1):388–392. [PubMed] [Google Scholar]
  123. Kidd A., Okita N., Row V. V., Volpé R. Immunologic aspects of Graves' and Hashimoto's diseases. Metabolism. 1980 Jan;29(1):80–99. doi: 10.1016/0026-0495(80)90102-x. [DOI] [PubMed] [Google Scholar]
  124. Klassen L. W., Krakauer R. S., Steinberg A. D. Selective loss of suppressor cell function in New Zealand mice induced by NTA. J Immunol. 1977 Sep;119(3):830–830. [PubMed] [Google Scholar]
  125. Kluskens L., Köhler H. Regulation of immune response by autogenous antibody against receptor. Proc Natl Acad Sci U S A. 1974 Dec;71(12):5083–5087. doi: 10.1073/pnas.71.12.5083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  126. Knight J. G., Adams D. D., Purves H. D. The genetic contribution of the NZB mouse to the renal disease of the NZB x NZW hybrid. Clin Exp Immunol. 1977 May;28(2):352–358. [PMC free article] [PubMed] [Google Scholar]
  127. Knight J. G., Adams D. D. Three genes for lupus nephritis in NZB x NZW mice. J Exp Med. 1978 Jun 1;147(6):1653–1660. doi: 10.1084/jem.147.6.1653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  128. Kobayakawa T., Louis J., Izui S., Lambert P. H. Autoimmune response to DNA, red blood cells, and thymocyte antigens in association with polyclonal antibody synthesis during experimental African trypanosomiasis. J Immunol. 1979 Jan;122(1):296–301. [PubMed] [Google Scholar]
  129. Kotzin B. L., Strober S., Engleman E. G., Calin A., Hoppe R. T., Kansas G. S., Terrell C. P., Kaplan H. S. Treatment of intractable rheumatoid arthritis with total lymphoid irradiation. N Engl J Med. 1981 Oct 22;305(17):969–976. doi: 10.1056/NEJM198110223051702. [DOI] [PubMed] [Google Scholar]
  130. Krakauer R. S., Strober W., Rippeon D. L., Waldmann T. A. Prevention of autoimmunity in experimental lupus erythematosus by soluble immune response suppressor. Science. 1977 Apr 1;196(4285):56–59. doi: 10.1126/science.300174. [DOI] [PubMed] [Google Scholar]
  131. Krakauer R. S., Waldmann T. A., Strober W. Loss of suppressor T cells in adult NZB/NZW mice. J Exp Med. 1976 Sep 1;144(3):662–673. doi: 10.1084/jem.144.3.662. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. Krawinkel U., Cramer M., Kindred B., Rajewsky K. Isolated hapten-binding receptors of sensitized lymphocytes. V. Cellular origin of receptor molecules. Eur J Immunol. 1979 Oct;9(10):815–820. doi: 10.1002/eji.1830091013. [DOI] [PubMed] [Google Scholar]
  133. Kunkel H. G., Agnello V., Joslin F. G., Winchester R. J., Capra J. D. Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med. 1973 Feb 1;137(2):331–342. doi: 10.1084/jem.137.2.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Kunkel H. G., Mannik M., Williams R. C. Individual Antigenic Specificity of Isolated Antibodies. Science. 1963 Jun 14;140(3572):1218–1219. doi: 10.1126/science.140.3572.1218. [DOI] [PubMed] [Google Scholar]
  135. Kunkel H. G. The immunopathology of SLE. Hosp Pract. 1980 Nov;15(11):47–56. doi: 10.1080/21548331.1980.11946682. [DOI] [PubMed] [Google Scholar]
  136. Kysela S., Steinberg A. D. Increased survival of NZB-W mice given multiple syngeneic young thymus grafts. Clin Immunol Immunopathol. 1973 Nov;2(1):133–136. doi: 10.1016/0090-1229(73)90043-3. [DOI] [PubMed] [Google Scholar]
  137. Lafer E. M., Möller A., Nordheim A., Stollar B. D., Rich A. Antibodies specific for left-handed Z-DNA. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3546–3550. doi: 10.1073/pnas.78.6.3546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  138. Lafer E. M., Rauch J., Andrzejewski C., Jr, Mudd D., Furie B., Furie B., Schwartz R. S., Stollar B. D. Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J Exp Med. 1981 Apr 1;153(4):897–909. doi: 10.1084/jem.153.4.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Lahita R. G., Bradlow H. L., Kunkel H. G., Fishman J. Alterations of estrogen metabolism in systemic lupus erythematosus. Arthritis Rheum. 1979 Nov;22(11):1195–1198. doi: 10.1002/art.1780221106. [DOI] [PubMed] [Google Scholar]
  140. Langman R. E. Cell-mediated immunity and the major histocompatibility complex. Rev Physiol Biochem Pharmacol. 1978;81:1–37. doi: 10.1007/BFb0034090. [DOI] [PubMed] [Google Scholar]
  141. Laskin C. A., Taurog J. D., Smathers P. A., Steinberg A. D. Studies of defective tolerance in murine lupus. J Immunol. 1981 Nov;127(5):1743–1747. [PubMed] [Google Scholar]
  142. Lawley T. J., Hall R. P., Fauci A. S., Katz S. I., Hamburger M. I., Frank M. M. Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. N Engl J Med. 1981 Jan 22;304(4):185–192. doi: 10.1056/NEJM198101223040401. [DOI] [PubMed] [Google Scholar]
  143. Ledbetter J. A., Rouse R. V., Micklem H. S., Herzenberg L. A. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J Exp Med. 1980 Aug 1;152(2):280–295. doi: 10.1084/jem.152.2.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  144. Lerner M. R., Steitz J. A. Snurps and scyrps. Cell. 1981 Aug;25(2):298–300. doi: 10.1016/0092-8674(81)90047-7. [DOI] [PubMed] [Google Scholar]
