Abstract
Four renal homotransplants were carried out between cadaver donors and four recipients, all of whom were in terminal chronic renal failure. Immune suppression was attempted with azathioprine (Imuran), actinomycin C and prednisone; no radiation was used, nor were the recipient's kidneys, spleen or thymus removed. One patient died with disseminated histoplasmosis at two weeks; another with irreversible homograft rejection at 30 days; a third patient died of septicemia after 9½ weeks with stable renal function. The fourth patient, whose transplant had been ischemic for 190 minutes and had not functioned for 2½ weeks thereafter, eventually achieved good function which remained unchanged to 7½ months. Changes in urinary enzyme excretion and in the I131 renogram and meralluride scan were of value in assessing homograft rejection.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CALNE R. Y., ALEXANDRE G. P., MURRAY J. E. A study of the effects of drugs in prolonging survival of homologous renal transplants in dogs. Ann N Y Acad Sci. 1962 Oct 24;99:743–761. doi: 10.1111/j.1749-6632.1962.tb45358.x. [DOI] [PubMed] [Google Scholar]
- GYENES L., SEHON A. H. The mechanism of the hemagglutination reaction. J Immunol. 1962 Oct;89:483–489. [PubMed] [Google Scholar]
- PIERCE J. C., VARCO R. L. Induction of tolerance to a canine renal homotransplant with 6-mercaptopurine. Lancet. 1962 Apr 14;1(7233):781–782. doi: 10.1016/s0140-6736(62)91788-9. [DOI] [PubMed] [Google Scholar]
- STARZL T. E., MARCHIORO T. L., WADDELL W. R. THE REVERSAL OF REJECTION IN HUMAN RENAL HOMOGRAFTS WITH SUBSEQUENT DEVELOPMENT OF HOMOGRAFT TOLERANCE. Surg Gynecol Obstet. 1963 Oct;117:385–395. [PMC free article] [PubMed] [Google Scholar]
- WOODRUFF M. F., NOLAN B., WILSON T. I., ROBSON J. S., LAMBIE A. T., CLARK J. G. HOMOTRANSPLANTATION OF KIDNEY IN PATIENTS TREATED BY PREOPERATIVE LOCAL IRRADIATION AND POSTOPERATIVE ADMINISTRATION OF AN ANTIMETABOLITE (IMURAN). REPORT OF SIX CASES. Lancet. 1963 Sep 28;2(7309):675–682. doi: 10.1016/s0140-6736(63)90465-3. [DOI] [PubMed] [Google Scholar]