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. 1990 Jun;61(6):873–876. doi: 10.1038/bjc.1990.195

An assessment of extensive intraductal component as a risk factor for local recurrence after breast-conserving therapy.

J Jacquemier 1, J M Kurtz 1, R Amalric 1, H Brandone 1, Y Ayme 1, J M Spitalier 1
PMCID: PMC1971685  PMID: 2164836

Abstract

The influence of extensive intraductal component (EIC) on local recurrence risk was studied for 496 patients with stage I-II infiltrating ductal cancers treated by conservative surgery and irradiation. EIC was diagnosed in 65 of 231 (28%) premenopausal and 41 of 265 (15.5%) post-menopausal patients. Local recurrence risk was markedly increased in EIC+ patients (5-year actuarial risk 18% versus 8% without EIC, P less than 0.001), but this effect appeared limited to premenopausal patients. Local recurrence risk increased with increasing degree of EIC. EIC with more than 50% intraductal carcinoma was more prevalent in patients younger than 40, perhaps accounting to some degree for the higher local recurrence rates observed in younger patients. The presence of EIC had no influence on overall survival, on median time to local recurrence, or on short-term survival after local failure. The usefulness of EIC as a risk factor for local recurrence is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartelink H., Borger J. H., van Dongen J. A., Peterse J. L. The impact of tumor size and histology on local control after breast-conserving therapy. Radiother Oncol. 1988 Apr;11(4):297–303. doi: 10.1016/0167-8140(88)90200-9. [DOI] [PubMed] [Google Scholar]
  2. Calle R., Vilcoq J. R., Zafrani B., Vielh P., Fourquet A. Local control and survival of breast cancer treated by limited surgery followed by irradiation. Int J Radiat Oncol Biol Phys. 1986 Jun;12(6):873–878. doi: 10.1016/0360-3016(86)90379-2. [DOI] [PubMed] [Google Scholar]
  3. Fisher E. R., Gregorio R. M., Fisher B., Redmond C., Vellios F., Sommers S. C. The pathology of invasive breast cancer. A syllabus derived from findings of the National Surgical Adjuvant Breast Project (protocol no. 4). Cancer. 1975 Jul;36(1):1–85. doi: 10.1002/1097-0142(197507)36:1<1::aid-cncr2820360102>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  4. Fisher E. R., Sass R., Fisher B., Gregorio R., Brown R., Wickerham L. Pathologic findings from the National Surgical Adjuvant Breast Project (protocol 6). II. Relation of local breast recurrence to multicentricity. Cancer. 1986 May 1;57(9):1717–1724. doi: 10.1002/1097-0142(19860501)57:9<1717::aid-cncr2820570902>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  5. Fourquet A., Campana F., Zafrani B., Mosseri V., Vielh P., Durand J. C., Vilcoq J. R. Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. Int J Radiat Oncol Biol Phys. 1989 Oct;17(4):719–725. doi: 10.1016/0360-3016(89)90057-6. [DOI] [PubMed] [Google Scholar]
  6. Gilchrist K. W., Kalish L., Gould V. E., Hirschl S., Imbriglia J. E., Levy W. M., Patchefsky A. S., Penner D. W., Pickren J., Roth J. A. Interobserver reproducibility of histopathological features in stage II breast cancer. An ECOG study. Breast Cancer Res Treat. 1985;5(1):3–10. doi: 10.1007/BF01807642. [DOI] [PubMed] [Google Scholar]
  7. Harris J. R., Connolly J. L., Schnitt S. J., Cady B., Love S., Osteen R. T., Patterson W. B., Shirley R., Hellman S., Cohen R. B. The use of pathologic features in selecting the extent of surgical resection necessary for breast cancer patients treated by primary radiation therapy. Ann Surg. 1985 Feb;201(2):164–169. doi: 10.1097/00000658-198502000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kurtz J. M., Jacquemier J., Torhorst J., Spitalier J. M., Amalric R., Hünig R., Walther E., Harder F., Almendral A., Brandone H. Conservation therapy for breast cancers other than infiltrating ductal carcinoma. Cancer. 1989 Apr 15;63(8):1630–1635. doi: 10.1002/1097-0142(19890415)63:8<1630::aid-cncr2820630833>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  9. Kurtz J. M., Spitalier J. M., Amalric R., Brandone H., Ayme Y., Bressac C., Hans D. Mammary recurrences in women younger than forty. Int J Radiat Oncol Biol Phys. 1988 Aug;15(2):271–276. doi: 10.1016/s0360-3016(98)90004-9. [DOI] [PubMed] [Google Scholar]
  10. Lindley R., Bulman A., Parsons P., Phillips R., Henry K., Ellis H. Histologic features predictive of an increased risk of early local recurrence after treatment of breast cancer by local tumor excision and radical radiotherapy. Surgery. 1989 Jan;105(1):13–20. [PubMed] [Google Scholar]
  11. Migliori E. Variations according to patient-age in certain histopathological parameters in cancer of the breast. Tumori. 1982 Oct 31;68(5):403–406. doi: 10.1177/030089168206800508. [DOI] [PubMed] [Google Scholar]
  12. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rapin V., Contesso G., Mouriesse H., Bertin F., Lacombe M. J., Piekarski J. D., Travagli J. P., Gadenne C., Friedman S. Medullary breast carcinoma. A reevaluation of 95 cases of breast cancer with inflammatory stroma. Cancer. 1988 Jun 15;61(12):2503–2510. doi: 10.1002/1097-0142(19880615)61:12<2503::aid-cncr2820611219>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  14. Recht A., Connolly J. L., Schnitt S. J., Cady B., Love S., Osteen R. T., Patterson W. B., Shirley R., Silen W., Come S. Conservative surgery and radiation therapy for early breast cancer: results, controversies, and unsolved problems. Semin Oncol. 1986 Dec;13(4):434–449. [PubMed] [Google Scholar]
  15. Recht A., Connolly J. L., Schnitt S. J., Silver B., Rose M. A., Love S., Harris J. R. The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys. 1988 Jan;14(1):3–10. doi: 10.1016/0360-3016(88)90043-0. [DOI] [PubMed] [Google Scholar]
  16. Schnitt S. J., Connolly J. L., Harris J. R., Hellman S., Cohen R. B. Pathologic predictors of early local recurrence in Stage I and II breast cancer treated by primary radiation therapy. Cancer. 1984 Mar 1;53(5):1049–1057. doi: 10.1002/1097-0142(19840301)53:5<1049::aid-cncr2820530506>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  17. Schnitt S. J., Connolly J. L., Khettry U., Mazoujian G., Brenner M., Silver B., Recht A., Beadle G., Harris J. R. Pathologic findings on re-excision of the primary site in breast cancer patients considered for treatment by primary radiation therapy. Cancer. 1987 Feb 15;59(4):675–681. doi: 10.1002/1097-0142(19870215)59:4<675::aid-cncr2820590402>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]

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