Abstract
An open-label, dose-response study of cefpodoxime proxetil (CPD), an expanded-spectrum cephalosporin, was conducted with 58 males with uncomplicated Neisseria gonorrhoeae infections with single doses of 600, 400, 200, 100, or 50 mg of CPD administered orally by tablet. CPD eradicated N. gonorrhoeae in all 50 evaluable patients (10 per group) at all doses studied. Eight of the isolates eradicated were beta-lactamase-producing organisms. Two patients reported three side effects, nausea, vomiting, and diarrhea, which were mild and resolved without intervention or sequelae. There were no clinically remarkable drug-related changes in vital signs or clinical laboratory assays. Results show that single oral doses of CPD are an effective and well-tolerated treatment for uncomplicated N. gonorrhoeae infection in males at doses as low as 50 mg.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Borin M. T., Hughes G. S., Patel R. K., Royer M. E., Cathcart K. S. Pharmacokinetic and tolerance studies of cefpodoxime after single- and multiple-dose oral administration of cefpodoxime proxetil. J Clin Pharmacol. 1991 Dec;31(12):1137–1145. doi: 10.1002/j.1552-4604.1991.tb03686.x. [DOI] [PubMed] [Google Scholar]
- Fass R. J., Helsel V. L. In vitro activity of U-76,252 (CS-807), a new oral cephalosporin. Antimicrob Agents Chemother. 1988 Jul;32(7):1082–1085. doi: 10.1128/aac.32.7.1082. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Knapp C. C., Sierra-Madero J., Washington J. A. Antibacterial activities of cefpodoxime, cefixime, and ceftriaxone. Antimicrob Agents Chemother. 1988 Dec;32(12):1896–1898. doi: 10.1128/aac.32.12.1896. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C. H., Morris A., Kirby S. M., Shingler A. H. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother. 1972 Apr;1(4):283–288. doi: 10.1128/aac.1.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stamm W. E. Diagnosis of Neisseria gonorrhoeae and Chlamydia trachomatis infections using antigen detection methods. Diagn Microbiol Infect Dis. 1986 Mar;4(3 Suppl):93S–99S. doi: 10.1016/s0732-8893(86)80047-5. [DOI] [PubMed] [Google Scholar]
- Utsui Y., Inoue M., Mitsuhashi S. In vitro and in vivo antibacterial activities of CS-807, a new oral cephalosporin. Antimicrob Agents Chemother. 1987 Jul;31(7):1085–1092. doi: 10.1128/aac.31.7.1085. [DOI] [PMC free article] [PubMed] [Google Scholar]