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. 1984 Jan;81(1):195–199. doi: 10.1111/j.1476-5381.1984.tb10761.x

A new in vivo method for the measurement of repetitive anaphylactic responses in the guinea-pig.

K M Bottomley, S Lewis, T J Rising, A Steward
PMCID: PMC1986952  PMID: 6231073

Abstract

The established Konzett-Rossler bronchorespiratory model has been combined with a unique ovalbumin sensitization procedure to give a novel method to measure anaphylaxis in the anaesthetized guinea-pig. Following antigen challenge, up to eight equal bronchoconstrictor responses to the same dose can be generated from a single animal over a 120 min period. Total inhibition of the anaphylactic response can be elicited by four different classes of compound, namely salbutamol, mepyramine, theophylline and dimaprit. Cromoglycate failed to cause any inhibition. The method is discussed with particular reference to the antigen sensitization procedure, which differs substantially from other regimens previously employed and gives rise to heat labile antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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