Abstract
The histological effects of several types of pickles and control substances were assessed by repeated suction (per os) biopsies of the gastric antrum in three healthy men. The ingestion of 30 ounces of fukujinzuke (assorted vegetables pickled in soy sauce) or of vinegared gherkins over a three-day period caused marked changes in the surface epithelium and gastric pits in all three subjects. The abnormalities consisted of loss of cellular mucus, nuclear enlargement, prominent nuclear chromatin and an increased number of mitotic figures. All control biopsies were normal, as were biopsies after the ingestion of 30 ounces of raw carrots or cucumbers over a three-day period. This study shows that eating a sufficient quantity of certain types of pickles causes marked changes in the human stomach. Peroral suction biopsy of the gastric antrum appears to be a practical method for testing the effect of various foods on the human gastric mucosa.
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- BRANDBORG L. L., RUBIN G. E., QUINTON W. E. A multipurpose instrument for suction biopsy of the esophagus, stomach, small bowel, and colon. Gastroenterology. 1959 Jul;37(1):1–16. [PubMed] [Google Scholar]
- BUELL P., DUNN J. E., Jr CANCER MORTALITY AMONG JAPANESE ISSEI AND NISEI OF CALIFORNIA. Cancer. 1965 May;18:656–664. doi: 10.1002/1097-0142(196505)18:5<656::aid-cncr2820180515>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
- GLAZUNOV M. F., SMIRNOV N. M., YUDKOVSKAYA I. L. THE STATE OF STOMACH MUCOSA IN CANCER AND SOME FOREGOING PROCESSES. Acta Unio Int Contra Cancrum. 1964;20:710–712. [PubMed] [Google Scholar]
- HAENSZEL W. Variation in incidence of and mortality from stomach cancer, with particular reference to the United States. J Natl Cancer Inst. 1958 Aug;21(2):213–262. [PubMed] [Google Scholar]
- MACDONALD W. C., TRIER J. S., EVERETT N. B. CELL PROLIFERATION AND MIGRATION IN THE STOMACH, DUODENUM, AND RECTUM OF MAN: RADIOAUTOGRAPHIC STUDIES. Gastroenterology. 1964 Apr;46:405–417. [PubMed] [Google Scholar]
- PRUDENTE A., MIRRA A. P. Gastric cancer in Japanese people living in Brazil. Acta Unio Int Contra Cancrum. 1961;17:851–857. [PubMed] [Google Scholar]
- QUISENBERRY W. B. Stomach cancer among Japanese in Hawaii and the United States mainland. Acta Unio Int Contra Cancrum. 1961;17:858–866. [PubMed] [Google Scholar]
- SMITH R. L. Recorded and expected mortality among the Japanese of the United States and Hawaii, with special reference to cancer. J Natl Cancer Inst. 1956 Oct;17(4):459–473. [PubMed] [Google Scholar]