Abstract
The risk of cancer in the second degree relatives of a population-based series of children with soft tissue sarcoma was studied in relation to (i) various characteristics in these relatives, (ii) certain clinical features in the index children previously identified as risk factors for cancer in their first degree relatives. Overall there was a non-significant deficit of cancers in the second degree relatives (RR = 0.88) and cancer risk was unrelated to type or site of cancer, type of relative, or to risk factors in the index case. The findings indicate that although the families investigated may include a proportion with the Li-Fraumeni cancer family syndrome, the increased cancer risk already reported in the first degree relatives does not extent to second degree relatives in general.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Birch J. M., Hartley A. L., Blair V., Kelsey A. M., Harris M., Teare M. D., Jones P. H. Cancer in the families of children with soft tissue sarcoma. Cancer. 1990 Nov 15;66(10):2239–2248. doi: 10.1002/1097-0142(19901115)66:10<2239::aid-cncr2820661034>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
- Bürki N., Gencik A., Torhorst J. K., Weber W., Müller H. Familial and histological analyses of 138 breast cancer patients. Breast Cancer Res Treat. 1987 Nov;10(2):159–167. doi: 10.1007/BF01810579. [DOI] [PubMed] [Google Scholar]
- Li F. P., Fraumeni J. F., Jr, Mulvihill J. J., Blattner W. A., Dreyfus M. G., Tucker M. A., Miller R. W. A cancer family syndrome in twenty-four kindreds. Cancer Res. 1988 Sep 15;48(18):5358–5362. [PubMed] [Google Scholar]
- Li F. P., Fraumeni J. F., Jr Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med. 1969 Oct;71(4):747–752. doi: 10.7326/0003-4819-71-4-747. [DOI] [PubMed] [Google Scholar]
- Majumder P. P., Chakraborty R., Weiss K. M. Relative risks of diseases in the presence of incomplete penetrance and sporadics. Stat Med. 1983 Jan-Mar;2(1):13–24. doi: 10.1002/sim.4780020103. [DOI] [PubMed] [Google Scholar]
- Strong L. C., Stine M., Norsted T. L. Cancer in survivors of childhood soft tissue sarcoma and their relatives. J Natl Cancer Inst. 1987 Dec;79(6):1213–1220. [PubMed] [Google Scholar]
- Weiss K. M., Chakraborty R., Majumder P. P., Smouse P. E. Problems in the assessment of relative risk of chronic disease among biological relatives of affected individuals. J Chronic Dis. 1982;35(7):539–551. doi: 10.1016/0021-9681(82)90073-x. [DOI] [PubMed] [Google Scholar]