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. 1965 Jul;47(1):89–123.

Histogenesis of the Hepatic Lesion in Primary Hemochromatosis: With Consideration of the Pseudo-Iron Deficient State Produced by Phlebotomies

Matthew Block, Gene Moore, P Wasi, Gabriel Haiby
PMCID: PMC1920400  PMID: 14308140

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALPER T., SAVAGE D. V., BOTHWELL T. H. Radioiron studies in a case of hemochromatosis. J Lab Clin Med. 1951 May;37(5):665–675. [PubMed] [Google Scholar]
  2. ALTHAUSEN T. L., DOIG R. K., WEIDEN S., MOTTERAM R., TURNER C. N., MOORE A. Hemochromatosis; investigation of twenty-three cases, with special reference to etiology, nutrition, iron metabolism, and studies of hepatic and pancreatic function. AMA Arch Intern Med. 1951 Nov;88(5):553–570. doi: 10.1001/archinte.1951.03810110003001. [DOI] [PubMed] [Google Scholar]
  3. BAINTON D. F., FINCH C. A. THE DIAGNOSIS OF IRON DEFICIENCY ANEMIA. Am J Med. 1964 Jul;37:62–70. doi: 10.1016/0002-9343(64)90212-8. [DOI] [PubMed] [Google Scholar]
  4. BANNERMAN R. M., GRINSTEIN M., MOORE C. V. Haemoglobin synthesis in thalassaemia; in-vitro studies. Br J Haematol. 1959 Jan;5(1):102–120. doi: 10.1111/j.1365-2141.1959.tb04016.x. [DOI] [PubMed] [Google Scholar]
  5. BEUTLER E., DRENNAN W., BLOCK M. The bone marrow and liver in iron-deficiency anemia; a histopathologic study of sections with special reference to the stainable iron content. J Lab Clin Med. 1954 Mar;43(3):427–439. [PubMed] [Google Scholar]
  6. BEUTLER E., ROBSON M. J., BUTTENWIESER E. A comparison of the plasma iron, iron-binding capacity, sternal marrow iron and other methods in the clinical evaluation of iron, stores. Ann Intern Med. 1958 Jan;48(1):60–82. doi: 10.7326/0003-4819-48-1-60. [DOI] [PubMed] [Google Scholar]
  7. BOTHWELL T. H., COHEN I., ABRAHAMS O. L., PEROLD S. M. A familial study in idiopathic hemochromatosis. Am J Med. 1959 Nov;27:730–738. doi: 10.1016/0002-9343(59)90189-5. [DOI] [PubMed] [Google Scholar]
  8. BOTHWELL T. H. The relationship of transfusional haemosiderosis to idiopathic haemochromatosis. S Afr J Clin Sci. 1953 Jun;4(2):53–70. [PubMed] [Google Scholar]
  9. BOTHWELL T. H., VAN DOORNWITTKAMPF H. V., DU PREEZ M. L., ALPER T. The absorption of iron; radioiron studies in idiopathic hemochromatosis, malnutritional cytosiderosis, and transfusional hemosiderosis. J Lab Clin Med. 1953 Jun;41(6):836–848. [PubMed] [Google Scholar]
  10. BOTHWELL T. H., VAN LINGEN B., ALPER T., DU PREEZ M. L. The cardiac complications of hemochromatosis; report of a case including radioiron studies and a note on etiology. Am Heart J. 1952 Mar;43(3):333–340. doi: 10.1016/0002-8703(52)90079-3. [DOI] [PubMed] [Google Scholar]
  11. BROWN E. B., Jr, DUBACH R., SMITH D. E., REYNAFARJE C., MOORE C. V. Studies in iron transportation and metabolism. X. Long-term iron overload in dogs. J Lab Clin Med. 1957 Dec;50(6):862–893. [PubMed] [Google Scholar]
