Skip to main content
PMC home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1964 Jan 11;90(2):55–57.

Microaerosol Administration of Synthetic β-γ-Dipalmitoyl-L-α-Lecithin in the Respiratory Distress Syndrome: A Preliminary Report

E Robillard, Y Alarie, P Dagenais-Perusse, E Baril, A Guilbeault
PMCID: PMC1922135  PMID: 14104151

Abstract

Synthetic L-α-lecithin was administered by inhalation to 11 infants suffering from respiratory distress. The L-α-lecithin was delivered by microaerosolization, at a concentration of 0.25% in a mixture of equal volumes of propylene glycol and water. This was done with the aim of decreasing the alveolar surface tension. In eight of the treated infants who survived, the respiratory distress was alleviated. The results are inconclusive but they justify further investigation.

Full text

PDF
57

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AVERY M. E., MEAD J. Surface properties in relation to atelectasis and hyaline membrane disease. AMA J Dis Child. 1959 May;97(5 Pt 1):517–523. doi: 10.1001/archpedi.1959.02070010519001. [DOI] [PubMed] [Google Scholar]
  2. BROWN E. S., JOHNSON R. P., CLEMENTS J. A. Pulmonary surface tension. J Appl Physiol. 1959 Sep;14:717–720. doi: 10.1152/jappl.1959.14.5.717. [DOI] [PubMed] [Google Scholar]
  3. CLEMENTS J. A., BROWN E. S., JOHNSON R. P. Pulmonary surface tension and the mucus lining of the lungs: some theoretical considerations. J Appl Physiol. 1958 Mar;12(2):262–268. doi: 10.1152/jappl.1958.12.2.262. [DOI] [PubMed] [Google Scholar]
  4. CLEMENTS J. A. Surface tension of lung extracts. Proc Soc Exp Biol Med. 1957 May;95(1):170–172. doi: 10.3181/00379727-95-23156. [DOI] [PubMed] [Google Scholar]
  5. DAUTREBANDE L., BECKMANN H., WALKENHORST W. Lung deposition of fine dust particles. AMA Arch Ind Health. 1957 Sep;16(3):179–187. [PubMed] [Google Scholar]
  6. GRUENWALD P., JOHNSON R. P., HUSTEAD R. F., CLEMENTS J. A. Correlation of mechancial properties of infant lungs with surface activity of extracts. Proc Soc Exp Biol Med. 1962 Feb;109:369–371. doi: 10.3181/00379727-109-27205. [DOI] [PubMed] [Google Scholar]
  7. KLAUS M. H., CLEMENTS J. A., HAVEL R. J. Composition of surface-active material isolated from beef lung. Proc Natl Acad Sci U S A. 1961 Nov 15;47:1858–1859. doi: 10.1073/pnas.47.11.1858. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LANDAHL H. D., TRACEWELL T. N., LASSEN W. H. On the retention of airborne particulates in the human lung: II. AMA Arch Ind Hyg Occup Med. 1951 Apr;3(4):359–366. [PubMed] [Google Scholar]
  9. MEAD J. Mechanical properties of lungs. Physiol Rev. 1961 Apr;41:281–330. doi: 10.1152/physrev.1961.41.2.281. [DOI] [PubMed] [Google Scholar]
  10. PATTLE R. E., CLAIREAUX A. E., DAVIES P. A., CAMERON A. H. Inability to form a lung-lining film as a cause of the respiratory-distress syndrome in the newborn. Lancet. 1962 Sep 8;2(7254):469–473. doi: 10.1016/s0140-6736(62)90337-9. [DOI] [PubMed] [Google Scholar]
  11. PATTLE R. E. Properties, function and origin of the alveolar lining layer. Nature. 1955 Jun 25;175(4469):1125–1126. doi: 10.1038/1751125b0. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES