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British Journal of Cancer logoLink to British Journal of Cancer
. 1993 Aug;68(2):414–417. doi: 10.1038/bjc.1993.351

Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma.

C Blomqvist 1, T Wiklund 1, M Tarkkanen 1, I Elomaa 1, M Virolainen 1
PMCID: PMC1968540  PMID: 8347499

Abstract

The volume doubling time (T2) of 52 lung metastases in 21 patients was calculated from measurements done on plain chest radiographs. Follow-up times ranged from 14 to 819 days. The measurements were fairly well reproducible in the majority of patients, although considerable discrepancies in T2 estimates made by two independent observers were found in a few patients. The median doubling time was 34.9 days (estimated 95% range 3.9 to 352 days). The variation of T2:s between patients was significantly (P = 0.0001) larger than that between T2: of multiple metastases in the same patients. The growth of the metastases seemed to be well described by a simple exponential function in all patients with more than two measurements, without evidence of Gompertzian growth. There seemed to be a linear correlation between the logarithm of T2 and log-survival time from diagnosis of metastatic disease, even if only one third of the variation of survival times between patients could be explained by differences in T2. T2 was not a significant factor for survival in Cox-analysis (P = 0.10).

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Selected References

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  1. Band P. R., Kocandrle C. Growth rate of pulmonary metastases in human sarcomas. Cancer. 1975 Aug;36(2):471–474. doi: 10.1002/1097-0142(197508)36:2<471::aid-cncr2820360225>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  2. Brennan P., Silman A. Statistical methods for assessing observer variability in clinical measures. BMJ. 1992 Jun 6;304(6840):1491–1494. doi: 10.1136/bmj.304.6840.1491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brenner M. W., Holsti L. R., Perttala Y. The study by graphical analysis of the growth of human tumours and metastases of the lung. Br J Cancer. 1967 Mar;21(1):1–13. doi: 10.1038/bjc.1967.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COLLINS V. P., LOEFFLER R. K., TIVEY H. Observations on growth rates of human tumors. Am J Roentgenol Radium Ther Nucl Med. 1956 Nov;76(5):988–1000. [PubMed] [Google Scholar]
  5. Chahinian P. Relationship between tumor doubling time and anatomoclinical features in 50 measurable pulmonary cancers. Chest. 1972 Apr;61(4):340–345. doi: 10.1378/chest.61.4.340. [DOI] [PubMed] [Google Scholar]
  6. Charbit A., Malaise E. P., Tubiana M. Relation between the pathological nature and the growth rate of human tumors. Eur J Cancer. 1971 Aug;7(4):307–315. doi: 10.1016/0014-2964(71)90073-9. [DOI] [PubMed] [Google Scholar]
  7. Joseph W. L., Morton D. L., Adkins P. C. Prognostic significance of tumor doubling time in evaluating operability in pulmonary metastatic disease. J Thorac Cardiovasc Surg. 1971 Jan;61(1):23–32. [PubMed] [Google Scholar]
  8. LAIRD A. K. DYNAMICS OF TUMOR GROWTH. Br J Cancer. 1964 Sep;13:490–502. doi: 10.1038/bjc.1964.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LAIRD A. K. DYNAMICS OF TUMOUR GROWTH: COMPARISON OF GROWTH RATES AND EXTRAPOLATION OF GROWTH CURVE TO ONE CELL. Br J Cancer. 1965 Jun;19:278–291. doi: 10.1038/bjc.1965.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mattson K., Holsti L. R. Prognostic value of doubling time in lung cancer. Strahlentherapie. 1980 Sep;156(9):632–636. [PubMed] [Google Scholar]
  11. Röser B., Pettersson H., Alvegård T. Growth rate of pulmonary metastases from soft tissue sarcoma. Acta Oncol. 1987;26(3):189–192. doi: 10.3109/02841868709091429. [DOI] [PubMed] [Google Scholar]
  12. SCHWARTZ M. A biomathematical approach to clinical tumor growth. Cancer. 1961 Nov-Dec;14:1272–1294. doi: 10.1002/1097-0142(196111/12)14:6<1272::aid-cncr2820140618>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  13. SPRATT J. S., Jr, SPRATT T. L. RATES OF GROWTH OF PULMONARY METASTASES AND HOST SURVIVAL. Ann Surg. 1964 Feb;159:161–171. doi: 10.1097/00000658-196402000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]

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