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. 1990 Mar;61(3):441–446. doi: 10.1038/bjc.1990.97

How frequent is spontaneous remission of neuroblastomas? Implications for screening.

N L Carlsen 1
PMCID: PMC1971306  PMID: 2328213

Abstract

The 'true' incidence of spontaneous regression of neuroblastomas is uncertain. However, the frequency of spontaneous regression is important when the benefits of screening procedures are considered. In the population-based Danish neuroblastoma survey 1943-80, spontaneous regression was documented in less than 2% of cases. However, the 'true' incidence may be higher. The epidemiological findings of increased incidence and survival rates with an unchanged mortality rate may suggest the inclusion of borderline lesions among 'truly' malignant neuroblastomas in recent decades in Denmark. However, it is more likely to be a result of improved diagnosis, changes in the social composition of the population and possibly unidentified environmental agents. However, if some premalignant lesions in fact had been included, they are most likely to be stages I-II tumours of infancy. In this study we describe cases of spontaneous regression of neuroblastoma from the Danish population-based survey 1943-80.

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Selected References

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  1. BECKWITH J. B., PERRIN E. V. IN SITU NEUROBLASTOMAS: A CONTRIBUTION TO THE NATURAL HISTORY OF NEURAL CREST TUMORS. Am J Pathol. 1963 Dec;43:1089–1104. [PMC free article] [PubMed] [Google Scholar]
  2. Beckwith J. B., Martin R. F. Observations on the histopathology of neuroblastomas. J Pediatr Surg. 1968 Feb;3(1):106–110. doi: 10.1016/0022-3468(68)90989-5. [DOI] [PubMed] [Google Scholar]
  3. Birch J. M., Marsden H. B., Swindell R. Incidence of malignant disease in childhood: a 24-year review of the Manchester Children's Tumour Registry data. Br J Cancer. 1980 Aug;42(2):215–223. doi: 10.1038/bjc.1980.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Carlsen N. L., Christensen I. J., Schroeder H., Bro P. V., Erichsen G., Hamborg-Pedersen B., Jensen K. B., Nielsen O. H. Prognostic factors in neuroblastomas treated in Denmark from 1943 to 1980. A statistical estimate of prognosis based on 253 cases. Cancer. 1986 Dec 15;58(12):2726–2735. doi: 10.1002/1097-0142(19861215)58:12<2726::aid-cncr2820581229>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  5. Carlsen N. L., Christensen I. J., Schroeder H., Bro P. V., Hesselbjerg U., Jensen K. B., Nielsen O. H. Prognostic value of different staging systems in neuroblastomas and completeness of tumour excision. Arch Dis Child. 1986 Sep;61(9):832–842. doi: 10.1136/adc.61.9.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Carlsen N. L. Epidemiological investigations on neuroblastomas in Denmark 1943-1980. Br J Cancer. 1986 Dec;54(6):977–988. doi: 10.1038/bjc.1986.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Carlsen N. L., Nielsen O. H. Neuroblastoma abdominis. Enanalyse af 48 tilfaelde. Ugeskr Laeger. 1980 Nov 3;142(45):2972–2975. [PubMed] [Google Scholar]
  8. Carlsen N. L., Schroeder H., Christensen I. J., Bro P. V., Hesselbjerg U., Jensen K. B., Nielsen O. H. Signs, symptoms, metastatic spread and metabolic behavior of neuroblastomas treated in Denmark during the period 1943-1980. Anticancer Res. 1987 May-Jun;7(3 Pt B):465–473. [PubMed] [Google Scholar]
  9. Carlsen N. L. Why age has independent prognostic significance in neuroblastomas. Evidence for intra-uterine development, and implications for the treatment of the disease. Anticancer Res. 1988 Mar-Apr;8(2):255–262. [PubMed] [Google Scholar]
  10. Cheson B. D., Jasperse D. M., Chun H. G., Friedman M. A. Differentiating agents in the treatment of human malignancies. Cancer Treat Rev. 1986 Sep;13(3):129–145. doi: 10.1016/0305-7372(86)90001-0. [DOI] [PubMed] [Google Scholar]
  11. Draper G. J. Screening for neuroblastoma. BMJ. 1988 Jul 16;297(6642):152–153. doi: 10.1136/bmj.297.6642.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Evans A. E., Baum E., Chard R. Do infants with stage IV-S neuroblastoma need treatment? Arch Dis Child. 1981 Apr;56(4):271–274. doi: 10.1136/adc.56.4.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Evans A. E., D'Angio G. J., Randolph J. A proposed staging for children with neuroblastoma. Children's cancer study group A. Cancer. 1971 Feb;27(2):374–378. doi: 10.1002/1097-0142(197102)27:2<374::aid-cncr2820270221>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  14. Evans A. E., Gerson J., Schnaufer L. Spontaneous regression of neuroblastoma. Natl Cancer Inst Monogr. 1976 Nov;44:49–54. [PubMed] [Google Scholar]
  15. Feinstein A. R., Sosin D. M., Wells C. K. The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. N Engl J Med. 1985 Jun 20;312(25):1604–1608. doi: 10.1056/NEJM198506203122504. [DOI] [PubMed] [Google Scholar]
  16. GROSS R. E., FARBER S., MARTIN L. W. Neuroblastoma sympatheticum; a study and report of 217 cases. Pediatrics. 1959 Jun;23(6):1179–1191. [PubMed] [Google Scholar]
  17. HANSEN P. B. Sympathicoblastoma of the adrenal medulla with osseous metastases; a report of three cases including one surviving eleven years after roentgen therapy. Acta radiol. 1953 Nov;40(5):500–510. [PubMed] [Google Scholar]
  18. Hayashi Y., Inaba T., Hanada R., Yamamoto K. Chromosome findings and prognosis in 15 patients with neuroblastoma found by VMA mass screening. J Pediatr. 1988 Apr;112(4):567–571. doi: 10.1016/s0022-3476(88)80168-9. [DOI] [PubMed] [Google Scholar]
  19. Ikeda Y., Lister J., Bouton J. M., Buyukpamukcu M. Congenital neuroblastoma, neuroblastoma in situ, and the normal fetal development of the adrenal. J Pediatr Surg. 1981 Aug;16(4 Suppl 1):636–644. doi: 10.1016/0022-3468(81)90019-1. [DOI] [PubMed] [Google Scholar]
  20. Kaneko Y., Kanda N., Maseki N., Sakurai M., Tsuchida Y., Takeda T., Okabe I., Sakurai M. Different karyotypic patterns in early and advanced stage neuroblastomas. Cancer Res. 1987 Jan 1;47(1):311–318. [PubMed] [Google Scholar]
  21. Kaneko Y., Maseki N., Sakurai M., Okabe I., Takeda T., Sakurai M., Kanda N. Chromosomes and screening for neuroblastoma. Lancet. 1988 Jan 23;1(8578):174–175. doi: 10.1016/s0140-6736(88)92739-0. [DOI] [PubMed] [Google Scholar]
  22. Klein G., Klein E. Conditioned tumorigenicity of activated oncogenes. Cancer Res. 1986 Jul;46(7):3211–3224. [PubMed] [Google Scholar]
  23. Knudson A. G., Jr, Meadows A. T. Sounding board. Regression of neuroblastoma IV-S: a genetic hypothesis. N Engl J Med. 1980 May 29;302(22):1254–1256. doi: 10.1056/NEJM198005293022210. [DOI] [PubMed] [Google Scholar]
  24. Kosloske A. M., Bhattacharyya N., Duncan M. H. "Incidental" neuroblastoma. Lancet. 1987 Sep 5;2(8558):565–565. doi: 10.1016/s0140-6736(87)92946-1. [DOI] [PubMed] [Google Scholar]
  25. Mauer A. M. Screening for neuroblastoma. J Pediatr. 1988 Apr;112(4):576–577. doi: 10.1016/s0022-3476(88)80171-9. [DOI] [PubMed] [Google Scholar]
  26. Moolgavkar S. H., Knudson A. G., Jr Mutation and cancer: a model for human carcinogenesis. J Natl Cancer Inst. 1981 Jun;66(6):1037–1052. doi: 10.1093/jnci/66.6.1037. [DOI] [PubMed] [Google Scholar]
  27. Nicolson G. L. Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression. Cancer Res. 1987 Mar 15;47(6):1473–1487. [PubMed] [Google Scholar]
  28. Nishi M., Miyake H., Takeda T., Shimada M., Takasugi N., Sato Y., Hanai J. Effects of the mass screening of neuroblastoma in Sapporo City. Cancer. 1987 Aug 1;60(3):433–436. doi: 10.1002/1097-0142(19870801)60:3<433::aid-cncr2820600326>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  29. Norman M. G., Dimmick J. E., Taylor G. P., Teasdale M. Screening for neuroblastoma. Lancet. 1987 Sep 5;2(8558):565–566. doi: 10.1016/s0140-6736(87)92947-3. [DOI] [PubMed] [Google Scholar]
  30. Pastore G., Merletti F., Magnani C. Screening for neuroblastoma. Lancet. 1984 Sep 29;2(8405):752–752. doi: 10.1016/s0140-6736(84)92657-6. [DOI] [PubMed] [Google Scholar]
  31. Rechnitzer C., Hansen S. W. Differentiering af neuroblastom. Langtidsoverlevelse med multiple knoglemetastaser. Ugeskr Laeger. 1980 Nov 3;142(45):2976–2977. [PubMed] [Google Scholar]
  32. SUTOW W. W. Prognosis in neuroblastoma of childhood. AMA J Dis Child. 1958 Sep;96(3):299–305. doi: 10.1001/archpedi.1958.02060060301008. [DOI] [PubMed] [Google Scholar]
  33. Sawada T., Kawakatu H., Horii Y., Sugimoto T. Incidental neuroblastoma. Lancet. 1988 Feb 13;1(8581):364–364. doi: 10.1016/s0140-6736(88)91165-8. [DOI] [PubMed] [Google Scholar]
  34. Sawada T., Kidowaki T., Sakamoto I., Hashida T., Matsumura T., Nakagawa M., Kusunoki T. Neuroblastoma. Mass screening for early detection and its prognosis. Cancer. 1984 Jun 15;53(12):2731–2735. doi: 10.1002/1097-0142(19840615)53:12<2731::aid-cncr2820531232>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  35. Sawada T., Kidowaki T., Sugimoto T., Kusunoki T. Incidence of neuroblastoma in infancy in Japan. Med Pediatr Oncol. 1984;12(2):101–103. doi: 10.1002/mpo.2950120208. [DOI] [PubMed] [Google Scholar]
  36. Sawada T. Outcome of 25 neuroblastomas revealed by mass screening in Japan. Lancet. 1986 Feb 15;1(8477):377–377. doi: 10.1016/s0140-6736(86)92335-4. [DOI] [PubMed] [Google Scholar]
  37. Scriver C. R., Gregory D., Bernstein M., Clow C. L., Weisdorf T., Dougherty G. E., Auray-Blais C., Giguère R., Lemieux B., Laberge C. Feasibility of chemical screening of urine for neuroblastoma case finding in infancy in Quebec. CMAJ. 1987 May 1;136(9):952–956. [PMC free article] [PubMed] [Google Scholar]
  38. Turkel S. B., Itabashi H. H. The natural history of neuroblastic cells in the fetal adrenal gland. Am J Pathol. 1974 Aug;76(2):225–244. [PMC free article] [PubMed] [Google Scholar]
  39. VISFELDT J. TRANSFORMATION OF SYMPATHICOBLASTOMA INTO GANGLIONEUROMA, WITH A CASE REPORT. Acta Pathol Microbiol Scand. 1963;58:414–428. doi: 10.1111/j.1699-0463.1963.tb01589.x. [DOI] [PubMed] [Google Scholar]
  40. Wilson L. M., Draper G. J. Neuroblastoma, its natural history and prognosis: a study of 487 cases. Br Med J. 1974 Aug 3;3(5926):301–307. doi: 10.1136/bmj.3.5926.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Woods W. G., Tuchman M. Neuroblastoma: the case for screening infants in North America. Pediatrics. 1987 Jun;79(6):869–873. [PubMed] [Google Scholar]
  42. Young J. L., Jr, Ries L. G., Silverberg E., Horm J. W., Miller R. W. Cancer incidence, survival, and mortality for children younger than age 15 years. Cancer. 1986 Jul 15;58(2 Suppl):598–602. doi: 10.1002/1097-0142(19860715)58:2+<598::aid-cncr2820581332>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]

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