Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1997 Aug;71(8):6230–6232. doi: 10.1128/jvi.71.8.6230-6232.1997

Upregulation of human immunodeficiency virus (HIV) replication by CD4 cross-linking in peripheral blood mononuclear cells of HIV-infected adults.

S Than 1, N Oyaizu 1, S Tetali 1, J Romano 1, M Kaplan 1, S Pahwa 1
PMCID: PMC191889  PMID: 9223523

Abstract

This study was conducted with peripheral blood mononuclear cells from 67 human immunodeficiency virus (HIV)-infected adults. It supports the hypothesis that cross-linking of CD4 molecules by HIV gp120 can result in HIV upregulation and spread of infection. Underlying mechanisms include activation of latent infection by factors in addition to, or other than, tumor necrosis factor alpha.

Full Text

The Full Text of this article is available as a PDF (102.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baier M., Werner A., Bannert N., Metzner K., Kurth R. HIV suppression by interleukin-16. Nature. 1995 Dec 7;378(6557):563–563. doi: 10.1038/378563a0. [DOI] [PubMed] [Google Scholar]
  2. Benkirane M., Hirn M., Carrière D., Devaux C. Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4. J Virol. 1995 Nov;69(11):6898–6903. doi: 10.1128/jvi.69.11.6898-6903.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chirmule N., Kalyanaraman V. S., Pahwa S. Signals transduced through the CD4 molecule on T lymphocytes activate NF-kappa B. Biochem Biophys Res Commun. 1994 Aug 30;203(1):498–505. doi: 10.1006/bbrc.1994.2210. [DOI] [PubMed] [Google Scholar]
  4. Cocchi F., DeVico A. L., Garzino-Demo A., Arya S. K., Gallo R. C., Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995 Dec 15;270(5243):1811–1815. doi: 10.1126/science.270.5243.1811. [DOI] [PubMed] [Google Scholar]
  5. Jones D. B., Armstrong N. W. Coxsackie virus and diabetes revisited. Nat Med. 1995 Apr;1(4):284–284. doi: 10.1038/nm0495-284. [DOI] [PubMed] [Google Scholar]
  6. Levy J. A., Mackewicz C. E., Barker E. Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells. Immunol Today. 1996 May;17(5):217–224. doi: 10.1016/0167-5699(96)10011-6. [DOI] [PubMed] [Google Scholar]
  7. Li Y., Kappes J. C., Conway J. A., Price R. W., Shaw G. M., Hahn B. H. Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes. J Virol. 1991 Aug;65(8):3973–3985. doi: 10.1128/jvi.65.8.3973-3985.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Maggi E., Annunziato F., Manetti R., Biagiotti R., Giudizi M. G., Ravina A., Almerigogna F., Boiani N., Alderson M., Romagnani S. Activation of HIV expression by CD30 triggering in CD4+ T cells from HIV-infected individuals. Immunity. 1995 Aug;3(2):251–255. doi: 10.1016/1074-7613(95)90094-2. [DOI] [PubMed] [Google Scholar]
  9. Nabel G., Baltimore D. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature. 1987 Apr 16;326(6114):711–713. doi: 10.1038/326711a0. [DOI] [PubMed] [Google Scholar]
  10. Oyaizu N., McCloskey T. W., Than S., Hu R., Kalyanaraman V. S., Pahwa S. Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion. Blood. 1994 Oct 15;84(8):2622–2631. [PubMed] [Google Scholar]
  11. Schmidtmayerova H., Nottet H. S., Nuovo G., Raabe T., Flanagan C. R., Dubrovsky L., Gendelman H. E., Cerami A., Bukrinsky M., Sherry B. Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):700–704. doi: 10.1073/pnas.93.2.700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tetali S. K., Oyaizu N., Paul M., Pahwa S. Human immunodeficiency virus type 1 RNA detection in peripheral blood mononuclear cells by polymerase chain reaction: enhanced sensitivity after mitogenic stimulation. AIDS Res Hum Retroviruses. 1993 Jan;9(1):77–82. doi: 10.1089/aid.1993.9.77. [DOI] [PubMed] [Google Scholar]
  13. Than S., Hu R., Oyaizu N., Romano J., Wang X., Sheikh S., Pahwa S. Cytokine pattern in relation to disease progression in human immunodeficiency virus-infected children. J Infect Dis. 1997 Jan;175(1):47–56. doi: 10.1093/infdis/175.1.47. [DOI] [PubMed] [Google Scholar]
  14. Tremblay M., Meloche S., Gratton S., Wainberg M. A., Sékaly R. P. Association of p56lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J. 1994 Feb 15;13(4):774–783. doi: 10.1002/j.1460-2075.1994.tb06320.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wang J., Stohlman S. A., Dennert G. TCR cross-linking induces CTL death via internal action of TNF. J Immunol. 1994 Apr 15;152(8):3824–3832. [PubMed] [Google Scholar]
  16. Wei X., Ghosh S. K., Taylor M. E., Johnson V. A., Emini E. A., Deutsch P., Lifson J. D., Bonhoeffer S., Nowak M. A., Hahn B. H. Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 1995 Jan 12;373(6510):117–122. doi: 10.1038/373117a0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES