Skip to main content
PMC home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1975 Apr 19;112(8):943–947.

Plasma progesterone and aldosterone in pregnancy.

F Ledoux, J Genest, W Nowaczynski, O Kuchel, M Lebel
PMCID: PMC1956068  PMID: 1131766

Abstract

Plasma progesterone, aldosterone and renin activity were measured simultaneously in seven women during normal pregnancy. Beginning at the 2nd trimester and until approximately 4 weeks before delivery there was a constant increase in plasma progesterone concentration. There was a significant correlation between weight gain and duration of pregnancy and between weight gain and plasma progesterone concentration. There was also an increase in plasma aldosterone concentration although this was less consistent than that of progesterone. And there was a significant correlation between plasma progesterone and aldosterone concentrations and between the progesterone/aldosterone ratio and duration of pregnancy and weight gain.

Full text

PDF
947

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS E. M., FINLAYSON A. Familial aspects of pre-eclampsia and hypertension in pregnancy. Lancet. 1961 Dec 23;2(7217):1375–1378. doi: 10.1016/s0140-6736(61)91197-7. [DOI] [PubMed] [Google Scholar]
  2. ARMSTRONG J. G. Hypotensive action of progesterone in experimental and human hypertension. Proc Soc Exp Biol Med. 1959 Nov;102:452–455. doi: 10.3181/00379727-102-25282. [DOI] [PubMed] [Google Scholar]
  3. BOUCHER R., VEYRAT R., DE CHAMPLAIN J., GENEST J. NEW PROCEDURES FOR MEASUREMENT OF HUMAN PLASMA ANGIOTENSIN AND RENIN ACTIVITY LEVELS. Can Med Assoc J. 1964 Jan 25;90:194–201. [PMC free article] [PubMed] [Google Scholar]
  4. Bauer G. E. Hypertension and pregnancy. Med J Aust. 1972 Oct 28;2(18):989–990. [PubMed] [Google Scholar]
  5. EHRLICH E. N., LAVES M., LUGIBIHL K., LANDAU R. L. Progesterone-aldosterone interrelationships in pregnancy. J Lab Clin Med. 1962 Apr;59:588–595. [PubMed] [Google Scholar]
  6. JONES K. M., LLOYD-JONES R., RIONDEL A., TAIT J. F., TAIT S. A., BULBROOK R. D., GREENWOOD F. C. Aldosterone secretion and metabolism in normal men and women and in pregnancy. Acta Endocrinol (Copenh) 1959 Mar;30(3):321–342. doi: 10.1530/acta.0.0300321. [DOI] [PubMed] [Google Scholar]
  7. KLOPPER A., BILLEWICZ W. URINARY EXCRETION OF OESTRIOL AND PREGNANEDIOL DURING NORMAL PREGNANCY. J Obstet Gynaecol Br Commonw. 1963 Dec;70:1024–1033. doi: 10.1111/j.1471-0528.1963.tb15047.x. [DOI] [PubMed] [Google Scholar]
  8. MARTIN J. D., MILLS I. H. Aldosterone excretion in normal and toxaemic pregnancies. Br Med J. 1956 Sep 8;2(4992):571–573. doi: 10.1136/bmj.2.4992.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Munnell E. W., Taylor H. C. LIVER BLOOD FLOW IN PREGNANCY-HEPATIC VEIN CATHETERIZATION. J Clin Invest. 1947 Sep;26(5):952–956. doi: 10.1172/JCI101890. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. NOWACZYNSKI W., KOIW E., GENEST J. Chemical method for the determination of urinary aldosterone. Can J Biochem Physiol. 1957 Jun;35(6):425–443. [PubMed] [Google Scholar]
  11. Newton M. A., Sealey J. E., Ledingham J. G., Laragh J. H. High blood pressure and oral contraceptives. Changes in plasma renin and renin substrate and in aldosterone excretion. Am J Obstet Gynecol. 1968 Aug 15;101(8):1037–1045. doi: 10.1016/0002-9378(68)90345-1. [DOI] [PubMed] [Google Scholar]
  12. Nowaczynski W., Sasaki C., Genest J. Radioimmunoassay for aldosterone and normal values under various physiological conditions. J Steroid Biochem. 1974 Apr;5(2):123–131. doi: 10.1016/0022-4731(74)90118-6. [DOI] [PubMed] [Google Scholar]
  13. Oelkers W., Schöneshöfer M., Blümel A. Effects of progesterone and four synthetic progestagens on sodium balance and the renin-aldosterone system in man. J Clin Endocrinol Metab. 1974 Nov;39(5):882–890. doi: 10.1210/jcem-39-5-882. [DOI] [PubMed] [Google Scholar]
  14. Robertson J. I., Weir R. J., Düsterdieck G. O., Fraser R., Tree M. Renin, angiotensin and aldosterone in human pregnancy and the menstrual cycle. Scott Med J. 1971 Mar;16(3):183–196. doi: 10.1177/003693307101600303. [DOI] [PubMed] [Google Scholar]
  15. Sasaki C., Nowaczynski W., Kuchel O., Chavez C., Ledoux F., Gauthier S., Genest J. Plasma progesterone in normal subjects and patients with benign essential hypertension on normal, low, and high sodium intake. J Clin Endocrinol Metab. 1972 Apr;34(4):650–660. doi: 10.1210/jcem-34-4-650. [DOI] [PubMed] [Google Scholar]
  16. TAIT J. F., LITTLE B., TAIT S. A., FLOOD C. The metabolic clearance rate of aldosterone in pregnant and nonpregnant subjects estimated by both single-injection and constant-infusion methods. J Clin Invest. 1962 Dec;41:2093–2100. doi: 10.1172/JCI104667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tait J. F., Little B. The metabolism of orally and intravenously administered labeled aldosterone in pregnant subjects. J Clin Invest. 1969 Nov;47(11):2423–2429. doi: 10.1172/JCI105925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Turnbull A. C., Patten P. T., Flint A. P., Keirse M. J., Jeremy J. Y., Anderson A. B. Significant fall in progesterone and rise in oestradiol levels in human peripheral plasma before onset of labour. Lancet. 1974 Jan 26;1(7848):101–103. doi: 10.1016/s0140-6736(74)92337-x. [DOI] [PubMed] [Google Scholar]
  19. VENNING E. H., PRIMROSE T., CALIGARIS L. C., DYRENFURTH I. Aldosterone excretion in pregnancy. J Clin Endocrinol Metab. 1957 Apr;17(4):473–482. doi: 10.1210/jcem-17-4-473. [DOI] [PubMed] [Google Scholar]
  20. Weir R. J., Paintin D. B., Brown J. J., Fraser R., Lever A. F., Robertson J. I., Young J. A serial study in pregnancy of the plasma concentrations of renin, corticosteroids, electrolytes and proteins and of haematocrit and plasma volume. J Obstet Gynaecol Br Commonw. 1971 Jul;78(7):590–602. doi: 10.1111/j.1471-0528.1971.tb00321.x. [DOI] [PubMed] [Google Scholar]
  21. Weir R. J., Paintin D. B., Robertson J. I., Tree M., Fraser R., Young J. Renin, angiotensin and aldosterone relationships in normal pregnancy. Proc R Soc Med. 1970 Nov;63(11 Pt 1):1101–1102. [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES