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. 1964 Dec 5;91(23):1203–1208.

Effects of Ethamivan in Patients with Chronic Respiratory Disease

B J Sproule, Ronald L Jans, H Breitkreutz, W Mahon
PMCID: PMC1928498  PMID: 14226094

Abstract

Nineteen patients suffering from chronic respiratory disease were evaluated before, during and after ethamivan administration by serial measurement of arterial pH, pCO2, plasma ethamivan levels and alveolar ventilation. Ethamivan was administered intravenously as a single injection of 50 mg. in five patients; as an injection of 25 mg./kg. in five patients; as an intravenous injection of (a) 50 mg. over 15 minutes and (b) 150 mg. over 15 minutes in five patients; and finally as an oral dose of 300 to 500 mg. in five patients.

Plasma levels of ethamivan became unmeasurable within 15 minutes of receiving the largest dose. Alveolar ventilation increased only in patients receiving the highest intravenous dose, and no significant changes in blood gases were elicited in any patient.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARONOVITCH M., KAHANA L. M., MEAKINS J. F., PLACE R. E., LAING R. Vanillic diethylamide in the management of acute respiratory insufficiency: a preliminary report. Can Med Assoc J. 1961 Oct 14;85:875–885. [PMC free article] [PubMed] [Google Scholar]
  2. CHERNIACK R. M., YOUNG G. AN EVALUATION OF ETHAMIVAN AS A RESPIRATORY STIMULANT IN BARBITURATE INTOXICATION, AND ALVEOLAR HYPOVENTILATION IN EMPHYSEMA AND OBESITY. Ann Intern Med. 1964 Apr;60:631–640. doi: 10.7326/0003-4819-60-4-631. [DOI] [PubMed] [Google Scholar]
  3. MILLER M. J., HAND B. M., CRELLIN J. A. Pharmacologic effects of intravenous vanillic acid diethylamide in man. Clin Pharmacol Ther. 1961 Sep-Oct;2:689–691. doi: 10.1002/cpt196125689. [DOI] [PubMed] [Google Scholar]
  4. NAIMARK A., BRODOVSKY D. M., CHERNIACK R. M. The effect of a new carbonic anhydrase inhibitor (dichlorphenamide) in respiratory insufficiency. Am J Med. 1960 Mar;28:368–375. doi: 10.1016/0002-9343(60)90168-6. [DOI] [PubMed] [Google Scholar]
  5. PARKER J. C., PETERS R. M., BARNETT T. B. CARBON DIOXIDE AND THE WORK OF BREATHING. J Clin Invest. 1963 Aug;42:1362–1372. doi: 10.1172/JCI104820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. RODMAN T., FENNELLY J. F., KRAFT A. J., CLOSE H. P. Effect of ethamivan on alveolar ventilation in patients with chronic lung disease. N Engl J Med. 1962 Dec 20;267:1279–1285. doi: 10.1056/NEJM196212202672503. [DOI] [PubMed] [Google Scholar]
  7. SCHAEFER K. E. Respiratory adaptation to chronic hypercapnia. Ann N Y Acad Sci. 1963 Jun 24;109:772–782. doi: 10.1111/j.1749-6632.1963.tb13505.x. [DOI] [PubMed] [Google Scholar]
  8. TENNEY S. M., MILLER R. M. The respiratory and circulatory actions of salicylate. Am J Med. 1955 Oct;19(4):498–508. doi: 10.1016/0002-9343(55)90342-9. [DOI] [PubMed] [Google Scholar]
  9. TYLER J. M. The effect of progesterone on the respiration of patients with emphysema and hypercapnia. J Clin Invest. 1960 Jan;39:34–41. doi: 10.1172/JCI104024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. WHEELDON P. J., PERRY A. W. The use of ethamivan in the treatment of barbiturate poisoning. Can Med Assoc J. 1963 Jul 6;89:20–22. [PMC free article] [PubMed] [Google Scholar]

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