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. 1969 Apr 26;2(5651):229–231. doi: 10.1136/bmj.2.5651.229

Further Study into Obstructive Jaundice and Ischaemic Renal Damage

M Baum, G A Stirling, J L Dawson
PMCID: PMC1983124  PMID: 5780433

Abstract

Renal ischaemia for one hour in two groups of Gunn rats, one with and the other without bile-duct ligation, produced comparable reversible renal tubular lesions in both groups. Since Gunn rats have an unconjugated hyperbilirubinaemia, which is unaffected by bile-duct ligation, it seems likely that the high levels of bilirubin glucuronide are responsible for sensitizing the renal tubules to ischaemia, possibly by depressing cell respiration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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