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. 1990 Apr;61(4):500–503. doi: 10.1038/bjc.1990.113

Fatty acid control of growth of human cervical and endometrial cancer cells.

R P Gleeson 1, M Ayub 1, J T Wright 1, C B Wood 1, N A Habib 1, W P Soutter 1, M H Sullivan 1, J O White 1
PMCID: PMC1971358  PMID: 2331435

Abstract

Stearic acid and iodo-stearic and inhibited cell growth in a cervical cancer cell line (HOG-1) in a dose-related manner, with a half maximal effect at 50 microM stearic acid. Addition of oleic acid abrogated the effect of stearic acid. EGF-stimulated DNA synthesis and growth of HOG-1 cells was inhibited in the presence of stearic acid without any apparent effect on EGF receptor number or affinity.

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Selected References

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