  145. Lerner R. A., Wilson C. B., Villano B. C., McConahey P. J., Dixon F. J. Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70. J Exp Med. 1976 Jan 1;143(1):151–166. doi: 10.1084/jem.143.1.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  146. Lewis D. E., Giorgi J. V., Warner N. L. Flow cytometry analysis of T cells and continuous T-cell lines from autoimmune MRL/l mice. Nature. 1981 Jan 22;289(5795):298–300. doi: 10.1038/289298a0. [DOI] [PubMed] [Google Scholar]
  147. Lewis R. M., Schwartz R. S. Canine systemic lupus erythematosus. Genetic analysis of an established breeding colony. J Exp Med. 1971 Aug 1;134(2):417–438. doi: 10.1084/jem.134.2.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  148. Lewis R. M., Tannenberg W., Smith C., Schwartz R. S. C-type viruses in systemic lupus erythematosus. Nature. 1974 Nov 1;252(5478):78–79. doi: 10.1038/252078a0. [DOI] [PubMed] [Google Scholar]
  149. Lindenmann J. Homobodies: do they exist? Ann Immunol (Paris) 1979 Mar-Apr;130(2):311–318. [PubMed] [Google Scholar]
  150. Lindstrom J. Autoimmune response to acetylcholine receptors in myasthenia gravis and its animal model. Adv Immunol. 1979;27:1–50. doi: 10.1016/s0065-2776(08)60261-8. [DOI] [PubMed] [Google Scholar]
  151. Lu C. Y., Beller D. I., Unanue E. R. During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1597–1601. doi: 10.1073/pnas.77.3.1597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  152. Lu C. Y., Calamai E. G., Unanue E. R. A defect in the antigen-presenting function of macrophages from neonatal mice. Nature. 1979 Nov 15;282(5736):327–329. doi: 10.1038/282327a0. [DOI] [PubMed] [Google Scholar]
  153. Magilavy D. B., Rifai A., Plotz P. H. An abnormality of immune complex kinetics in murine lupus. J Immunol. 1981 Feb;126(2):770–774. [PubMed] [Google Scholar]
  154. Manny N., Datta S. K., Schwartz R. S. Synthesis of IgM by cells of NZB and SWR mice and their crosses. J Immunol. 1979 Apr;122(4):1220–1227. [PubMed] [Google Scholar]
  155. Markenson J. A., Phillips P. E. Type C viruses and systemic lupus erythematosus. Arthritis Rheum. 1978 Mar;21(2):266–270. doi: 10.1002/art.1780210217. [DOI] [PubMed] [Google Scholar]
  156. Matzinger P. A one-receptor view of T-cell behaviour. Nature. 1981 Aug 6;292(5823):497–501. doi: 10.1038/292497a0. [DOI] [PubMed] [Google Scholar]
  157. Mehta J., Knotts L., Craig C., Burkholder S., Miller C., Hahn B. Effect of altered lymphocyte function on immunologic disorders in NZB/NZW mice. III. Acceleration of disease by thymosin. Arthritis Rheum. 1978 Mar;21(2):196–203. doi: 10.1002/art.1780210204. [DOI] [PubMed] [Google Scholar]
  158. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice. J Exp Med. 1967 Jul 1;126(1):53–62. doi: 10.1084/jem.126.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  159. Mellors R. C., Mellors J. W. Antigen related to mammalian type-C RNA viral p30 proteins is located in renal glomeruli in human systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1976 Jan;73(1):233–237. doi: 10.1073/pnas.73.1.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  160. Mellors R. C., Shirai T., Aoki T., Huebner R. J., Krawczynski K. Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice. J Exp Med. 1971 Jan 1;133(1):113–132. doi: 10.1084/jem.133.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  161. Mentnech M. S., Pearson D. J., Elliott J. A., Taylor G., Major P. C. Correlation of gm allotype with the incidience of anti-IgG antibody in coal workers' pneumoconiosis. Clin Immunol Immunopathol. 1980 Oct;17(2):274–279. doi: 10.1016/0090-1229(80)90096-3. [DOI] [PubMed] [Google Scholar]
  162. Meredith P. J., Kristie J. A., Walford R. L. Aging increases expression of LPS-induced autoantibody-secreting B cells. J Immunol. 1979 Jul;123(1):87–91. [PubMed] [Google Scholar]
  163. Metcalf E. S., Schrater A. F., Klinman N. R. Murine models of tolerance induction in developing and mature B cells. Immunol Rev. 1979;43:142–183. doi: 10.1111/j.1600-065x.1979.tb00421.x. [DOI] [PubMed] [Google Scholar]
  164. Michalski J. P., Snyder S. M., McLeod R. L., Talal N. Monozygotic twins with Klinefelter's syndrome discordant for systemic lupus erythematosus and symptomatic myasthenia gravis. Arthritis Rheum. 1978 Apr;21(3):306–309. doi: 10.1002/art.1780210303. [DOI] [PubMed] [Google Scholar]
  165. Miller K. B., Schwartz R. S. Familial abnormalities of suppressor-cell function in systemic lupus erythematosus. N Engl J Med. 1979 Oct 11;301(15):803–809. doi: 10.1056/NEJM197910113011502. [DOI] [PubMed] [Google Scholar]
