Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1969 May 17;2(5654):407–411. doi: 10.1136/bmj.2.5654.407

Drug Resistance and R Factors in the Bowel Bacteria of London Patients before and after Admission to Hospital

Naomi Datta
PMCID: PMC1983307  PMID: 4976456

Abstract

The content of drug-resistant coliform bacteria in faecal specimens collected before admission from patients awaiting non-urgent surgery were compared with specimens collected in hospital. Resistant strains of Escherichia coli were isolated from 52% of preadmission specimens and were present in large numbers in 28%. Tetracycline, sulphonamide, and streptomycin resistance were commonest: 60% of resistant strains carried transmissible R factors and multiple resistance was commoner than single. No characteristically resistant intestinal bacteria of any genera were found in hospital specimens as compared with those from outside.

Full text

PDF
408

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson E. S. Drug resistance in Salmonella typhimurium and its implications. Br Med J. 1968 Aug 10;3(5614):333–339. doi: 10.1136/bmj.3.5614.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson E. S. Origin of transferable drug-resistance factors in the enterobacteriaceae. Br Med J. 1965 Nov 27;2(5473):1289–1291. doi: 10.1136/bmj.2.5473.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Davies J. R., Farrant W. N., Tomlinson A. J. Further studies on the antibiotic resistance of Shigella sonnei. I. Transferable antibiotic resistance. J Hyg (Lond) 1968 Sep;66(3):471–477. doi: 10.1017/s0022172400041334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Davies J. R., Farrant W. N., Tomlinson A. J. Further studies on the antibiotic resistance of Shigella sonnei. II. The acquisition of transferable antibiotic resistance in vivo. J Hyg (Lond) 1968 Sep;66(3):479–487. doi: 10.1017/s0022172400041346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FINLAND M., JONES W. F., Jr, BARNES M. W. Occurrence of serious bacterial infections since introduction of antibacterial agents. J Am Med Assoc. 1959 Aug 29;170:2188–2197. doi: 10.1001/jama.1959.63010180008012. [DOI] [PubMed] [Google Scholar]
  6. Lebek G. Medizinische Aspekte der infektiösen Antibiotika-Resistenz gram-negativer Darmbakterien. Pathol Microbiol (Basel) 1967;30(6):1015–1036. [PubMed] [Google Scholar]
  7. Lewis M. J. Transferable drug resistance and other transferable agents in strains of Escherichia coli from two human populations. Lancet. 1968 Jun 29;1(7557):1389–1393. doi: 10.1016/s0140-6736(68)91973-9. [DOI] [PubMed] [Google Scholar]
  8. Maré I. J. Incidence of R factors among Gram negative bacteria in drug-free human and animal communities. Nature. 1968 Dec 7;220(5171):1046–1047. doi: 10.1038/2201046b0. [DOI] [PubMed] [Google Scholar]
  9. Moorhouse E. C., McKay L. Hospital study of transferable drug resistance. Br Med J. 1968 Jun 22;2(5607):741–742. doi: 10.1136/bmj.2.5607.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Smith H. W. Anti-microbial drugs in animal feeds. Nature. 1968 May 25;218(5143):728–731. doi: 10.1038/218728a0. [DOI] [PubMed] [Google Scholar]
  12. Smith H. W., Halls S. Observations on infective drug resistance in Britain. Br Med J. 1966 Jan 29;1(5482):266–269. doi: 10.1136/bmj.1.5482.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Smith H. W. The incidence of infective drug resistance in strains of Escherichia coli isolated from diseased human beings and domestic animals. J Hyg (Lond) 1966 Dec;64(4):465–474. doi: 10.1017/s0022172400040778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Tatum E. L., Lederberg J. Gene Recombination in the Bacterium Escherichia coli. J Bacteriol. 1947 Jun;53(6):673–684. doi: 10.1128/jb.53.6.673-684.1947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WATANABE T. Infective heredity of multiple drug resistance in bacteria. Bacteriol Rev. 1963 Mar;27:87–115. doi: 10.1128/br.27.1.87-115.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Walton J. R. Infectious drug resistance in Escherichia coli isolated from healthy farm animals. Lancet. 1966 Dec 10;2(7476):1300–1302. doi: 10.1016/s0140-6736(66)91705-3. [DOI] [PubMed] [Google Scholar]
  17. Watanabe T. Infectious drug resistance in enteric bacteria. N Engl J Med. 1966 Oct 20;275(16):888–894. doi: 10.1056/NEJM196610202751607. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES