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. 1991 Dec;64(6):1151–1156. doi: 10.1038/bjc.1991.480

Verification of the cause of death in the trial of early detection of breast cancer. UK Trial of Early Detection of Breast Cancer Group. Trial Co-ordinating Centre.

J Chamberlain 1, D Coleman 1, R Ellman 1, S Moss 1
PMCID: PMC1977852  PMID: 1764379

Abstract

The limitations of case review as a means of identifying errors in death certificates among breast cancer patients in a non-randomised trial of screening are illustrated by the findings of this large study. Records of 928 out of 990 deaths were available for review but were very variable in quality. Definite errors were found in 1%, errors were suspected in a further 5% and uncertainty about the cause of death, despite review, was recorded for 27%. The overall bias in reporting breast cancer deaths was less than 1%. It was concluded that the certified underlying cause of death without review provides an adequate endpoint for evaluating breast cancer screening programmes in the UK.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alderson M. R., Meade T. W. Accuracy of diagnosis on death certificates compared with that in hospital records. Br J Prev Soc Med. 1967 Jan;21(1):22–29. doi: 10.1136/jech.21.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Andersson I., Aspegren K., Janzon L., Landberg T., Lindholm K., Linell F., Ljungberg O., Ranstam J., Sigfússon B. Mammographic screening and mortality from breast cancer: the Malmö mammographic screening trial. BMJ. 1988 Oct 15;297(6654):943–948. doi: 10.1136/bmj.297.6654.943. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bauer F. W., Robbins S. L. An autopsy study of cancer patients. I. Accuracy of the clinical diagnoses (1955 to 1965) Boston City Hospital. JAMA. 1972 Sep 25;221(13):1471–1474. doi: 10.1001/jama.221.13.1471. [DOI] [PubMed] [Google Scholar]
  4. Brinkley D., Haybittle J. L., Alderson M. R. Death certification in cancer of the breast. Br Med J (Clin Res Ed) 1984 Aug 25;289(6443):465–467. doi: 10.1136/bmj.289.6443.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cameron H. M., McGoogan E. A prospective study of 1152 hospital autopsies: I. Inaccuracies in death certification. J Pathol. 1981 Apr;133(4):273–283. doi: 10.1002/path.1711330402. [DOI] [PubMed] [Google Scholar]
  6. Collette H. J., Day N. E., Rombach J. J., de Waard F. Evaluation of screening for breast cancer in a non-randomised study (the DOM project) by means of a case-control study. Lancet. 1984 Jun 2;1(8388):1224–1226. doi: 10.1016/s0140-6736(84)91704-5. [DOI] [PubMed] [Google Scholar]
  7. Engel L. W., Strauchen J. A., Chiazze L., Jr, Heid M. Accuracy of death certification in an autopsied population with specific attention to malignant neoplasms and vascular diseases. Am J Epidemiol. 1980 Jan;111(1):99–112. doi: 10.1093/oxfordjournals.aje.a112879. [DOI] [PubMed] [Google Scholar]
  8. Hayward J. L., Meakin J. W., Stewart H. J. Assessment of response and recurrence in breast cancer. Semin Oncol. 1978 Dec;5(4):445–449. [PubMed] [Google Scholar]
  9. Jablon S., Angevine D. M., Matsumoto Y. S., Ishida M. On the signifcance of cause of death as recorded on death certificates in Hiroshima and Nagasaki, Japan. Natl Cancer Inst Monogr. 1966 Jan;19:445–465. [PubMed] [Google Scholar]
  10. Roberts M. M., Alexander F. E., Anderson T. J., Chetty U., Donnan P. T., Forrest P., Hepburn W., Huggins A., Kirkpatrick A. E., Lamb J. Edinburgh trial of screening for breast cancer: mortality at seven years. Lancet. 1990 Feb 3;335(8684):241–246. doi: 10.1016/0140-6736(90)90066-e. [DOI] [PubMed] [Google Scholar]
  11. Tabar L., Fagerberg G., Duffy S. W., Day N. E. The Swedish two county trial of mammographic screening for breast cancer: recent results and calculation of benefit. J Epidemiol Community Health. 1989 Jun;43(2):107–114. doi: 10.1136/jech.43.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tabár L., Fagerberg C. J., Gad A., Baldetorp L., Holmberg L. H., Gröntoft O., Ljungquist U., Lundström B., Månson J. C., Eklund G. Reduction in mortality from breast cancer after mass screening with mammography. Randomised trial from the Breast Cancer Screening Working Group of the Swedish National Board of Health and Welfare. Lancet. 1985 Apr 13;1(8433):829–832. doi: 10.1016/s0140-6736(85)92204-4. [DOI] [PubMed] [Google Scholar]
  13. WAALER E., GRIMSTVEDT M. The clinical diagnoses of the causes of death and their reliability. Acta Pathol Microbiol Scand. 1958;43(4):330–338. doi: 10.1111/j.1699-0463.1958.tb04669.x. [DOI] [PubMed] [Google Scholar]

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