  166. Moretta L., Ferrarini M., Cooper M. D. Characterization of human T-cell subpopulations as defined by specific receptors for immunoglobulins. Contemp Top Immunobiol. 1978;8:19–53. doi: 10.1007/978-1-4684-0922-2_2. [DOI] [PubMed] [Google Scholar]
  167. Morgan A. G., Steward M. W. Macrophage clearance function and immune complex disease in New Zealand Black/White F1 hybrid mice. Clin Exp Immunol. 1976 Oct;26(1):133–136. [PMC free article] [PubMed] [Google Scholar]
  168. Morton J. I., Siegel B. V. Reticuloendothelial activity of New Zealand black mice. Proc Soc Exp Biol Med. 1970 Mar;133(3):1055–1059. doi: 10.3181/00379727-133-34624. [DOI] [PubMed] [Google Scholar]
  169. Morton J. I., Siegel B. V. Transplantation of autoimmune potential. I. Development of antinuclear antibodies in H-2 histocompatible recipients of bone marrow from New Zealand Black mice. Proc Natl Acad Sci U S A. 1974 Jun;71(6):2162–2165. doi: 10.1073/pnas.71.6.2162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Morton J. I., Siegel B. V. Transplantation of autoimmune potential. IV. Reversal of the NZB autoimmune syndrome by bone marrow transplantation. Transplantation. 1979 Feb;27(2):133–134. [PubMed] [Google Scholar]
  171. Moutsopoulos H. M., Boehm-Truitt M., Kassan S. S., Chused T. M. Demonstration of activation of B lymphocytes in New Zealand black mice at birth by an immunoradiometric assay for murine IgM. J Immunol. 1977 Nov;119(5):1639–1644. [PubMed] [Google Scholar]
  172. Murphy E. D., Roths J. B. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188–1194. doi: 10.1002/art.1780221105. [DOI] [PubMed] [Google Scholar]
  173. Mäkelä O., Karjalainen K. Inherited immunoglobulin idiotypes of the mouse. Immunol Rev. 1977;34:119–138. doi: 10.1111/j.1600-065x.1977.tb00370.x. [DOI] [PubMed] [Google Scholar]
  174. Nakamura Z., Asano T., Yano K., Ofuji T. Reevaluation of suppressor cell function in systemic lupus erythematosus. Clin Immunol Immunopathol. 1982 Jul;24(1):72–82. doi: 10.1016/0090-1229(82)90090-3. [DOI] [PubMed] [Google Scholar]
  175. Nakao Y., Matsumoto H., Miyazaki T., Mizuno N., Arima N., Wakisaka A., Okimoto K., Akazawa Y., Tsuji K., Fujita T. IgG heavy-chain (Gm) allotypes and immune response to insulin in insulin-requiring diabetes mellitus. N Engl J Med. 1981 Feb 12;304(7):407–409. doi: 10.1056/NEJM198102123040706. [DOI] [PubMed] [Google Scholar]
  176. Nakao Y., Matsumoto H., Miyazaki T., Nishitani H., Ota K., Fujita T., Tsuji K. Gm allotypes in myasthenia gravis. Lancet. 1980 Mar 29;1(8170):677–680. [PubMed] [Google Scholar]
  177. Nakao Y., Matsumoto H., Miyazaki T., Nishitani H., Takatsuki K., Kasukawa R., Nakayama S., Izumi S., Fujita T., Tsuji K. IgG heavy chain allotypes (Gm) in autoimmune diseases. Clin Exp Immunol. 1980 Oct;42(1):20–26. [PMC free article] [PubMed] [Google Scholar]
  178. Neilson E. G., Phillips M. Suppression of interstitial nephritis by auto-anti-idiotypic immunity. J Exp Med. 1982 Jan 1;155(1):179–189. doi: 10.1084/jem.155.1.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  179. Nisonoff A., Lamoyi E. Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: possible application to vaccine production. Clin Immunol Immunopathol. 1981 Dec;21(3):397–406. doi: 10.1016/0090-1229(81)90228-2. [DOI] [PubMed] [Google Scholar]
  180. Nossal G. J., Pike B. L. Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3844–3847. doi: 10.1073/pnas.78.6.3844. [DOI] [PMC free article] [PubMed] [Google Scholar]
  181. Ortiz-Ortiz L., Parks D. E., Rodriguez M., Weigle W. O. Polyclonal B lymphocyte activation during Trypanosoma cruzi infection. J Immunol. 1980 Jan;124(1):121–126. [PubMed] [Google Scholar]
  182. Oudin J., Michel M. Idiotypy of rabbit antibodies. I. Comparison of idiotypy of antibodies against Salmonella typhi with that of antibodies against other bacteria in the same rabbits, or of antibodies against Salmonella typhi in various rabbits. J Exp Med. 1969 Sep 1;130(3):595–617. doi: 10.1084/jem.130.3.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  183. Owen R. D. IMMUNOGENETIC CONSEQUENCES OF VASCULAR ANASTOMOSES BETWEEN BOVINE TWINS. Science. 1945 Oct 19;102(2651):400–401. doi: 10.1126/science.102.2651.400. [DOI] [PubMed] [Google Scholar]
  184. Panem S., Ordóez N. G., Kirstein W. H., Katz A. I., Spargo B. H. C-type virus expression in systemic lupus erythematosus. N Engl J Med. 1976 Aug 26;295(9):470–475. doi: 10.1056/NEJM197608262950903. [DOI] [PubMed] [Google Scholar]
  185. Pasquali J. L., Fong S., Tsoukas C., Vaughan J. H., Carson D. A. Inheritance of immunoglobulin M rheumatoid-factor idiotypes. J Clin Invest. 1980 Oct;66(4):863–866. doi: 10.1172/JCI109927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  186. Pawlak L. L., Mushinski E. B., Nisonoff A., Potter M. Evidence for the linkage of the IGC H locus to a gene controlling the idiotypic specificity of anti-p-azophenylarsonate antibodies in strain A mice. J Exp Med. 1973 Jan 1;137(1):22–31. doi: 10.1084/jem.137.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  187. Phillips P. E., Hargrave-Granda R. Type C oncornavirus isolation studies in systemic lupus erythematosus. II. Attempted detection by viral RNA-dependent DNA polymerase assay. Ann Rheum Dis. 1978 Jun;37(3):225–233. doi: 10.1136/ard.37.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  188. Phillips P. E. The virus hypothesis in systemic lupus erythematosus. Ann Intern Med. 1975 Nov;83(5):709–715. doi: 10.7326/0003-4819-83-5-709. [DOI] [PubMed] [Google Scholar]
  189. Pincus T., Steinberg A. D., Blacklow N. R., Decker J. L. Reactivities of systemic lupus erythematosus sera with cellular and virus antigen preparations. Arthritis Rheum. 1978 Nov-Dec;21(8):873–879. doi: 10.1002/art.1780210801. [DOI] [PubMed] [Google Scholar]
  190. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. I. In vivo viral replication and the host antibody response to viral antigen. J Exp Med. 1969 Sep 1;130(3):575–593. doi: 10.1084/jem.130.3.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  191. Primi D., Hammarström L., Smith C. I., Möller G. Immunological unresponsiveness of self-recognizing B lymphocytes to the PBA property of a soluble T cell factor. Cell Immunol. 1978 Dec;41(2):320–329. doi: 10.1016/0008-8749(78)90229-0. [DOI] [PubMed] [Google Scholar]
  192. Puré E., Isakson P. C., Takatsu K., Hamaoka T., Swain S. L., Dutton R. W., Dennert G., Uhr J. W., Vitetta E. S. Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line. J Immunol. 1981 Nov;127(5):1953–1958. [PubMed] [Google Scholar]
  193. Quimby F. W., Schwartz R. S. The etiopathogenesis of systemic lupus erythematosus. Pathobiol Annu. 1978;8:35–59. [PubMed] [Google Scholar]
  194. ROSENBERG L. T., TACHIBANA D. K. Activity of mouse complement. J Immunol. 1962 Dec;89:861–867. [PubMed] [Google Scholar]
  195. Raff M. C., Owen J. J., Cooper M. D., Lawton A. R., 3rd, Megson M., Gathings W. E. Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self. J Exp Med. 1975 Nov 1;142(5):1052–1064. doi: 10.1084/jem.142.5.1052. [DOI] [PMC free article] [PubMed] [Google Scholar]
  196. Raveche E. S., Novotny E. A., Hansen C. T., Tjio J. H., Steinberg A. D. Genetic studies in NZB mice. V. Recombinant inbred lines demonstrate that separate genes control autoimmune phenotype. J Exp Med. 1981 May 1;153(5):1187–1197. doi: 10.1084/jem.153.5.1187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  197. Raveche E. S., Steinberg A. D. Lymphocytes and lymphocyte functions in systemic lupus erythematosus. Semin Hematol. 1979 Oct;16(4):344–370. [PubMed] [Google Scholar]
  198. Raveché E. S., Steinberg A. D., Klassen L. W., Tjio J. H. Genetic studies in NZB mice. I. Spontaneous autoantibody production. J Exp Med. 1978 May 1;147(5):1487–1502. doi: 10.1084/jem.147.5.1487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  199. Reinherz E. L., Kung P. C., Goldstein G., Schlossman S. F. A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol. 1980 Mar;124(3):1301–1307. [PubMed] [Google Scholar]
  200. Reinherz E. L., Kung P. C., Goldstein G., Schlossman S. F. Further characterization of the human inducer T cell subset defined by monoclonal antibody. J Immunol. 1979 Dec;123(6):2894–2896. [PubMed] [Google Scholar]
  201. Rosenthal A. S. Determinant selection and macrophage function in genetic control of the immune response. Immunol Rev. 1978;40:136–152. doi: 10.1111/j.1600-065x.1978.tb00404.x. [DOI] [PubMed] [Google Scholar]
  202. Rosenthal A. S. Regulation of the immune response--role of the macrophage. N Engl J Med. 1980 Nov 13;303(20):1153–1156. doi: 10.1056/NEJM198011133032005. [DOI] [PubMed] [Google Scholar]
  203. Rosén A., Gergely P., Jondal M., Klein G., Britton S. Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro. Nature. 1977 May 5;267(5606):52–54. doi: 10.1038/267052a0. [DOI] [PubMed] [Google Scholar]
  204. Roth J. Insulin receptors in diabetes. Hosp Pract. 1980 May;15(5):98–103. doi: 10.1080/21548331.1980.11946601. [DOI] [PubMed] [Google Scholar]
  205. Roubinian J. R., Papoian R., Talal N. Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest. 1977 Jun;59(6):1066–1070. doi: 10.1172/JCI108729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  206. Roubinian J. R., Papoian R., Talal N. Effects of neonatal thymectomy and splenectomy on survival and regulation of autoantibody formation in NZB/NZW F1 mice. J Immunol. 1977 May;118(5):1524–1529. [PubMed] [Google Scholar]
  207. Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. doi: 10.1084/jem.147.6.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  208. Roubinian J., Talal N., Siiteri P. K., Sadakian J. A. Sex hormone modulation of autoimmunity in NZB/NZW mice. Arthritis Rheum. 1979 Nov;22(11):1162–1169. doi: 10.1002/art.1780221102. [DOI] [PubMed] [Google Scholar]