  12. BRUNNER H. E., FRICK P. G., HITZIG W. H. [Familial hemochromatosis-demonstration of the metabolic disorder at an early stage with Fe59]. Schweiz Med Wochenschr. 1962 Mar 24;92:343–349. [PubMed] [Google Scholar]
  13. Bradlow B. A., Dunn J. A., Higginson J. The Effect of Cirrhosis on Iron Storage. Am J Pathol. 1961 Aug;39(2):221–237. [PMC free article] [PubMed] [Google Scholar]
  14. COHEN I., BOTHWELL T. H. Haemochromatosis in a young female. S Afr Med J. 1958 Jun 21;32(25):629–631. [PubMed] [Google Scholar]
  15. CROSBY W. H. Treatment of haemochromatosis by energetic phlebotomy; one patient's response to the letting of 55 litres of blood in 11 months. Br J Haematol. 1958 Jan;4(1):82–88. doi: 10.1111/j.1365-2141.1958.tb03836.x. [DOI] [PubMed] [Google Scholar]
  16. DAVIS W. D., Jr, ARROWSMITH W. R. The effect of repeated phlebotomies in hemochromatosis; report of three cases. J Lab Clin Med. 1952 Apr;39(4):526–532. [PubMed] [Google Scholar]
  17. DEBRE R., SCHAPIRA F., DREYFUS J. C., SCHAPIRA G., FREZAL J., LABIE D., LAMY M., MAROTEAUX P. Genetics of haemochromatosis. Ann Hum Genet. 1958 Nov;23(1):16–30. doi: 10.1111/j.1469-1809.1958.tb01438.x. [DOI] [PubMed] [Google Scholar]
  18. DUBIN I. N. Idiopathic hemochromatosis and transfusion siderosis; a review. Am J Clin Pathol. 1955 May;25(5):514–542. doi: 10.1093/ajcp/25.5.514. [DOI] [PubMed] [Google Scholar]
  19. DUFFY T. J., MEISTER L. HEMOCHROMATOSIS. REPORT OF A CASE FOLLOWED FOR SEVEN YEARS WITH REPEATED PHLEBOTOMIES AND LIVER BIOPSIES. Am J Med. 1963 Sep;35:434–438. doi: 10.1016/0002-9343(63)90187-6. [DOI] [PubMed] [Google Scholar]
  20. ELLIS J. T., SCHULMAN I., SMITH C. H. Generalized siderosis with fibrosis of liver and pancreas in Cooley's (Mediterranean) anemia; with observations on the pathogenesis of the siderosis and fibrosis. Am J Pathol. 1954 Mar-Apr;30(2):287–309. [PMC free article] [PubMed] [Google Scholar]
  21. ERMANS A., PIRART J. Mesure du volume sanguin dans l'hemochromatose. Presse Med. 1953 Sep 12;61(57):1155–1155. [PubMed] [Google Scholar]
  22. FINCH C. A., HEGSTED M., KINNEY T. D., THOMAS E. D., RATH C. E., HASKINS D., FINCH S., FLUHARTY R. G. Iron metabolism; the pathophysiology of iron storage. Blood. 1950 Nov;5(11):983–1008. [PubMed] [Google Scholar]
  23. FINCH S. C., BARNETT R. N. Diagnostic and therapeutic phlebotomy in hemochromatosis with anemia; report of a case. N Engl J Med. 1957 May 9;256(19):884–887. doi: 10.1056/NEJM195705092561904. [DOI] [PubMed] [Google Scholar]
  24. FINCH S. C., FINCH C. A. Idiopathic hemochromatosis, an iron storage disease. A. Iron metabolism in hemochromatosis. Medicine (Baltimore) 1955 Dec;34(4):381–430. doi: 10.1097/00005792-195512000-00001. [DOI] [PubMed] [Google Scholar]
