Abstract
DNA measurements on biopsy material from 24 squamous cell carcinomas of the oral cavity given preoperative radiotherapy indicate that DNA aneuploid tumours respond better to radiotherapy than do diploid and polyploid tumours. The mean S-phase value was higher (16.1%) for 8 tumours that were eradicated by preoperative radiotherapy than for 13 that did not respond (8.1%). These factors correlated better with the response than did histological and clinical (T) classifications. DNA-ploidy and S-phase estimation can complement the histological diagnosis, and may prove valuable when planning treatment.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bjelkenkrantz K., Stål O., Gröntoft O. A fast and reliable system for microcomputerized DNA cytofluorometry in tumour pathology. Histochemistry. 1983;79(2):145–155. doi: 10.1007/BF00489777. [DOI] [PubMed] [Google Scholar]
- Courdi A., Tubiana M., Chavaudra N., Malaise E. P., Le Fur R. Changes in labeling indices of human tumors after irradiation. Int J Radiat Oncol Biol Phys. 1980 Dec;6(12):1639–1644. doi: 10.1016/0360-3016(80)90245-x. [DOI] [PubMed] [Google Scholar]
- Fettig O., Kaltenbach F. B., Kloke W. D. Der 3 H-Thymidine-Test zur Beurteilung der Strahlensensibilität des Collum-Carcinoms. Arch Gynakol. 1973;213(3):283–292. doi: 10.1007/BF00668037. [DOI] [PubMed] [Google Scholar]
- Friedman M. Aspects of radiation biology and radiation pathology observed during the treatment of cancer in man. The Mackenzie Davidson memorial lecture delivered at the British Institute of Radiology on May 16, 1974. Br J Radiol. 1975 Feb;48(566):81–96. doi: 10.1259/0007-1285-48-566-81. [DOI] [PubMed] [Google Scholar]
- Ganzer U. Beziehungen zwischen dem DNS-verteilungsmuster und der Strahlensensibilität verschiedener Gewebe des Kopf- und Halsbereiches. Cytophotometrische Untersuchungen. Arch Otorhinolaryngol. 1974;206(2):155–172. doi: 10.1007/BF00460405. [DOI] [PubMed] [Google Scholar]
- Grossman I., Kurohara S. S., Webster J. H., George F. W., 3rd The prognostic significance of tumor response during radiotherapy in cervical carcinoma. Radiology. 1973 May;107(2):411–415. doi: 10.1148/107.2.411. [DOI] [PubMed] [Google Scholar]
- Hedley D. W., Friedlander M. L., Taylor I. W., Rugg C. A., Musgrove E. A. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem. 1983 Nov;31(11):1333–1335. doi: 10.1177/31.11.6619538. [DOI] [PubMed] [Google Scholar]
- Klintenberg C., Bjelkenkrantz K., Månsson J. C., Killander D., Nordenskjöld B. 3H-thymidine autoradiography and cytophotometric analysis of needle aspirates from human tumours during radiation therapy, endocrine therapy and chemotherapy. Acta Radiol Oncol. 1985 Mar-Apr;24(2):117–122. doi: 10.3109/02841868509134373. [DOI] [PubMed] [Google Scholar]
- Lederman M. Radiation therapy in cancer of the larynx. JAMA. 1972 Sep 11;221(11):1253–1254. [PubMed] [Google Scholar]
- Lin C. S. [Tumor cell kinetics in uterine cervical carcinoma following irradiation]. Nihon Sanka Fujinka Gakkai Zasshi. 1984 Nov;36(11):2138–2146. [PubMed] [Google Scholar]
- Mäntylä M., Kortekangas A. E., Valavaara R. A., Nordman E. M. Tumour regression during radiation treatment as a guide to prognosis. Br J Radiol. 1979 Dec;52(624):972–977. doi: 10.1259/0007-1285-52-624-972. [DOI] [PubMed] [Google Scholar]
- Nüsse M. Cell cycle kinetics of irradiated synchronous and asynchronous tumor cells with DNA distribution analysis and BrdUrd-Hoechst 33258-technique. Cytometry. 1981 Sep;2(2):70–79. doi: 10.1002/cyto.990020206. [DOI] [PubMed] [Google Scholar]
- Trott K. R. Can tumour response be assessed from a biopsy? Br J Cancer Suppl. 1980 Apr;4:163–170. [PMC free article] [PubMed] [Google Scholar]