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. 1986 Oct;89(2):385–388. doi: 10.1111/j.1476-5381.1986.tb10271.x

Effects of alpha-adrenoceptor agonists and antagonists on ouabain-induced arrhythmias and cardiac arrest in guinea-pig.

G P Thomas, R M Tripathi
PMCID: PMC1917025  PMID: 2877699

Abstract

Effects of alpha-adrenoceptor agonists and antagonists with different affinity for alpha 1- and alpha 2-receptors on ouabain-induced arrhythmias in guinea-pigs were studied. Early arrhythmias, ventricular fibrillation and cardiac arrest were induced in anaesthetized guinea-pigs by the slow intravenous infusion of ouabain. Phenylephrine and yohimbine potentiated the cardiotoxicity of ouabain significantly whereas prazosin and clonidine showed significant antiarrhythmic effects and delayed the cardiac arrest. It is concluded that selective alpha 1-receptor stimulation and alpha 2-receptor blockade increases the cardiotoxic effects of ouabain and selective alpha 2-receptor stimulation and alpha 1-receptor blockade inhibits ouabain-induced arrhythmias and cardiac arrest in guinea-pigs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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