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. 1990 Oct;62(4):637–642. doi: 10.1038/bjc.1990.345

Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.

R P Moseley 1, A G Davies 1, R B Richardson 1, M Zalutsky 1, S Carrell 1, J Fabre 1, N Slack 1, J Bullimore 1, B Pizer 1, V Papanastassiou 1, et al.
PMCID: PMC1971477  PMID: 2223581

Abstract

Fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mCi of a 131I radiolabelled monoclonal antibody (MoAb), chosen for its immunoreactivity to tumour. Major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). Nine patients were evaluable for either a tumour or clinical response. Six of these demonstrated an event-free response that was maintained for periods of between 7 and 26 months.

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Selected References

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