  209. Russell P. J., Hicks J. D., Boston L. E., Abbott A. Failure to transfer haemolytic anaemia or glomerulonephritis with cell-free material from NZB mice. Clin Exp Immunol. 1970 Feb;6(2):227–239. [PMC free article] [PubMed] [Google Scholar]
  210. Sacks D. L., Esser K. M., Sher A. Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies. J Exp Med. 1982 Apr 1;155(4):1108–1119. doi: 10.1084/jem.155.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  211. Sagawa A., Abdou N. I. Suppressor-cell dysfunction in systemic lupus erythematosus. Cells involved and in vitro correction. J Clin Invest. 1978 Oct;62(4):789–796. doi: 10.1172/JCI109190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  212. Sakane T., Steinberg A. D., Green I. Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3464–3468. doi: 10.1073/pnas.75.7.3464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  213. Sakane T., Steinberg A. D., Reeves J. P., Green I. Studies of immune functions of patients with systemic lupus erythematosus. Complement-dependent immunoglobulin M anti-thymus-derived cell antibodies preferentially inactivate suppressor cells. J Clin Invest. 1979 May;63(5):954–965. doi: 10.1172/JCI109396. [DOI] [PMC free article] [PubMed] [Google Scholar]
  214. Sakane T., Steinberg A. D., Reeves J. P., Green I. Studies of immune functions of patients with systemic lupus erythematosus. T-cell subsets and antibodies to T-cell subsets. J Clin Invest. 1979 Nov;64(5):1260–1269. doi: 10.1172/JCI109581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  215. Sandberg H. O., Closs O. The humoral immune response to alpha, beta and gamma crystallins of the human lens. Scand J Immunol. 1979;10(6):549–554. doi: 10.1111/j.1365-3083.1979.tb01389.x. [DOI] [PubMed] [Google Scholar]
  216. Santoro T. J., Scott D. W., Pisetsky D. S. The induction of tolerance and suppression in autoimmune MRL mice using hapten-modified self. J Immunol. 1981 Aug;127(2):690–693. [PubMed] [Google Scholar]
  217. Schaap O. L., De Groot E. R., Van Loghem J. J. Failure to induce autoimmune phenomena in mice by administration of highly purified C-type particles from NZB mice. Pathol Microbiol (Basel) 1975;42(3):171–187. doi: 10.1159/000162737. [DOI] [PubMed] [Google Scholar]
  218. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. doi: 10.1056/NEJM197304052881403. [DOI] [PubMed] [Google Scholar]
  219. Schreiber A. B., Couraud P. O., Andre C., Vray B., Strosberg A. D. Anti-alprenolol anti-idiotypic antibodies bind to beta-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7385–7389. doi: 10.1073/pnas.77.12.7385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  220. Schwartz M., Lifshitz R., Givol D., Mozes E., Haimovich J. Cross-reactive idiotypic determinants on murine anti-(T,G)-A--L antibodies. J Immunol. 1978 Aug;121(2):421–426. [PubMed] [Google Scholar]
  221. Schwartz R. S. Virsues and systemic lupus erythematosus. N Engl J Med. 1975 Jul 17;293(3):132–136. doi: 10.1056/NEJM197507172930308. [DOI] [PubMed] [Google Scholar]
  222. Sege K., Peterson P. A. Use of anti-idiotypic antibodies as cell-surface receptor probes. Proc Natl Acad Sci U S A. 1978 May;75(5):2443–2447. doi: 10.1073/pnas.75.5.2443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  223. Sercarz E. E., Yowell R. L., Turkin D., Miller A., Araneo B. A., Adorini L. Different functional specificity repertoires for suppressor and helper T cells. Immunol Rev. 1978;39:108–136. doi: 10.1111/j.1600-065x.1978.tb00398.x. [DOI] [PubMed] [Google Scholar]
  224. Shander M., Martinis J., Croce C. M. Genetics of human immunoglobulins: assignment of the genes for mu, alpha, and gamma immunoglobulin chains to human chromosome 14. Transplant Proc. 1980 Sep;12(3):417–420. [PubMed] [Google Scholar]
  225. Shearer G. M., Schmitt-Verhulst A. M. Major histocompatibility complex restricted cell-mediated immunity. Adv Immunol. 1977;25:55–91. doi: 10.1016/s0065-2776(08)60931-1. [DOI] [PubMed] [Google Scholar]
  226. Shechter Y., Maron R., Elias D., Cohen I. R. Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin. Science. 1982 Apr 30;216(4545):542–545. doi: 10.1126/science.7041258. [DOI] [PubMed] [Google Scholar]
  227. Shirai T., Hayakawa K., Okumura K., Tada T. Differential cytotoxic effect of natural thymocytotoxic autoantibody of NZB mice on functional subsets of T cells. J Immunol. 1978 Jun;120(6):1924–1929. [PubMed] [Google Scholar]
  228. Shulman H. M., Sullivan K. M., Weiden P. L., McDonald G. B., Striker G. E., Sale G. E., Hackman R., Tsoi M. S., Storb R., Thomas E. D. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med. 1980 Aug;69(2):204–217. doi: 10.1016/0002-9343(80)90380-0. [DOI] [PubMed] [Google Scholar]
  229. Sidman C. L., Unanue E. R. Receptor-mediated inactivation of early B lymphocytes. Nature. 1975 Sep 11;257(5522):149–151. doi: 10.1038/257149a0. [DOI] [PubMed] [Google Scholar]
  230. Slaughter L., Carson D. A., Jensen F. C., Holbrook T. L., Vaughan J. H. In vitro effects of Epstein-Barr virus on peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal subjects. J Exp Med. 1978 Nov 1;148(5):1429–1434. doi: 10.1084/jem.148.5.1429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  231. Snyder H. W., Jr, Fleissner E. Specificity of human antibodies to oncovirus glycoproteins: recognition of antigen by natural antibodies directed against carbohydrate structures. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1622–1626. doi: 10.1073/pnas.77.3.1622. [DOI] [PMC free article] [PubMed] [Google Scholar]
  232. Staples P. J., Talal N. Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice. J Exp Med. 1969 Jan 1;129(1):123–139. doi: 10.1084/jem.129.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  233. Stastny P., Ziff M. Antibodies against cell membrane constituents in systemic lupus erythematosus and related diseases. I. Cytotoxic effect of serum from patients with systemic lupus erythematosus (SLE) for allogeneic and for autologous lymphocytes. Clin Exp Immunol. 1971 Apr;8(4):543–550. [PMC free article] [PubMed] [Google Scholar]
  234. Steinberg A. D., Krakauer R., Reinertsen J. L., Klassen L. W., Ilfeld D., Reeves J. P., Williams G. W., Antonovych T. Therapeutic studies in NZB/NZW mice. VI. Age-dependent effects of concanavalin A stimulated spleen cell supernate. Arthritis Rheum. 1978 Mar;21(2):204–209. doi: 10.1002/art.1780210205. [DOI] [PubMed] [Google Scholar]
  235. Steinberg A. D., Law L. D., Talal N. The role of NZB-NZW F1 thymus in experimental tolerance and auto-immunity. Arthritis Rheum. 1970 Jul-Aug;13(4):369–377. doi: 10.1002/art.1780130402. [DOI] [PubMed] [Google Scholar]
  236. Steinberg A. D., Melez K. A., Raveche E. S., Reeves J. P., Boegel W. A., Smathers P. A., Taurog J. D., Weinlein L., Duvic M. Approach to the study of the role of sex hormones in autoimmunity. Arthritis Rheum. 1979 Nov;22(11):1170–1176. doi: 10.1002/art.1780221103. [DOI] [PubMed] [Google Scholar]
  237. Steinberg A. D., Roths J. B., Murphy E. D., Steinberg R. T., Raveche E. S. Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice. J Immunol. 1980 Aug;125(2):871–873. [PubMed] [Google Scholar]
  238. Stern R., Fishman J., Brusman H., Kunkel H. G. Systemic lupus erythematosus associated with klinefelter's syndrome. Arthritis Rheum. 1977 Jan-Feb;20(1):18–22. doi: 10.1002/art.1780200103. [DOI] [PubMed] [Google Scholar]
  239. Strand M., August J. T. Type-C RNA virus gene expression in human tissue. J Virol. 1974 Dec;14(6):1584–1596. doi: 10.1128/jvi.14.6.1584-1596.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  240. Sunday M. E., Benacerraf B., Dorf M. E. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses. J Exp Med. 1981 Apr 1;153(4):811–822. doi: 10.1084/jem.153.4.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  241. Swan D., D'Eustachio P., Leinwand L., Seidman J., Keithley D., Ruddle F. H. Chromosomal assignment of the mouse kappa light chain genes. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2735–2739. doi: 10.1073/pnas.76.6.2735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  242. TRIPLETT E. L. On the mechanism of immunologic self recognition. J Immunol. 1962 Oct;89:505–510. [PubMed] [Google Scholar]
  243. Talal N., Dauphinee M., Pillarisetty R., Goldblum R. Effect of thymosin on thymocyte proliferation and autoimmunity in NZB mice. Ann N Y Acad Sci. 1975 Feb 28;249:438–450. doi: 10.1111/j.1749-6632.1975.tb29092.x. [DOI] [PubMed] [Google Scholar]
  244. Taurog J. D., Moutsopoulos H. M., Rosenberg Y. J., Chused T. M., Steinberg A. D. CBA/N X-linked B-cell defect prevents NZB B-cell hyperactivity in F1 mice. J Exp Med. 1979 Jul 1;150(1):31–43. doi: 10.1084/jem.150.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  245. Teale J. M., Klinman N. R. Tolerance as an active process. Nature. 1980 Nov 27;288(5789):385–387. doi: 10.1038/288385a0. [DOI] [PubMed] [Google Scholar]
  246. Teale J. M., Layton J. E., Nossal G. J. In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen. J Exp Med. 1979 Aug 1;150(2):205–217. doi: 10.1084/jem.150.2.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  247. Theofilopoulos A. N., Balderas R. S., Shawler D. L., Lee S., Dixon F. J. Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice. J Exp Med. 1981 Jun 1;153(6):1405–1414. doi: 10.1084/jem.153.6.1405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  248. Theofilopoulos A. N., Balderas R., Shawler D. L., Izui S., Kotzin B. L., Strober S., Dixon F. J. Inhibition of T cells proliferation and SLE-like syndrome of MRL/1 mice by whole body or total lymphoid irradiation. J Immunol. 1980 Nov;125(5):2137–2142. [PubMed] [Google Scholar]
