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. 1969 Mar 15;1(5645):663–666. doi: 10.1136/bmj.1.5645.663

Advantages of Aluminium Hydroxide Adsorbed Combined Diphtheria, Tetanus, and Pertussis Vaccines for the Immunization of Infants

N R Butler, M A Voyce, W L Burland, Marjorie L Hilton
PMCID: PMC1982696  PMID: 5774314

Abstract

Three combined triple antigen vaccines were used to inoculate infants receiving primary immunization at 3 to 6 months of age. Laboratory potency and toxicity tests and clinical evaluation again showed that the mouse weight gain test is able to predict which vaccines will give reactions in children. The addition of aluminium hydroxide to the vaccine both increased potency and reduced the tendency to cause reactions. Assays on sera showed that almost all children produced agglutinins to Bordetella pertussis types 1, 2, and 3 when the vaccine contained aluminium hydroxide.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARR M., GLENNY A. T., BUTLER N. R. Immunization of babies with diphtheriatetanus-pertusis prophylactic. Br Med J. 1955 Sep 10;2(4940):635–639. doi: 10.1136/bmj.2.4940.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dolby J. M., Vincent W. A. Characterization of the antibodies responsible for the 'bactericidal activity patterns' of antisera to Bordetella pertussis. Immunology. 1965 May;8(5):499–510. [PMC free article] [PubMed] [Google Scholar]
  3. Kendrick P. L., Eldering G., Dixon M. K., Misner J. Mouse Protection Tests in the Study of Pertussis Vaccine: A Comparative Series Using the Intracerebral Route for Challenge. Am J Public Health Nations Health. 1947 Jul;37(7):803–810. [PMC free article] [PubMed] [Google Scholar]
  4. McFarlan A. M., Topley E., Fisher M. Trial of Whooping-cough Vaccine. Br Med J. 1945 Aug 18;2(4415):205–208. doi: 10.1136/bmj.2.4415.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Muggleton P. W. Vaccines against pertussis. Public Health. 1967 Jul;81(5):252–264. doi: 10.1016/s0033-3506(67)80033-7. [DOI] [PubMed] [Google Scholar]
  6. PERKINS F. T., YETTS R., GAISFORD W. Response of 3-months-old infants to 3 doses of trivalent oral poliomyelitis vaccine. Br Med J. 1963 Jun 15;1(5345):1573–1574. doi: 10.1136/bmj.1.5345.1573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. PITTMAN M., COX C. B. PERTUSSIS VACCINE TESTING FOR FREEDOM-FROM-TOXICITY. Appl Microbiol. 1965 May;13:447–456. doi: 10.1128/am.13.3.447-456.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. PRESTON N. W. EFFECTIVENESS OF PERTUSSIS VACCINES. Br Med J. 1965 Jul 3;2(5452):11–13. doi: 10.1136/bmj.2.5452.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SAUER L. W., TUCKER W. H. Immune responses to diphtheria, tetanus, and pertussis, aluminum phosphate adsorbed. Am J Public Health Nations Health. 1954 Jun;44(6):784–788. doi: 10.2105/ajph.44.6.784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. WILSON A. T., HENDERSON I. R., MOORE E. J., HEYWOOD S. N. WHOOPING-COUGH: DIFFICULTIES IN DIAGNOSIS AND INEFFECTIVENESS OF IMMUNIZATION. Br Med J. 1965 Sep 11;2(5462):623–626. doi: 10.1136/bmj.2.5462.623. [DOI] [PMC free article] [PubMed] [Google Scholar]

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