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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1994 Aug;55(2):341–347.

Recurrent 1;17 translocations in human neuroblastoma reveal nonhomologous mitotic recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity.

H Caron 1, P van Sluis 1, N van Roy 1, J de Kraker 1, F Speleman 1, P A Voûte 1, A Westerveld 1, R Slater 1, R Versteeg 1
PMCID: PMC1918374  PMID: 8037211

Abstract

Neuroblastomas often show loss of heterozygosity of the chromosomal region 1p36 (LOH 1p), probably reflecting loss of a tumor-suppressor gene. Here we describe three neuroblastoma tumors and two cell lines in which LOH 1p results from an unbalanced translocation between the p arm of chromosome 1 and the q arm of chromosome 17. Southern blot and cytogenetic analyses show that in all cases the chromosome 17 homologue from which the 1;17 translocation was derived is still present and intact. This suggests a model in which a translocation between the short arm of chromosome 1 and the long arm of chromosome 17 takes place in the S/G2 phase of the cell cycle and results in LOH 1p. Nonhomologous mitotic recombination in the S/G2 phase is a novel mechanism of LOH.

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Selected References

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