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. 1985 Jan;51(1):107–114. doi: 10.1038/bjc.1985.15

Pancreatic carcinogenesis-enhancement by cholecystokinin in the hamster-nitrosamine model.

A G Howatson, D C Carter
PMCID: PMC1976814  PMID: 3966964

Abstract

The role of the pancreaticotrophic hormone cholecystokinin (CCK) in modifying the pancreatic response to carcinogen has been examined in the hamster-nitrosamine pancreatic cancer model. Exogenous CCK, 30 IDU kg-1, stimulated a maximal pancreatic secretory response when given intravenously and caused hypertrophy and hyperplasia of the pancreas when given subcutaneously over a period of 6 weeks (pancreatic wet weight, mg per 100 g body weight, controls 295.6 +/- 61; CCK treated 466.4 +/- 77, P less than 0.001). When the same dose of CCK was given to animals receiving N-nitrosobis (2-oxopropyl)amine (BOP; 5 mg kg-1 weekly) there was a reduction in latency period and increase in induction rate of tumour development (CCK + BOP vs. BOP alone, 12 animals with tumours vs. 2 at 15 weeks; P less than 0.02). These effects are consistent with CCK acting as a co-carcinogen or promoter of pancreatic carcinogenesis in this model.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong B., Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975 Apr 15;15(4):617–631. doi: 10.1002/ijc.2910150411. [DOI] [PubMed] [Google Scholar]
  2. BURTON K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J. 1956 Feb;62(2):315–323. doi: 10.1042/bj0620315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gerchman L. L., Ludlum D. B. The properties of O 6 -methylguanine in templates for RNA polymerase. Biochim Biophys Acta. 1973 May 10;308(2):310–316. doi: 10.1016/0005-2787(73)90160-3. [DOI] [PubMed] [Google Scholar]
  4. Hoffmann D., Hecht S. S., Ornaf R. M., Wynder E. L. N'-nitrosonornicotine in tobacco. Science. 1974 Oct 18;186(4160):265–267. doi: 10.1126/science.186.4160.265. [DOI] [PubMed] [Google Scholar]
  5. Li F. P., Fraumeni J. F., Jr, Mantel N., Miller R. W. Cancer mortality among chemists. J Natl Cancer Inst. 1969 Nov;43(5):1159–1164. [PubMed] [Google Scholar]
  6. MASTER R. W. POSSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES OF KNOWN BASE-TRIPLET SEQUENCES. Nature. 1965 Apr 3;206:93–93. doi: 10.1038/206093b0. [DOI] [PubMed] [Google Scholar]
  7. Mancuso T. F., el-Attar A. A. Cohort study of workers exposed to betanaphthylamine and benzidine. J Occup Med. 1967 Jun;9(6):277–285. [PubMed] [Google Scholar]
  8. Margison G. P., Margison J. M., Montesano R. Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine. Biochem J. 1976 Sep 1;157(3):627–634. doi: 10.1042/bj1570627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Miller J. A. Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. Cancer Res. 1970 Mar;30(3):559–576. [PubMed] [Google Scholar]
  10. Munro H. N., Fleck A. Recent developments in the measurement of nucleic acids in biological materials. A supplementary review. Analyst. 1966 Feb;91(79):78–88. doi: 10.1039/an9669100078. [DOI] [PubMed] [Google Scholar]
  11. Petersen H., Solomon T., Grossman M. I. Effect of chronic pentagastrin, cholecystokinin, and secretin on pancreas of rats. Am J Physiol. 1978 Mar;234(3):E286–E293. doi: 10.1152/ajpendo.1978.234.3.E286. [DOI] [PubMed] [Google Scholar]
  12. Pour P., Althoff J., Krüger F. W., Mohr U. A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine. J Natl Cancer Inst. 1977 May;58(5):1449–1453. doi: 10.1093/jnci/58.5.1449. [DOI] [PubMed] [Google Scholar]
  13. Pour P. Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: ductular cells, including islet cell precursors, as primary progenitor cells of tumors. Am J Pathol. 1978 Feb;90(2):295–316. [PMC free article] [PubMed] [Google Scholar]
  14. Reznik-Schüller H. M., Lijinsky W., Hague B. F., Jr Electron microscopic autoradiography of the pancreas in the hamster treated with tritiated N-nitroso-2,6-dimethylmorpholine. Cancer Res. 1980 Jul;40(7):2245–2251. [PubMed] [Google Scholar]
  15. Ryser H. J. Chemical carcinogenesis. N Engl J Med. 1971 Sep 23;285(13):721–734. doi: 10.1056/NEJM197109232851305. [DOI] [PubMed] [Google Scholar]
  16. Scarpelli D. G., Rao M. S., Subbarao V., Beversluis M., Gurka D. P., Hollenberg P. F. Activation of nitrosamines to mutagens by postmitochondrial fraction of hamster pancreas. Cancer Res. 1980 Jan;40(1):67–74. [PubMed] [Google Scholar]
  17. Wynder E. L. An epidemiological evaluation of the causes of cancer of the pancreas. Cancer Res. 1975 Aug;35(8):2228–2233. [PubMed] [Google Scholar]

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