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. 1986 May;88(1):149–153. doi: 10.1111/j.1476-5381.1986.tb09481.x

The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs.

M F Fitzgerald, S Moncada, L Parente
PMCID: PMC1917123  PMID: 3708213

Abstract

The release of platelet-activating factor (Paf-acether) and of its inactive precursor/metabolite lyso-platelet activating factor (lyso-Paf) from control and sensitized guinea-pig isolated lungs challenged with antigen was investigated. Control guinea-pig lungs perfused either through the pulmonary circulation or through the airways and challenged with antigen did not release Paf-acether. Sensitized guinea-pig isolated lungs perfused through the pulmonary circulation and challenged with antigen released lyso-Paf but not Paf-acether. Sensitized guinea-pig isolated lungs perfused through the airways and challenged with antigen released three times more lyso-Paf and also Paf-acether. These results support a possible role for Paf-acether in respiratory anaphylaxis in the guinea-pig.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson P. Antigen-induced bronchial anaphylaxis in actively sensitized guinea-pigs. Pattern of response in relation to immunization regimen. Allergy. 1980 Jan;35(1):65–71. doi: 10.1111/j.1398-9995.1980.tb01718.x. [DOI] [PubMed] [Google Scholar]
  2. Benveniste J., Le Couedic J. P., Polonsky J., Tence M. Structural analysis of purified platelet-activating factor by lipases. Nature. 1977 Sep 8;269(5624):170–171. doi: 10.1038/269170a0. [DOI] [PubMed] [Google Scholar]
  3. Betz S. J., Lotner G. Z., Henson P. M. Generation and release of platelet-activating factor (PAF) from enriched preparations of rabbit basophils; failure of human basophils to release PAF. J Immunol. 1980 Dec;125(6):2749–2755. [PubMed] [Google Scholar]
  4. Blank M. L., Lee T., Fitzgerald V., Snyder F. A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid). J Biol Chem. 1981 Jan 10;256(1):175–178. [PubMed] [Google Scholar]
  5. Camussi G., Pawlowski I., Bussolino F., Caldwell P. R., Brentjens J., Andres G. Release of platelet activating factor in rabbits with antibody-mediated injury of the lung: the role of leukocytes and of pulmonary endothelial cells. J Immunol. 1983 Oct;131(4):1802–1807. [PubMed] [Google Scholar]
  6. Dusting G. J., Moncada S., Vane J. R. Recirculation of prostacyclin (PGI2) in the dog. Br J Pharmacol. 1978 Oct;64(2):315–320. doi: 10.1111/j.1476-5381.1978.tb17307.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Harmsen A. G., Bice D. E., Muggenburg B. A. The effect of local antibody responses on in vivo and in vitro phagocytosis by pulmonary alveolar macrophages. J Leukoc Biol. 1985 May;37(5):483–492. doi: 10.1002/jlb.37.5.483. [DOI] [PubMed] [Google Scholar]
  8. Horton E. W., Jones R. L. Prostaglandins A1,A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds. Br J Pharmacol. 1969 Nov;37(3):705–722. doi: 10.1111/j.1476-5381.1969.tb08509.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kravis T. C., Henson P. M. IgE-induced release of a platelet-activating factor from rabbit lung. J Immunol. 1975 Dec;115(6):1677–1681. [PubMed] [Google Scholar]
  10. Lefort J., Rotilio D., Vargaftig B. B. The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene. Br J Pharmacol. 1984 Jul;82(3):565–575. doi: 10.1111/j.1476-5381.1984.tb10795.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Levi R., Burke J. A., Guo Z. G., Hattori Y., Hoppens C. M., McManus L. M., Hanahan D. J., Pinckard R. N. Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig. Circ Res. 1984 Feb;54(2):117–124. doi: 10.1161/01.res.54.2.117. [DOI] [PubMed] [Google Scholar]
  12. Lichey J., Friedrich T., Franke J., Nigam S., Priesnitz M., Oeff K. Pressure effects and uptake of platelet-activating factor in isolated rat lung. J Appl Physiol Respir Environ Exerc Physiol. 1984 Oct;57(4):1039–1044. doi: 10.1152/jappl.1984.57.4.1039. [DOI] [PubMed] [Google Scholar]
  13. McGuire J. C., Sun F. F. Metabolism of prostacyclin. Oxidation by rhesus monkey lung 15-hydroxyl prostaglandin dehydrogenase. Arch Biochem Biophys. 1978 Jul;189(1):92–96. doi: 10.1016/0003-9861(78)90118-2. [DOI] [PubMed] [Google Scholar]
  14. Mencia-Huerta J. M., Benveniste J. Platelet-activating factor (PAF-acether) and macrophages. II. Phagocytosis-associated release of PAF-acether from rat peritoneal macrophages. Cell Immunol. 1981 Jan 15;57(2):281–292. doi: 10.1016/0008-8749(81)90087-3. [DOI] [PubMed] [Google Scholar]
  15. Mencia-Huerta J. M., Benveniste J. Platelet-activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes. Eur J Immunol. 1979 May;9(5):409–415. doi: 10.1002/eji.1830090512. [DOI] [PubMed] [Google Scholar]
  16. Mencia-Huerta J. M., Lewis R. A., Razin E., Austen K. F. Antigen-initiated release of platelet-activating factor (PAF-acether) from mouse bone marrow-derived mast cells sensitized with monoclonal IgE. J Immunol. 1983 Dec;131(6):2958–2964. [PubMed] [Google Scholar]
  17. Parente L., Fitzgerald M., De Nucci G., Moncada S. The release of lyso-PAF from guinea-pig lungs. Eur J Pharmacol. 1985 Jun 7;112(2):281–284. doi: 10.1016/0014-2999(85)90511-4. [DOI] [PubMed] [Google Scholar]
  18. Parente L., Flower R. J. Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. Life Sci. 1985 Apr 1;36(13):1225–1231. doi: 10.1016/0024-3205(85)90266-8. [DOI] [PubMed] [Google Scholar]
  19. Pinckard R. N., Farr R. S., Hanahan D. J. Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils. J Immunol. 1979 Oct;123(4):1847–1857. [PubMed] [Google Scholar]
  20. Piper P. J., Vane J. R. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature. 1969 Jul 5;223(5201):29–35. doi: 10.1038/223029a0. [DOI] [PubMed] [Google Scholar]
  21. Voelkel N. F., Worthen S., Reeves J. T., Henson P. M., Murphy R. C. Nonimmunological production of leukotrienes induced by platelet-activating factor. Science. 1982 Oct 15;218(4569):286–289. doi: 10.1126/science.7123233. [DOI] [PubMed] [Google Scholar]

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