Abstract
The present investigation shows the effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung carcinogenesis in male Wistar rats. Lung tumours were induced by giving three intratracheal instillations, one week apart, of 10 mg benzo(a)pyrene per instillation. Maximum tumour incidence (100%) and tumour burden per rat was found in rats which were kept on vitamin A deficient diet for 4 weeks prior to the first administration and 8 weeks after the last administration of benzo(a)pyrene. Rats in which vitamin A deficiency was terminated after the last administration of the carcinogen had 83% tumour incidence, whereas corresponding control pairfed animals had 39% incidence of tumours. These data represent the values obtained 32 weeks after the last administered dose of the carcinogen and indicate the role of vitamin A, both in the initiation as well as in the postinitiation phases of lung carcinogenesis.
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- Becking G. C. Vitamin A status and hepatic drug metabolism in the rat. Can J Physiol Pharmacol. 1973 Jan;51(1):6–11. doi: 10.1139/y73-002. [DOI] [PubMed] [Google Scholar]
- Bollag W., Matter A. From vitamin A to retinoids in experimental and clinical oncology: achievements, failures, and outlook. Ann N Y Acad Sci. 1981 Feb 27;359:9–23. doi: 10.1111/j.1749-6632.1981.tb12733.x. [DOI] [PubMed] [Google Scholar]
- Dogra S. C., Khanduja K. L., Gupta M. P., Sharma R. R. Binding of benzo(a)pyrene to DNA in normal and vitamin A deficient rats. Indian J Biochem Biophys. 1984 Apr;21(2):117–120. [PubMed] [Google Scholar]
- Dogra S. C., Khanduja K. L., Gupta M. P., Sharma R. R. Effect of vitamin A deficiency on the pulmonary and hepatic drug-metabolizing enzymes in rat. Enzyme. 1983;30(2):99–104. doi: 10.1159/000469557. [DOI] [PubMed] [Google Scholar]
- Dogra S. C., Khanduja K. L., Sharma R. R. Effect of vitamin A deficiency on the levels of glutathione and glutathione-S-transferase activity in rat lung and liver. Experientia. 1982 Aug 15;38(8):903–904. doi: 10.1007/BF01953643. [DOI] [PubMed] [Google Scholar]
- Harris C. C., Sporn M. B., Kaufman D. G., Smith J. M., Jackson F. E., Saffiotti U. Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo[a]pyrene-Ferric oxide. J Natl Cancer Inst. 1972 Mar;48(3):743–761. [PubMed] [Google Scholar]
- Hayes K. C. On the pathophysiology of vitamin A deficiency. Nutr Rev. 1971 Jan;29(1):3–6. doi: 10.1111/j.1753-4887.1971.tb07206.x. [DOI] [PubMed] [Google Scholar]
- Lotan R. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta. 1980 Mar 12;605(1):33–91. doi: 10.1016/0304-419x(80)90021-9. [DOI] [PubMed] [Google Scholar]
- Miranda C. L., Mukhtar H., Bend J. R., Chhabra R. S. Effects of vitamin A deficiency on hepatic and extrahepatic mixed-function oxidase and epoxide-metabolizing enzymes in guinea pig and rabbit. Biochem Pharmacol. 1979 Sep 15;28(18):2713–2716. doi: 10.1016/0006-2952(79)90552-5. [DOI] [PubMed] [Google Scholar]
- Nettesheim P., Williams M. L. The influence of vitamin A on the susceptibility of the rat lung to 3-methylcholanthrene. Int J Cancer. 1976 Mar 15;17(3):351–357. doi: 10.1002/ijc.2910170311. [DOI] [PubMed] [Google Scholar]
- Rogers A. E., Herndon B. J., Newberne P. M. Induction by dimethylhydrazine of intestinal carcinoma in normal rats and rats fed high or low levels of vitamin A. Cancer Res. 1973 May;33(5):1003–1009. [PubMed] [Google Scholar]
- Siddik Z. H., Drew R., Litterst C. L., Mimnaugh E. G., Sikic B. I., Gram T. E. Hepatic cytochrome P-450-dependent metabolism and enzymatic conjugation of foreign compounds in vitamin A-deficient rats. Pharmacology. 1980;21(6):383–390. doi: 10.1159/000137457. [DOI] [PubMed] [Google Scholar]
- Sporn M. B. Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res. 1976 Jul;36(7 Pt 2):2699–2702. [PubMed] [Google Scholar]