Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1986 Sep;54(3):467–473. doi: 10.1038/bjc.1986.199

The sarcoidosis-lymphoma syndrome.

H Brincker
PMCID: PMC2001616  PMID: 3756082

Abstract

Analysis of 17 cases of coexistent sarcoidosis and malignant lymphoproliferative disease, supplemented with 29 similar cases reported in the literature indicates that this association is not fortuitous. In addition, significantly more malignancies other than lymphoma were found in this group of patients. A sarcoidosis-lymphoma syndrome appears to exist in which malignant lympho-proliferative disease develops at least 5.5 times more often than expected in middle-aged patients with chronic active sarcoidosis, possibly as a consequence of the immunologic abnormalities observed in the latter disease.

Full text

PDF
473

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackerman A. B., Flaxman B. A. Granulomatous mycosis fungoides. Br J Dermatol. 1970 Apr;82(4):397–401. doi: 10.1111/j.1365-2133.1970.tb06839.x. [DOI] [PubMed] [Google Scholar]
  2. Atwood W. G., Miller R. C., Nelson C. T. Sarcoidosis and the malignant lymphoreticular diseases. Arch Dermatol. 1966 Aug;94(2):144–151. [PubMed] [Google Scholar]
  3. BUCKLE R. M. Reticulosarcoma complicating sarcoidosis. Tubercle. 1960 Jun;41:213–215. doi: 10.1016/s0041-3879(60)80081-5. [DOI] [PubMed] [Google Scholar]
  4. Brennan N. J., Fennelly J. J., Towers R. P., FitzGerald M. X. Sarcoidosis and lymphoma in the same patient. Postgrad Med J. 1983 Sep;59(695):581–585. doi: 10.1136/pgmj.59.695.581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brincker H. Sarcoid reactions and sarcoidosis in Hodgkin's disease and other malignant lymphomata. Br J Cancer. 1972 Apr;26(2):120–123. doi: 10.1038/bjc.1972.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brincker H., Wilbek E. The incidence of malignant tumours in patients with respiratory sarcoidosis. Br J Cancer. 1974 Mar;29(3):247–251. doi: 10.1038/bjc.1974.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cantwell A. R., Jr Variably acid-fast bacteria in a rare case of coexistent malignant lymphoma and cutaneous sarcoid-like granulomas. Int J Dermatol. 1982 Mar;21(2):99–106. doi: 10.1111/j.1365-4362.1982.tb00512.x. [DOI] [PubMed] [Google Scholar]
  8. Casassus P., Vannetzel J. M., Experton B., Valeyre D., Brun B., Teillet F., Turpin F., Lortholary P., Battesti J. P. Association lymphomes malins sarcoïdose. Nouv Presse Med. 1982 Jul 3;11(31):2339–2342. [PubMed] [Google Scholar]
  9. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 11-1984. Long-standing sarcoidosis with the recent onset of the superior-vena-cava syndrome. N Engl J Med. 1984 Mar 15;310(11):708–716. doi: 10.1056/NEJM198403153101109. [DOI] [PubMed] [Google Scholar]
  10. Daniele R. P., Dauber J. H., Rossman M. D. Immunologic abnormalities in sarcoidosis. Ann Intern Med. 1980 Mar;92(3):406–416. doi: 10.7326/0003-4819-92-3-406. [DOI] [PubMed] [Google Scholar]
  11. Foon K. A., Filderman A., Gale R. P. Histiocytic lymphoma following resolution of sarcoidosis. Med Pediatr Oncol. 1981;9(4):325–331. doi: 10.1002/mpo.2950090404. [DOI] [PubMed] [Google Scholar]
  12. Goldfarb B. L., Cohen S. S. Coexistent disseminated sarcoidosis and Hodgkin's disease. JAMA. 1970 Mar 2;211(9):1525–1528. [PubMed] [Google Scholar]
  13. Horwitz O., Payne P. G., Wilbek E. Epidemiology of sarcoidosis in Denmark. Dan Med Bull. 1967 Jun;14(7):178–182. [PubMed] [Google Scholar]
  14. KISSEL P., DUREUX J. B., RAUBER G., BEUREY J., PETERS A., ANTHOINE D. [Malignant reticulosis and sarcoidosis. Apropos of a case of malignant lymphoreticulosis with histopathological lymph node images of the sarcoid type. Terminal blood invasion by cells of lymphoid aspect]. Ann Med Nancy. 1962 May;1:167–176. [PubMed] [Google Scholar]
