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. 1990 Dec;101(4):773–775. doi: 10.1111/j.1476-5381.1990.tb14155.x

Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors.

K Varga 1, G Kunos 1
PMCID: PMC1917857  PMID: 1964817

Abstract

Ethanol administered i.v. or into the nucleus tractus solitarii (NTS) of rats anaesthetized with urethane inhibits baroreflex bradycardia elicited by phenylephrine. This effect is prevented or reduced by pretreatment of rats with 3-mercaptopropionic acid, bicuculline, or RO 15-4513. Intra-NTS injection of muscimol also inhibits baroreflex bradycardia and causes a pressor response which is potentiated by intra-NTS ethanol. It is proposed that ethanol inhibits baroreflex bradycardia, at least in part, by potentiating the action of endogenous gamma-aminobutyric acid (GABA) at GABAA receptors in the NTS or its vicinity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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