  249. Theofilopoulos A. N., Dixon F. J. Etiopathogenesis of murine SLE. Immunol Rev. 1981;55:179–216. doi: 10.1111/j.1600-065x.1981.tb00343.x. [DOI] [PubMed] [Google Scholar]
  250. Theofilopoulos A. N., Dixon F. J. The biology and detection of immune complexes. Adv Immunol. 1979;28:89–220. doi: 10.1016/s0065-2776(08)60800-7. [DOI] [PubMed] [Google Scholar]
  251. Theofilopoulos A. N., Eisenberg R. A., Bourdon M., Crowell J. S., Jr, Dixon F. J. Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes. J Exp Med. 1979 Feb 1;149(2):516–534. doi: 10.1084/jem.149.2.516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  252. Theofilopoulos A. N., McConahey P. J., Izui S., Eisenberg R. A., Pereira A. B., Creighton W. D. A comparative immunologic analysis of several murine strains with autoimmune manifestations. Clin Immunol Immunopathol. 1980 Mar;15(3):258–278. doi: 10.1016/0090-1229(80)90039-2. [DOI] [PubMed] [Google Scholar]
  253. Theofilopoulos A. N., Shawler D. L., Eisenberg R. A., Dixon F. J. Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice. J Exp Med. 1980 Feb 1;151(2):446–466. doi: 10.1084/jem.151.2.446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  254. Thomas H. I., Weir D. M. The in vitro activity of peritoneal exudate cells from New Zealand black mice (NZB/B1) in the presence of I-125-BSA (bovine serum albumin). Clin Exp Immunol. 1972 Oct;12(2):263–272. [PMC free article] [PubMed] [Google Scholar]
  255. Thorley-Lawson D. A., Chess L., Strominger J. L. Suppression of in vitro Epstein-Barr virus infection. A new role for adult human T lymphocytes. J Exp Med. 1977 Aug 1;146(2):495–508. doi: 10.1084/jem.146.2.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  256. Tonietti G., Oldstone M. B., Dixon F. J. The effect of induced chronic viral infections on the immunologic diseases of New Zealand mice. J Exp Med. 1970 Jul 1;132(1):89–109. doi: 10.1084/jem.132.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  257. Tosato G., Steinberg A. D., Blaese R. M. Defective EBV-specific suppressor T-cell function in rheumatoid arthritis. N Engl J Med. 1981 Nov 19;305(21):1238–1243. doi: 10.1056/NEJM198111193052102. [DOI] [PubMed] [Google Scholar]
  258. Trentham D. E., Belli J. A., Anderson R. J., Buckley J. A., Goetzl E. J., David J. R., Austen K. F. Clinical and immunologic effects of fractionated total lymphoid irradiation in refractory rheumatoid arthritis. N Engl J Med. 1981 Oct 22;305(17):976–982. doi: 10.1056/NEJM198110223051703. [DOI] [PubMed] [Google Scholar]
  259. Unanue E. R. Cooperation between mononuclear phagocytes and lymphocytes in immunity. N Engl J Med. 1980 Oct 23;303(17):977–985. doi: 10.1056/NEJM198010233031706. [DOI] [PubMed] [Google Scholar]
  260. Uno H., Sasazuki T., Tamai H., Matsumoto H. Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease. Nature. 1981 Aug 20;292(5825):768–770. doi: 10.1038/292768a0. [DOI] [PubMed] [Google Scholar]
  261. Van Snick J. L. A gene linked to the Igh-C locus controls the production of rheumatoid factor in the mouse. J Exp Med. 1981 Mar 1;153(3):738–742. doi: 10.1084/jem.153.3.738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  262. Venables P. J., Roffe L. M., Erhardt C. C., Maini R. N., Edwards J. M., Porter A. D. Titers of antibodies to RANA in rheumatoid arthritis and normal sera. Relationship to Epstein-Barr virus infection. Arthritis Rheum. 1981 Dec;24(12):1459–1468. doi: 10.1002/art.1780241201. [DOI] [PubMed] [Google Scholar]
  263. Venter J. C., Fraser C. M., Harrison L. C. Autoantibodies to beta 2-adrenergic receptors: a possible cause of adrenergic hyporesponsiveness in allergic rhinitis and asthma. Science. 1980 Mar 21;207(4437):1361–1363. doi: 10.1126/science.6153472. [DOI] [PubMed] [Google Scholar]
  264. Vincent A. Idiotype restriction in myasthenia gravis antibodies. Nature. 1981 Mar 26;290(5804):293–294. doi: 10.1038/290293a0. [DOI] [PubMed] [Google Scholar]
  265. WEIGLE W. O. The immune response of rabbits tolerant to bovine serum albumin to the injection of other heterologous serum albumins. J Exp Med. 1961 Jul 1;114:111–125. doi: 10.1084/jem.114.1.111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  266. Watson J., Mochizuki D. Interleukin 2: a class of T cell growth factors. Immunol Rev. 1980;51:257–278. doi: 10.1111/j.1600-065x.1980.tb00324.x. [DOI] [PubMed] [Google Scholar]
  267. Weigle W. O. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv Immunol. 1980;30:159–273. doi: 10.1016/s0065-2776(08)60196-0. [DOI] [PubMed] [Google Scholar]
  268. Weigle W. O., High G. J., Nakamura R. M. The role of mycobacteria and the effect of proteolytic degradation of thyroglobulin on the production of autoimmune thyroiditis. J Exp Med. 1969 Aug 1;130(2):243–262. doi: 10.1084/jem.130.2.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  269. Weigle W. O. Recent observations and concepts in immunological unresponsiveness and autoimmunity. Clin Exp Immunol. 1971 Oct;9(4):437–447. [PMC free article] [PubMed] [Google Scholar]
  270. Weinstein Y., Berkovich Z. Testosterone effect on bone marrow, thymus, and suppressor T cells in the (NZB X NZW)F1 mice: its relevance to autoimmunity. J Immunol. 1981 Mar;126(3):998–1002. [PubMed] [Google Scholar]
  271. Wekerle H., Ketelsen U. P. Thymic nurse cells--Ia-bearing epithelium involved in T-lymphocyte differentiation? Nature. 1980 Jan 24;283(5745):402–404. doi: 10.1038/283402a0. [DOI] [PubMed] [Google Scholar]
  272. Weksler M. E. The senescence of the immune system. Hosp Pract (Off Ed) 1981 Oct;16(10):53–64. doi: 10.1080/21548331.1981.11946847. [DOI] [PubMed] [Google Scholar]
  273. Williamson A. R. Three-receptor, clonal expansion model for selection of self-recognition in the thymus. Nature. 1980 Feb 7;283(5747):527–532. doi: 10.1038/283527a0. [DOI] [PubMed] [Google Scholar]
  274. Winchester R. J., Kunkel H. G. The human Ia system. Adv Immunol. 1979;28:221–292. [PubMed] [Google Scholar]
  275. Winchester R. J., Winfield J. B., Siegal F., Wernet P., Bentwich Z., Kunkel H. G. Analyses of lymphocytes from patients with rheumatoid arthritis and systemic lupus erythematosus. Occurrence of interfering cold-reactive antilymphocyte antibodies. J Clin Invest. 1974 Nov;54(5):1082–1092. doi: 10.1172/JCI107852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  276. Winfield J. B., Winchester R. J., Wernet P., Fu S. M., Kunkel H. G. Nature of cold-reactive antibodies to lymphocyte surface determinants in systemic lupus erythematosus. Arthritis Rheum. 1975 Jan-Feb;18(1):1–8. doi: 10.1002/art.1780180101. [DOI] [PubMed] [Google Scholar]
  277. Worlledge S. M., Carstairs K. C., Dacie J. V. Autoimmune haemolytic anaemia associated with alpha-methyldopa therapy. Lancet. 1966 Jul 16;2(7455):135–139. doi: 10.1016/s0140-6736(66)92423-8. [DOI] [PubMed] [Google Scholar]
  278. Yang V. W., Lerner M. R., Steitz J. A., Flint S. J. A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences. Proc Natl Acad Sci U S A. 1981 Mar;78(3):1371–1375. doi: 10.1073/pnas.78.3.1371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  279. Yocum M. W., Grossman J., Waterhouse C., Abraham G. N., May A. G., Condemi J. J. Monozygotic twins discordant for systemic lupus erythematosus. Arthritis Rheum. 1975 May-Jun;18(3):193–199. doi: 10.1002/art.1780180301. [DOI] [PubMed] [Google Scholar]
  280. Yoshiki T., Mellors R. C., Strand M., August J. T. The viral envelope glycoprotein of murine leukemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice. J Exp Med. 1974 Oct 1;140(4):1011–1027. doi: 10.1084/jem.140.4.1011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  281. Zanetti M., Bigazzi P. E. Anti-idiotypic immunity and autoimmunity. I. In vitro and in vivo effects of anti-idiotypic antibodies to spontaneously occurring autoantibodies to rat thyroglobulin. Eur J Immunol. 1981 Mar;11(3):187–195. doi: 10.1002/eji.1830110306. [DOI] [PubMed] [Google Scholar]
  282. Zinkernagel R. M., Callahan G. N., Klein J., Dennert G. Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Nature. 1978 Jan 19;271(5642):251–253. doi: 10.1038/271251a0. [DOI] [PubMed] [Google Scholar]
  283. Zinkernagel R. M., Doherty P. C. MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol. 1979;27:51–177. doi: 10.1016/s0065-2776(08)60262-x. [DOI] [PubMed] [Google Scholar]
  284. de Freitas A. A., Coutinho A. Very rapid decay of mature B lymphocytes in the spleen. J Exp Med. 1981 Sep 1;154(3):994–999. doi: 10.1084/jem.154.3.994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  285. van Elven E. H., Agterberg J., Sadal S., Gleichmann E. Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex. II. Autoantibodies deposited along the basement membrane of skin and their relationship to immune-complex glomerulonephritis. J Immunol. 1981 May;126(5):1684–1691. [PubMed] [Google Scholar]
  286. van Elven E. H., van der Veen F. M., Rolink A. G., Issa P., Duin T. M., Gleichmann E. Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex. V. High titers of IgG autoantibodies to double-stranded DNA. J Immunol. 1981 Dec;127(6):2435–2438. [PubMed] [Google Scholar]
  287. van der Veen J. P., Rolink A. G., Gleichmann E. Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex. III. Autoantibodies to thymocytes. J Immunol. 1981 Oct;127(4):1281–1286. [PubMed] [Google Scholar]
  288. von Boehmer H., Haas W., Jerne N. K. Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice. Proc Natl Acad Sci U S A. 1978 May;75(5):2439–2442. doi: 10.1073/pnas.75.5.2439. [DOI] [PMC free article] [PubMed] [Google Scholar]

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