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International Journal of Experimental Pathology logoLink to International Journal of Experimental Pathology
. 1992 Feb;73(1):75–84.

Rapid induction of glomerular lipidosis in APA hamsters by streptozotocin.

J S Han 1, Y Sugawara 1, K Doi 1
PMCID: PMC2002471  PMID: 1533531

Abstract

The pathology of male Syrian hamsters of APA strain which were injected intraperitoneally with 40 mg/kg body weight of streptozotocin (SZ) at 2 months of age was examined. It showed long-lasting prominent hyperglycaemia and hyperlipidaemia with glucosuria and the development of glomerular lipidosis from 1 month after SZ-injection (1 MAI). Glomerular lesions were restricted to the juxtamedullary cortex at 1 MAI and then extended to the subcapsular cortex. At 3 MAI, glomerular lesions were characterized by focal segmental glomerulosclerosis showing segmental expansion of the mesangial area due to an increase of basement membrane-like material and mesangial cells with lipid droplets and foam cells. SZ-induced diabetic APA hamsters will be a useful model for the investigation of glomerular lipidosis and focal segmental glomerulosclerosis.

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