Abstract
The case records were studied of all 48 patients with miliary tuberculosis registered by the British Columbia Division of Tuberculosis Control between 1967 and 1971. Two groups of patients were found, one group of 30 in whom the diagnosis was made during life and antituberculous therapy instituted, and a second group of 18 patients in whom the diagnosis was made only at autopsy and who had received no antituberculous therapy. In the latter group there was a particularly high incidence of concomitant disease; additionally, tuberculin testing, bacteriological search for acid-fast bacilli and chest radiography were frequently neglected. This group consisted mainly of elderly male Caucasians. The disease was characteristically insidious in onset, frequently with non-specific symptoms and physical findings. Fever was a common presenting symptom. Several patients presented with a fulminant illness which, although diagnosed, was not affected by antituberculous therapy and was rapidly fatal. North American Indians showed a high incidence of disease but a low mortality rate, probably owing to their younger age.
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- Ashba J. K., Boyce J. M. Undiagnosed tuberculosis in a general hospital. Chest. 1972 May;61(5):447–451. doi: 10.1378/chest.61.5.447. [DOI] [PubMed] [Google Scholar]
- BIEHL J. P. Miliary tuberculosis; a review of sixty-eight adult patients admitted to a municipal general hospital. Am Rev Tuberc. 1958 Apr;77(4):605–622. doi: 10.1164/artpd.1958.77.4.605. [DOI] [PubMed] [Google Scholar]
- BOTTIGER L. E. Fever of unknown origin. III. The final diagnosis in patients admitted as cases of fever of unknown origin. Acta Med Scand. 1957 Feb 2;156(6):469–476. [PubMed] [Google Scholar]
- BOTTIGER L. E., NORDENSTAM H. H., WESTER P. O. Disseminated tuberculosis as a cause of fever of obscure origin. Lancet. 1962 Jan 6;1(7219):19–20. doi: 10.1016/s0140-6736(62)92641-7. [DOI] [PubMed] [Google Scholar]
- Berger H. W., Samortin T. G. Miliary tuberculosis: diagnostic methods with emphasis on the chest roentgenogram. Chest. 1970 Dec;58(6):586–589. doi: 10.1378/chest.58.6.586. [DOI] [PubMed] [Google Scholar]
- DOERNER A. A., NAEGELE C. F., REGAN F. D., CAMERON G. F. The development of tuberculous meningitis following cortisone therapy. Am Rev Tuberc. 1951 Nov;64(5):564–571. doi: 10.1164/art.1951.64.5.564. [DOI] [PubMed] [Google Scholar]
- Fullerton J. M. Unsuspected miliary tuberculosis. Br Med J. 1969 Mar 15;1(5645):715–715. doi: 10.1136/bmj.1.5645.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Galbraith J. D., Grzybowski S., Law C. L., Rowe J. Tuberculosis in Indian children: primary pulmonary tuberculosis. Can Med Assoc J. 1969 Mar 15;100(11):497–502. [PMC free article] [PubMed] [Google Scholar]
- HEINLE E. W., Jr, JENSEN W. N., WESTERMAN M. P. DIAGNOSTIC USEFULNESS OF MARROW BIOPSY IN DISSEMINATED TUBERCULOSIS. Am Rev Respir Dis. 1965 May;91:701–705. doi: 10.1164/arrd.1965.91.5.701. [DOI] [PubMed] [Google Scholar]
- Heaton J., McCaughey W. T. Miliary tuberculosis in adults. Ir J Med Sci. 1971 Jun;140(6):251–257. doi: 10.1007/BF02942261. [DOI] [PubMed] [Google Scholar]
- ILLINGWORTH R. S., WRIGHT T. Tubercles of the choroid. Br Med J. 1948 Aug 21;2(4572):365–368. doi: 10.1136/bmj.2.4572.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacques J., Sloan J. M. The changing pattern of miliary tuberculosis. Thorax. 1970 Mar;25(2):237–240. doi: 10.1136/thx.25.2.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Justin-Besançon L., Chrétien J., Grivaux M., Baguet J. C., Delavierre P. Tuberculoses mortelles et tuberculoses méconnues. Conclusions générales. Sem Hop. 1966 Apr 14;42(25):1125–1131. [PubMed] [Google Scholar]
- OSWALD N. C. ACUTE TUBERCULOSIS AND GRANULOCYTIC DISORDERS. Br Med J. 1963 Dec 14;2(5371):1489–1496. doi: 10.1136/bmj.2.5371.1489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PETERSDORF R. G., BEESON P. B. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore) 1961 Feb;40:1–30. doi: 10.1097/00005792-196102000-00001. [DOI] [PubMed] [Google Scholar]
- TREIP C., MEYERS D. Fatal tuberculosis in a general hospital; a diagnostic problem. Lancet. 1959 Jan 24;1(7065):164–166. doi: 10.1016/s0140-6736(59)90366-6. [DOI] [PubMed] [Google Scholar]