  25. FINCH S., HASKINS D., FINCH C. A. Iron metabolism; hematopoiesis following phlebotomy; iron as a limiting factor. J Clin Invest. 1950 Aug;29(8):1078–1086. doi: 10.1172/JCI102339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. FREY W. G., 3rd, MILNE J., JOHNSON G. B., Jr, EBAUGH F. G., Jr Management of familial hemochromatosis. N Engl J Med. 1961 Jul 6;265:7–12. doi: 10.1056/NEJM196107062650102. [DOI] [PubMed] [Google Scholar]
  27. FRIEDBERG C. K., GOLDMAN H. M., FIELD L. E. Study of baoterial endocarditis. Comparisons in ninety-five cases. Arch Intern Med. 1961 Jan;107:6–15. doi: 10.1001/archinte.1961.03620010010004. [DOI] [PubMed] [Google Scholar]
  28. GOLBERG L., SMITH J. P. Iron overloading and hepatic vulnerability. Am J Pathol. 1960 Feb;36:125–149. [PMC free article] [PubMed] [Google Scholar]
  29. GRINSTEIN M., BANNERMAN R. M., VAVRA J. D., MOORE C. V. Hemoglobin metabolism in thalassemia. In vivo studies. Am J Med. 1960 Jul;29:18–32. doi: 10.1016/0002-9343(60)90004-8. [DOI] [PubMed] [Google Scholar]
  30. GROBBELAAR B. G., HIGGINSON J., WALKER A. R. Hepatic fibrosis and cirrhosis in man in relation to malnutrition. Am J Pathol. 1957 Jan-Feb;33(1):29–53. [PMC free article] [PubMed] [Google Scholar]
  31. HIGGINSON J., GERRITSEN T., WALKER A. R. Siderosis in the Bantu of Southern Africa. Am J Pathol. 1953 Jul-Aug;29(4):779–815. [PMC free article] [PubMed] [Google Scholar]
  32. KAPLAN E., ZUELZER W. W., MOURIQUAND C. Sideroblasts: a study of stainable nonhemoglobin iron in marrow normoblasts. Blood. 1954 Mar;9(3):203–213. [PubMed] [Google Scholar]
  33. KENT G., POPPER H. Secondary hemochromatosis: its association with anemia. Arch Pathol. 1960 Nov;70:623–639. [PubMed] [Google Scholar]
  34. KLECKNER M. S., Jr, BAGGENSTOSS A. H., WEIR J. F. Hemochromatosis and transfusional hemosiderosis: a clinical and pathologic study. Am J Med. 1954 Mar;16(3):382–394. doi: 10.1016/0002-9343(54)90355-1. [DOI] [PubMed] [Google Scholar]
  35. KLECKNER M. S., Jr, KARK R. M., BAKER L. A., CHAPMAN A. Z., KAPLAN E., MOORE T. J. Clinical features, pathology, and therapy of hemochromatosis. J Am Med Assoc. 1955 Apr 23;157(17):1471–1476. doi: 10.1001/jama.1955.02950340001001. [DOI] [PubMed] [Google Scholar]
  36. LIND A. Treatment of hemochromatosis with phlebotomy of 35,000 cc. of blood. N Y State J Med. 1957 Dec 15;57(24):4027–4031. [PubMed] [Google Scholar]
  37. MACDONALD R. A. Experimental pigment cirrhosis: its production in rats by feeding a choline-deficient diet with excess iron. Am J Pathol. 1960 May;36:499–519. [PMC free article] [PubMed] [Google Scholar]
  38. MACDONALD R. A., MALLORY G. K. Hemochromatosis and hemosiderosis. Study of 211 autopsied cases. Arch Intern Med. 1960 May;105:686–700. [PubMed] [Google Scholar]
  39. MALASSENET R. Les anémies hypochromes avec hypersidérémie. Sang. 1958;29(6):486–492. [PubMed] [Google Scholar]
  40. MENDEL G. A. IRON METABOLISM AND ETIOLOGY OF IRON-STORAGE DISEASES; AN INTERPRETIVE FORMULATION. JAMA. 1964 Jul 6;189:45–53. doi: 10.1001/jama.1964.03070010051011. [DOI] [PubMed] [Google Scholar]
  41. McCreery A. H. Diabetes Associated with Haemochromatosis. Can Med Assoc J. 1917 Jun;7(6):481–502. [PMC free article] [PubMed] [Google Scholar]
  42. PETERSON R. E., ETTINGER R. H. Radioactive iron absorption in siderosis (hemochromatosis) of the liver. Am J Med. 1953 Oct;15(4):518–524. doi: 10.1016/0002-9343(53)90141-7. [DOI] [PubMed] [Google Scholar]
  43. PIRART J., CARPENT G. Aspect dynamiques de l'hémochromatose. Acta Gastroenterol Belg. 1955 Jan;18(1):7–24. [PubMed] [Google Scholar]
  44. PIRZIO-BIROLI G., BOTHWELL T. H., FINCH C. A. Iron absorption. II. The absorption of radioiron administered with a standard meal in man. J Lab Clin Med. 1958 Jan;51(1):37–48. [PubMed] [Google Scholar]
  45. PLATZER R. F., YOUNG L. E., YUILE C. L. Hemosiderosis resembling hemochromatosis following multiple transfusions. Acta Haematol. 1955 Sep;14(3):185–192. doi: 10.1159/000204984. [DOI] [PubMed] [Google Scholar]
  46. POLLYCOVE M., MORTIMER R. The quantitative determination of iron kinetics and hemoglobin synthesis in human subjects. J Clin Invest. 1961 May;40:753–782. doi: 10.1172/JCI104310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. SCHADE A. L., OYAMA J., REINHART R. W., MILLER J. R. Bound iron and unsaturated iron-binding capacity of serum; rapid and reliable quantitative determination. Proc Soc Exp Biol Med. 1954 Nov;87(2):443–448. doi: 10.3181/00379727-87-21407. [DOI] [PubMed] [Google Scholar]
  48. SCHWIETZER C. H. Untersuchungen über das Hämosiderin. Acta Haematol. 1953 Sep;10(3):174–179. doi: 10.1159/000204422. [DOI] [PubMed] [Google Scholar]
  49. SHODEN A., STURGEON P. Iron storage, IV. Cellular distribution of excess liver iron. Am J Pathol. 1962 Jun;40:671–683. [PMC free article] [PubMed] [Google Scholar]
  50. WAINWRIGHT J. Siderosis in the African. S Afr J Lab Clin Med. 1957 Mar;3(1):1–28. [PubMed] [Google Scholar]
  51. WARTHIN T. A., PETERSON E. W., BARR J. H., Jr The treatment of idiopathic hemochromatosis by repeated phlebotomy. Ann Intern Med. 1953 May;38(5):1066–1069. doi: 10.7326/0003-4819-38-5-1066. [DOI] [PubMed] [Google Scholar]
  52. WATSON J. R., DECKER E., LICHTMAN H. C. Hematologic studies of children with lead poisoning. Pediatrics. 1958 Jan;21(1):40–46. [PubMed] [Google Scholar]
  53. WILLIAMS R., SCHEUER P. J., SHERLOCK S. The inheritance of idiopathic haemochromatosis. A clinical and liver biopsy study of 16 families. Q J Med. 1962 Jul;31:249–265. [PubMed] [Google Scholar]
  54. ZIMMERMAN H. J., CHOMET B., KULESH M. H., McWHORTER C. A. Hepatic hemosiderin deposits. Incidence in 558 biopsies from patients with and without intrinsic hepatic disease. Arch Intern Med. 1961 Apr;107:494–503. doi: 10.1001/archinte.1961.03620040020003. [DOI] [PubMed] [Google Scholar]
  55. ZIZZA F., BLOCK M. The interrelationship of the serum iron, iron binding capacity and tissue iron. Acta Haematol. 1961 Jan;25:1–21. doi: 10.1159/000206500. [DOI] [PubMed] [Google Scholar]

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