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. 1990 Feb;61(2):330–334. doi: 10.1038/bjc.1990.65

Chemotherapy for malignant melanoma: combinations and high doses produce more responses without survival benefit.

S Lakhani 1, P Selby 1, J M Bliss 1, T J Perren 1, M E Gore 1, T J McElwain 1
PMCID: PMC1971420  PMID: 1690022

Abstract

In a consecutive series of studies, 164 patients with symptomatic and/or visceral metastatic malignant melanoma were treated with single agent vindesine, high dose melphalan with autologous bone marrow transplantation (AMBT), high dose BCNU with ABMT or the BOLD (bleomycin, vincristine, CCNU and DTIC) combination. The high dose treatments and the combination chemotherapy resulted in significantly higher response rates but no prolongation of survival. Factors associated with longer survival included the absence of visceral metastases, the absence of bulky disease and good performance status. For all treatments, life table estimates of survival at 1 and 2 years were only 10% and 4% respectively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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