Abstract
One hundred and sixteen adults with symptoms of acute urinary tract infection were randomly collected into four groups and given single-dose or seven-day treatment with trimethoprim or co-trimoxazole. Of the 105 patients who completed the study, bacterial urinary infection was present in 70 patients (67 per cent). The rates for symptomatic and bacterial cures were high and indistinguishable between the groups, and there was no difference in the rate of recurrence of urinary infection in the six weeks after treatment. Side effects were lower in the group receiving single-dose trimethoprim (P=0.09).
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bailey R. R., Abbott G. D. Treatment of urinary tract infection with a single dose of trimethoprim-sulfamethoxazole. Can Med Assoc J. 1978 Mar 4;118(5):551–552. [PMC free article] [PubMed] [Google Scholar]
- Bailey R. R., Abbott G. D. Treatment of urinary-tract infection with a single dose of amoxycillin. Nephron. 1977;18(6):316–320. doi: 10.1159/000180849. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Pursell R. Double-blind trial to compare ampicillin, cephalexin, co-trimoxazole, and trimethoprim in treatment of urinary infection. Br Med J. 1972 Jun 17;2(5815):673–676. doi: 10.1136/bmj.2.5815.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cartwright K. A., Stanbridge T. N., Cooper J. Comparison of once daily trimethoprim and standard co-trimoxazole in urinary infections. A clinical trial in general practice. Practitioner. 1982 Jan;226(1363):152–156. [PubMed] [Google Scholar]
- Harbord R. B., Grüneberg R. N. Treatment of urinary tract infection with a single dose of amoxycillin, co-trimoxazole, or trimethoprim.. Br Med J (Clin Res Ed) 1981 Nov 14;283(6302):1301–1302. doi: 10.1136/bmj.283.6302.1301. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koch U. J., Schumann K. P., Küchler R., Kewitz H. Efficacy of trimethoprim, sulfamethoxazole and the combination of both in acute urinary tract infection. Clinical and pharmacokinetical studies. Chemotherapy. 1973;19(5):314–321. doi: 10.1159/000221470. [DOI] [PubMed] [Google Scholar]
- Källenius G., Winberg J. Urinary tract infections treated with single dose of short-acting sulphonamide. Br Med J. 1979 May 5;1(6172):1175–1176. doi: 10.1136/bmj.1.6172.1175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lacey R. W., Simpson M. H., Lord V. L., Fawcett C., Button E. S., Luxton D. E., Trotter I. S. Comparison of single-dose trimethoprim with a five-day course for the treatment of urinary tract infections in the elderly. Age Ageing. 1981 Aug;10(3):179–185. doi: 10.1093/ageing/10.3.179. [DOI] [PubMed] [Google Scholar]
- MOND N. C., PERCIVAL A., WILLIAMS J. D., BRUMFITT W. PRESENTATION, DIAGNOSIS, AND TREATMENT OF URINARY-TRACT INFECTIONS IN GENERAL PRACTICE. Lancet. 1965 Mar 6;1(7384):514–516. doi: 10.1016/s0140-6736(65)92020-9. [DOI] [PubMed] [Google Scholar]
- Pead L., Crump J., Maskell R. Staphylococci as urinary pathogens. J Clin Pathol. 1977 May;30(5):427–431. doi: 10.1136/jcp.30.5.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rapoport J., Rees G. A., Willmott N. J., Slack R. C., O'Grady F. W. Treatment of acute urinary tract infection with three doses of co-trimoxazole. Br Med J (Clin Res Ed) 1981 Nov 14;283(6302):1302–1303. doi: 10.1136/bmj.283.6302.1302. [DOI] [PMC free article] [PubMed] [Google Scholar]