Abstract
Interactions between the photodynamic effect of haematoporphyrin derivative and hyperthermia are reported. Cells labelled with haematoporphyrin derivative and irradiated with red light were sensitized by heat, particularly when the cells were heated after the exposure to light. It is shown that there is a synergistic interaction between the photodynamic effect and hyperthermia (42.5 and 45 degrees C). Hyperthermia-induced inhibition of the repair of photodynamic damage is suggested as a mechanism for the interaction. The possibility that these findings may be advantageous to cancer therapy is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berenbaum M. C. Criteria for analyzing interactions between biologically active agents. Adv Cancer Res. 1981;35:269–335. doi: 10.1016/s0065-230x(08)60912-4. [DOI] [PubMed] [Google Scholar]
- Christensen T., Sandquist T., Feren K., Waksvik H., Moan J. Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin. Br J Cancer. 1983 Jul;48(1):35–43. doi: 10.1038/bjc.1983.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Joshi D. S., Barendsen G. W., van der Schueren E. Thermal enhancement of the effectiveness of gamma radiation for induction of reproductive death in cultured mammalian cells. Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Sep;34(3):233–243. doi: 10.1080/09553007814550821. [DOI] [PubMed] [Google Scholar]
- Kinsey J. H., Cortese D. A., Neel H. B. Thermal considerations in murine tumor killing using hematoporphyrin derivative phototherapy. Cancer Res. 1983 Apr;43(4):1562–1567. [PubMed] [Google Scholar]
- LIPSON R. L., BALDES E. J. Photosensitivity and heat. Arch Dermatol. 1960 Oct;82:517–520. doi: 10.1001/archderm.1960.01580040035006. [DOI] [PubMed] [Google Scholar]
- Moan J., Christensen T. Photodynamic inactivation of cancer cells in vitro. Effect of irradiation temperature and dose fractionation. Cancer Lett. 1979 May;6(6):331–335. doi: 10.1016/s0304-3835(79)80090-7. [DOI] [PubMed] [Google Scholar]
- Moan J., Pettersen E. O., Christensen T. The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin. Br J Cancer. 1979 Apr;39(4):398–407. doi: 10.1038/bjc.1979.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sapareto S. A., Hopwood L. E., Dewey W. C. Combined effects of X irradiation and hyperthermia on CHO cells for various temperatures and orders of application. Radiat Res. 1978 Feb;73(2):221–233. [PubMed] [Google Scholar]
- Steel G. G., Peckham M. J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys. 1979 Jan;5(1):85–91. doi: 10.1016/0360-3016(79)90044-0. [DOI] [PubMed] [Google Scholar]
- Waldow S. M., Dougherty T. J. Interaction of hyperthermia and photoradiation therapy. Radiat Res. 1984 Feb;97(2):380–385. [PubMed] [Google Scholar]