Skip to main content
PMC home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1965 Aug 28;93(9):379–386.

Polyoma-like Virions in Human Demyelinating Brain Disease

Allan F Howatson, Martha Nagai, Gabriele M Zu Rhein
PMCID: PMC1928746  PMID: 14339302

Abstract

Specimens of brain tissue obtained at autopsy from three patients suffering from progressive multifocal leukoencephalopathy (PML) were examined by electron microscopy. In specimens from all three cases particles similar to those of the papova virus group were present, confirming previous observations. By the negative staining method it was possible to define the morphological characteristics of the particles more precisely and it was shown that they are structurally similar to virions of the polyoma-SV40-K type. The need is emphasized for obtaining fresh unfixed diseased tissue from persons suffering from PML in order that the biological properties of the particles can be investigated.

Full text

PDF
381

Images in this article

381Fig. 1
on p.381
382Fig. 2
on p.382
383Figs. 3-6
on p.383
384Fig. 7
on p.384
384Fig. 8
on p.384
385Fig. 9
on p.385

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRENNER S., HORNE R. W. A negative staining method for high resolution electron microscopy of viruses. Biochim Biophys Acta. 1959 Jul;34:103–110. doi: 10.1016/0006-3002(59)90237-9. [DOI] [PubMed] [Google Scholar]
  2. CASPAR D. L., DULBECCO R., KLUG A., LWOFF A., STOKER M. G., TOURNIER P., WILDY P. Proposals. Cold Spring Harb Symp Quant Biol. 1962;27:49–50. doi: 10.1101/sqb.1962.027.001.007. [DOI] [PubMed] [Google Scholar]
  3. CAVANAGH J. B., GREENBAUM D., MARSHALL A. H., RUBINSTEIN L. J. Cerebral demyelination associated with disorders of the reticuloendothelial system. Lancet. 1959 Oct 10;2(7102):524–529. doi: 10.1016/s0140-6736(59)91774-x. [DOI] [PubMed] [Google Scholar]
  4. CRAWFORD L. V., CRAWFORD E. M. A COMPARATIVE STUDY OF POLYOMA AND PAPILLOMA VIRUSES. Virology. 1963 Oct;21:258–263. doi: 10.1016/0042-6822(63)90265-4. [DOI] [PubMed] [Google Scholar]
  5. DOLMAN C. L., CAIRNS A. R. Leukoencephalopathy associated with Hodgkin's disease. Neurology. 1961 Apr;11(4):349–353. doi: 10.1212/wnl.11.4.349. [DOI] [PubMed] [Google Scholar]
  6. HOWATSON A. F., ALMEIDA J. D. An electron microscope study of polyoma virus in hamster kidney. J Biophys Biochem Cytol. 1960 Jul;7:753–760. doi: 10.1083/jcb.7.4.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MELNICK J. L. Papova virus group. Science. 1962 Mar 30;135(3509):1128–1130. doi: 10.1126/science.135.3509.1128. [DOI] [PubMed] [Google Scholar]
  8. RICHARDSON E. P., Jr LEUCO-ENC'EPHALOPATHIE MULTIFOCALE PROGRESSIVE. Rev Med Suisse Romande. 1964 Feb;84:126–136. [PubMed] [Google Scholar]
  9. RICHARDSON E. P., Jr Progressive multifocal leukoencephalopathy. N Engl J Med. 1961 Oct 26;265:815–823. doi: 10.1056/NEJM196110262651701. [DOI] [PubMed] [Google Scholar]
  10. WAKSMAN B. H., ADAMS R. D. Infectious leukoencephalitis. A critical comparison of certain experimental and naturally-occurring viral leukoencephalitides with experimental allergic encephalomyelitis. J Neuropathol Exp Neurol. 1962 Oct;21:491–518. [PubMed] [Google Scholar]
  11. WEINSTEIN V. F., WOOLF A. L., MEYNELL M. J. PROGRESSIVE MULTIFOCAL LEUCOENCEPHALOPATHY AND PRIMARY HYPERSPLENISM. WITH A NOTE ON THE ASSOCIATION BETWEEN DISEASE OF THE RETICULOENDOTHELIAL SYSTEM AND PROGRESSIVE MULTIFOCAL LEUCOENCEPHALOPATHY. J Clin Pathol. 1963 Sep;16:405–418. doi: 10.1136/jcp.16.5.405. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES