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. 1985 Jun;85(2):361–365. doi: 10.1111/j.1476-5381.1985.tb08869.x

The effects of the combined administration of beta-adrenoceptor antagonists and non-steroidal anti-inflammatory drugs on ligation-induced arrhythmias in rats.

O Fagbemi
PMCID: PMC1916597  PMID: 2862943

Abstract

Pretreatment of anaesthetized rats with intravenously administered beta-adrenoceptor antagonists or non-steroidal anti-inflammatory drugs (NSAIDs) reduced the incidence and severity of ventricular arrhythmia which resulted from acute coronary artery ligation. The beta-adrenoceptor antagonists preferentially suppressed the immediate (Phase 1A) arrhythmia while the NSAIDs suppressed the delayed (Phase 1B) arrhythmias. Combined administration of beta-adrenoceptor antagonists and the NSAIDs produced a more pronounced antiarrhythmic effect than either of the drugs alone.

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Selected References

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