Abstract
Previous studies have demonstrated pathologic similarities between human melanoma and the spontaneous melanoma in the Sinclair miniature swine (SMS) with respect to cutaneous histologic features and patterns of metastasis. The current biopsy series, correlating growth curves and histopathologic features of cutaneous melanomas, was undertaken for documentation of the histologic events associated with the successful regression of melanoma in the SMS. Cutaneous growth and regression was characterized by a series of cellular events that eventually led to depigmentation and scar formation. Mononuclear inflammatory infiltrates, seen in over half of the 104 biopsies, showed several temporal and topographic distribution patterns, similar to that described in human melanoma. Histopathologic observations in the SMS confirm clinical observations that the host can, with consistent effectiveness, react with the tumors to modify their biologic aggressiveness. Although regression is associated with lymphocytic and macrophage infiltration, the exact role of the immune response in the regression of the cutaneous melanoma remains to be elucidated.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aultman M. D., Hook R. R., Jr In vitro lymphocyte reactivity to soluble tumor extracts in Sinclair melanoma swine. Int J Cancer. 1979 Nov 15;24(5):673–678. doi: 10.1002/ijc.2910240523. [DOI] [PubMed] [Google Scholar]
- Berkelhammer J., Caines S. M., Dexter D. L., Adelstein E. H., Oxenhandler R. W., Hook R. R., Jr Adaptation of Sinclair swine melanoma cells to long-term growth in vitro. Cancer Res. 1979 Dec;39(12):4960–4964. [PubMed] [Google Scholar]
- Berkelhammer J., Ensign B. M., Hook R. R., Jr, Hecker C. J., Smith G. D., Oxenhandler R. W. Growth and spontaneous regression of swine melanoma: relationship of in vitro leukocyte reactivity. J Natl Cancer Inst. 1982 Mar;68(3):461–468. [PubMed] [Google Scholar]
- Berkelhammer J., Hook R. R., Jr Growth of Sinclair swine melanoma in the hamster cheek pouch. Transplantation. 1980 Mar;29(3):193–195. doi: 10.1097/00007890-198003000-00005. [DOI] [PubMed] [Google Scholar]
- Hook R. R., Jr, Berkelhammer J., Oxenhandler R. W. Melanoma: Sinclair swine melanoma. Am J Pathol. 1982 Jul;108(1):130–133. [PMC free article] [PubMed] [Google Scholar]
- Lipkin G., Knecht M. E. A diffusible factor restoring contact inhibition of growth to malignant melanocytes. Proc Natl Acad Sci U S A. 1974 Mar;71(3):849–853. doi: 10.1073/pnas.71.3.849. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGovern V. J. Spontaneous regression of melanoma. Pathology. 1975 Apr;7(2):91–99. doi: 10.3109/00313027509092702. [DOI] [PubMed] [Google Scholar]
- Oxenhandler R. W., Adelstein E. H., Haigh J. P., Hook R. R., Jr, Clark W. H., Jr Malignant melanoma in the Sinclair miniature swine: an autopsy study of 60 cases. Am J Pathol. 1979 Sep;96(3):707–720. [PMC free article] [PubMed] [Google Scholar]
- Silagi S. Reversible suppression of malignancy and differentiation of melanoma cells. Am J Pathol. 1977 Dec;89(3):671–684. [PMC free article] [PubMed] [Google Scholar]