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. 1994 Nov;176(22):7115–7117. doi: 10.1128/jb.176.22.7115-7117.1994

The leader peptides of attenuation-regulated chloramphenicol resistance genes inhibit translational termination.

J G Moffat 1, W P Tate 1, P S Lovett 1
PMCID: PMC197091  PMID: 7961481

Abstract

Placing a translation stop codon at the ribosomal pause site in the leader of the attenuation-regulated cat-86 gene activates cat expression in the absence of the inducer, chloramphenicol. Genetic experiments have shown that this phenomenon depends on the amino acid sequence of the leader-encoded peptide and could readily be explained if the peptide was an inhibitor of translation termination. Here we demonstrate that the cat-86 leader pentapeptide is an in vitro inhibitor of translation termination in addition to its previously described antipeptidyltransferase activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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