Abstract
The effects of the stereoisomers of two different antagonists at opioid receptors were examined on the ventricular arrhythmias that result from acute coronary artery ligation in anaesthetized male rats. (-)-Mr 1452(but not the (+)-isomer, Mr 1453) reduced, in a dose-dependent manner, the number of ventricular ectopic beats and the incidence or duration of both ventricular tachycardia and fibrillation. (-)-WIN 44,441-3 (but not its (+)-isomer, WIN 44,441-2) had a similar protective effect in ischaemia. These results suggest that antagonism of the effects of endogenous opioid peptides at specific receptors results in reduced severity of arrhythmias in myocardial ischaemia.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Clark C., Foreman M. I., Kane K. A., McDonald F. M., Parratt J. R. Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size. J Pharmacol Methods. 1980 Jun;3(4):357–368. doi: 10.1016/0160-5402(80)90077-7. [DOI] [PubMed] [Google Scholar]
- Fagbemi O., Kane K. A., Leprán I., Parratt J. R., Szekeres L. Antiarrhythmic actions of meptazinol, a partial agonist at opiate receptors, in acute myocardial ischaemia. Br J Pharmacol. 1983 Mar;78(3):455–460. doi: 10.1111/j.1476-5381.1983.tb08805.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fagbemi O., Leprán I., Parratt J. R., Szekeres L. Naloxone inhibits early arrhythmias resulting from acute coronary ligation. Br J Pharmacol. 1982 Aug;76(4):504–506. doi: 10.1111/j.1476-5381.1982.tb09246.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Von Kügelgen I., Illes P., Wolf D., Starke K. Presynaptic inhibitory opioid delta- and kappa-receptors in a branch of the rabbit ileocolic artery. Eur J Pharmacol. 1985 Nov 26;118(1-2):97–105. doi: 10.1016/0014-2999(85)90667-3. [DOI] [PubMed] [Google Scholar]
- Ward S. J., Pierson A. K., Michne W. F. Multiple opioid receptor profile in vitro and activity in vivo of the potent opioid antagonist Win 44,441-3. Life Sci. 1983;33 (Suppl 1):303–306. doi: 10.1016/0024-3205(83)90503-9. [DOI] [PubMed] [Google Scholar]