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. 1982 Oct;109(1):8–14.

Acute hemorrhagic pancreatic necrosis in mice. Induction in male mice treated with estradiol.

K N Rao, P K Eagon, K Okamura, D H Van Thiel, J S Gavaler, R H Kelly, B Lombardi
PMCID: PMC1916068  PMID: 6181693

Abstract

Acute hemorrhagic pancreatic necrosis (AHPN) is induced in young female mice fed fo 4 days a choline-deficient diet containing diet 0.5% DL-ethionine (CDE). Contrary to females, male mice do not develop AHPN when fed the same diet. For determination of whether estrogens are involved in the induction of AHPN, estradiol-treated male mice were fed the CDE diet. In such estrogen-treated male mice, the mortality rate, incidence of AHPN, and alterations in biochemical parameters of the pancreas and of serum were similar to those induced by the CDE diet in females.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adlercreutz H., Martin F. Biliary excretion and intestinal metabolism of progesterone and estrogens in man. J Steroid Biochem. 1980 Feb;13(2):231–244. doi: 10.1016/0022-4731(80)90196-x. [DOI] [PubMed] [Google Scholar]
  2. CLAUSEN J., HEREMANS J. An immunologic and chemical study of the similarities between mouse and human serum proteins. J Immunol. 1960 Feb;84:128–134. [PubMed] [Google Scholar]
  3. Davidoff F., Tishler S., Rosoff C. Marked hyperlipidemia and pancreatitis associated with oral contraceptive therapy. N Engl J Med. 1973 Sep 13;289(11):552–555. doi: 10.1056/NEJM197309132891103. [DOI] [PubMed] [Google Scholar]
  4. Eagon P. K., Zdunek J. R., van Thiel D. H., Singletary B. K., Egler K. M., Gavaler J. S., Porter L. E. Alcohol-induced changes in hepatic estrogen-binding proteins: a mechanism explaining feminization in alcoholics. Arch Biochem Biophys. 1981 Oct 1;211(1):48–54. doi: 10.1016/0003-9861(81)90428-8. [DOI] [PubMed] [Google Scholar]
  5. FARBER E., KOCH-WESER D., POPPER H. The influence of sex and of testosterone upon fatty liver due to ethionine. Endocrinology. 1951 Feb;48(2):205–212. doi: 10.1210/endo-48-2-205. [DOI] [PubMed] [Google Scholar]
  6. FARBER E., SEGALOFF A. Effect of androgens and growth and other hormones on ethionine fatty liver in rats. J Biol Chem. 1955 Oct;216(2):471–477. [PubMed] [Google Scholar]
  7. Foster M. E., Powell D. E. Pancreatitis, multiple infarcts and oral contraception. Postgrad Med J. 1975 Sep;51(599):667–669. doi: 10.1136/pgmj.51.599.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gay V. L., Hauger R. L. A sex-related pattern of gonadotropin secretion in the castrated rat: effects of changing the inhibitory steroid or pituitary LH content. Biol Reprod. 1977 May;16(4):527–535. [PubMed] [Google Scholar]
  9. Glueck C. J., Scheel D., Fishback J., Steiner P. Estrogen-induced pancreatitis in patients with previously covert familial type V hyperlipoproteinemia. Metabolism. 1972 Jul;21(7):657–666. doi: 10.1016/0026-0495(72)90089-3. [DOI] [PubMed] [Google Scholar]
  10. Hotchkiss J., Atkinson L. E., Knobil E. Time course of serum estrogen and luteinizing hormone (LH) concentrations during the menstrual cycle of the rhesus monkey. Endocrinology. 1971 Jul;89(1):177–183. doi: 10.1210/endo-89-1-177. [DOI] [PubMed] [Google Scholar]
  11. Jeppsson J. O., Laurell C. B., Franzén B. Agarose gel electrophoresis. Clin Chem. 1979 Apr;25(4):629–638. [PubMed] [Google Scholar]
  12. Kelly R. H., Rao K. N., Harvey V. S., Lombardi B. Acute hemorrhagic pancreatic necrosis in mice: alterations of serum complement. Digestion. 1981;22(1):1–7. doi: 10.1159/000198588. [DOI] [PubMed] [Google Scholar]
  13. Kelly R. H., Scholl M. A., Harvey V. S., Devenyi A. G. Qualitative testing for circulating immune complexes by use of zone electrophoresis on agarose. Clin Chem. 1980 Mar;26(3):396–402. [PubMed] [Google Scholar]
  14. Kirdani R. Y., Sandberg A. A., Murphy G. P. Estrogen-binding to pancreas. Surgery. 1973 Jul;74(1):84–90. [PubMed] [Google Scholar]
  15. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  16. Lombardi B., Estes L. W., Longnecker D. S. Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet. Am J Pathol. 1975 Jun;79(3):465–480. [PMC free article] [PubMed] [Google Scholar]
  17. Lombardi B., Rao N. K. Acute hemorrhagic pancreatic necrosis in mice. Influence of the age and sex of the animals and of dietary ethionine, choline, methionine, and adenine sulfate. Am J Pathol. 1975 Oct;81(1):87–100. [PMC free article] [PubMed] [Google Scholar]
  18. Rao K. N., Katyal S. L., Iammarino R. M., Lombardi B. Acute hemorrhagic pancreatic necrosis in mice. Alterations of pancreatic lipase activity, pancreas lipids, and serum lipoproteins. Digestion. 1980;20(5):314–322. doi: 10.1159/000198453. [DOI] [PubMed] [Google Scholar]
  19. Rao K. N., Tuma J., Lombardi B. Acute hemorrhagic pancreatic necrosis in mice. Intraparenchymal activation of zymogens, and other enzyme changes in pancreas and serum. Gastroenterology. 1976 May;70(5 PT1):720–726. [PubMed] [Google Scholar]
  20. Rao K. N., Zuretti M. F., Baccino F. M., Lombardi B. Acute hemorrhagic pancreatic necrosis in mice: the activity of lysosomal enzymes in the pancreas and the liver. Am J Pathol. 1980 Jan;98(1):45–59. [PMC free article] [PubMed] [Google Scholar]
  21. Sandberg A. A., Kirdani R. Y., Varkarakis M. J., Murphy G. P. Estrogen receptor protein of pancreas. Steroids. 1973 Aug;22(2):259–271. doi: 10.1016/0039-128x(73)90090-1. [DOI] [PubMed] [Google Scholar]
  22. Sandberg A. A., Rosenthal H. E. Steroid receptors in exocrine glands: the pancreas and prostate. J Steroid Biochem. 1979 Jul;11(1A):293–299. doi: 10.1016/0022-4731(79)90311-x. [DOI] [PubMed] [Google Scholar]
  23. Sloane B. F. Lysosomal apparatus in uterine muscle: effects of estrogen and of ovariectomy. Biol Reprod. 1980 Nov;23(4):867–876. doi: 10.1095/biolreprod23.4.867. [DOI] [PubMed] [Google Scholar]
  24. ULLBERG S., BENGTSSON G. Autoradiographic distribution studies with natural oestrogens. Acta Endocrinol (Copenh) 1963 May;43:75–86. doi: 10.1530/acta.0.0430075. [DOI] [PubMed] [Google Scholar]

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