  15. Kadin M. E., Glatstein E., Dorfman R. F. Clinicopathologic studies of 117 untreated patients subjected to laparotomy for the staging of Hodgkin's disease. Cancer. 1971 Jun;27(6):1277–1294. doi: 10.1002/1097-0142(197106)27:6<1277::aid-cncr2820270602>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  16. Kahn L. B., Gordon W., Camp R. Florid sarcoid reaction associated with lymphoma of the skin. Cancer. 1974 Apr;33(4):1117–1122. doi: 10.1002/1097-0142(197404)33:4<1117::aid-cncr2820330434>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  17. Khayat D., Jacquillat C., Auclerc G., Auclerc M. F., Weil M., Desprez Curely J. P. Sarcoïdose précédant une maladie de Hodgkin. Nouv Presse Med. 1982 May 8;11(21):1638–1639. [PubMed] [Google Scholar]
  18. Kim H., Dorfman R. F. Morphological studies of 84 untreated patients subjected to laparotomy for the staging of non-Hodgkin's lymphomas. Cancer. 1974 Mar;33(3):657–674. doi: 10.1002/1097-0142(197403)33:3<657::aid-cncr2820330311>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  19. LAMACHE A., CHEVREL M. L., BOUREL M., RICHIER J. L. Poussée maligne mortelle, après traitement cortisonique au cours d'une réticulose à type de sarcoïdose. Bull Mem Soc Med Hop Paris. 1954 Nov 5;70(28-29):1070–1080. [PubMed] [Google Scholar]
  20. Louie S., Schwartz R. S. Immunodeficiency and the pathogenesis of lymphoma and leukemia. Semin Hematol. 1978 Apr;15(2):117–138. [PubMed] [Google Scholar]
  21. McFarland J. P., Kauh Y. C., Luscombe H. A. Sarcoidosis associated with mycosis fungoides. Arch Dermatol. 1978 Jun;114(6):912–915. [PubMed] [Google Scholar]
  22. Myers T. J., Granville N. B., Witter B. A. Hairy cell leukemia and sarcoid. Cancer. 1979 May;43(5):1777–1781. doi: 10.1002/1097-0142(197905)43:5<1777::aid-cncr2820430530>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  23. Neiman R. S. Incidence and importance of splenic sarcoid-like granulomas. Arch Pathol Lab Med. 1977 Oct;101(10):518–521. [PubMed] [Google Scholar]
  24. Ponticelli P., Arganini L., Cionini L. Hodgkin's disease associated with sarcoidosis: case report. Tumori. 1981 Feb 28;67(1):45–51. doi: 10.1177/030089168106700109. [DOI] [PubMed] [Google Scholar]
  25. RABEN A. C., BOGDANOVICH N. K., GOLOCHEVSKAYA V. S. A case of transformation of sarcoidosis into reticulosarcomatosis. Probl Gematol Pereliv Krovi. 1961;6:763–769. [PubMed] [Google Scholar]
  26. RAZIS D. V., DIAMOND H. D., CRAVER L. F. Hodgkin's disease associated with other malignant tumors and certain non-neoplastic diseases. Am J Med Sci. 1959 Sep;238:327–335. doi: 10.1097/00000441-195909000-00009. [DOI] [PubMed] [Google Scholar]
  27. Regdosz R., Mulliez P., Croxo C., Podevin P., Creusy C., Saout J., Crinquette J. Association sarcoidose-lymphome hodgkinien et chylothorax. Presse Med. 1984 Apr 28;13(18):1158–1158. [PubMed] [Google Scholar]
  28. Rosenfelt F., Young W., Lonkey S., Rosenbloom B. Sarcoidosis progressing to lymphoma. Ann Intern Med. 1983 Dec;99(6):878–878. doi: 10.7326/0003-4819-99-6-878_2. [DOI] [PubMed] [Google Scholar]
  29. Silver H. M., Nachnani G., Breslow A. Lymphosarcoma and sarcoidosis. Am Rev Respir Dis. 1967 Aug;96(2):290–295. doi: 10.1164/arrd.1967.96.2.290. [DOI] [PubMed] [Google Scholar]
  30. Stoker T. A., Ellis H. Hodgkin's disease with sarcoid features. Proc R Soc Med. 1971 Jun;64(6):661–661. [PMC free article] [PubMed] [Google Scholar]
  31. Turpin F., Lejeune F., Janel F., Lortholary P., Amouroux J., Gentile A., Le Doussal V., Battesti J. P. Maladie de Besnier-Boeck-Schaumann et lymphadenite angioimmunoblastique. Evolution vers un immuno-blastosarcome. Sem Hop. 1980 Nov 18;56(43-44):1775–1778. [PubMed] [Google Scholar]
  32. Vose B. M., Moore M. Human tumor-infiltrating lymphocytes: a marker of host response. Semin Hematol. 1985 Jan;22(1):27–40. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES