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International Journal of Experimental Pathology logoLink to International Journal of Experimental Pathology
. 1992 Feb;73(1):75–84.

Rapid induction of glomerular lipidosis in APA hamsters by streptozotocin.

J S Han 1, Y Sugawara 1, K Doi 1
PMCID: PMC2002471  PMID: 1533531

Abstract

The pathology of male Syrian hamsters of APA strain which were injected intraperitoneally with 40 mg/kg body weight of streptozotocin (SZ) at 2 months of age was examined. It showed long-lasting prominent hyperglycaemia and hyperlipidaemia with glucosuria and the development of glomerular lipidosis from 1 month after SZ-injection (1 MAI). Glomerular lesions were restricted to the juxtamedullary cortex at 1 MAI and then extended to the subcapsular cortex. At 3 MAI, glomerular lesions were characterized by focal segmental glomerulosclerosis showing segmental expansion of the mesangial area due to an increase of basement membrane-like material and mesangial cells with lipid droplets and foam cells. SZ-induced diabetic APA hamsters will be a useful model for the investigation of glomerular lipidosis and focal segmental glomerulosclerosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Shebeb T., Frohlich J., Magil A. B. Glomerular disease in hypercholesterolemic guinea pigs: a pathogenetic study. Kidney Int. 1988 Feb;33(2):498–507. doi: 10.1038/ki.1988.26. [DOI] [PubMed] [Google Scholar]
  2. Ashall F., Bramwell M. E., Harris H. A new marker for human cancer cells. 1 The Ca antigen and the Ca1 antibody. Lancet. 1982 Jul 3;2(8288):1–6. doi: 10.1016/s0140-6736(82)91150-3. [DOI] [PubMed] [Google Scholar]
  3. Bhathena D. B., Weiss J. H., Holland N. H., McMorrow R. G., Curtis J. J., Lucas B. A., Luke R. G. Focal and segmental glomerular sclerosis in reflux nephropathy. Am J Med. 1980 Jun;68(6):886–892. doi: 10.1016/0002-9343(80)90218-1. [DOI] [PubMed] [Google Scholar]
  4. Brenner B. M., Meyer T. W., Hostetter T. H. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med. 1982 Sep 9;307(11):652–659. doi: 10.1056/NEJM198209093071104. [DOI] [PubMed] [Google Scholar]
  5. Couser W. G., Stilmant M. M. Mesangial lesions and focal glomerular sclerosis in the aging rat. Lab Invest. 1975 Nov;33(5):491–501. [PubMed] [Google Scholar]
  6. Diamond J. R., Karnovsky M. J. Exacerbation of chronic aminonucleoside nephrosis by dietary cholesterol supplementation. Kidney Int. 1987 Nov;32(5):671–677. doi: 10.1038/ki.1987.259. [DOI] [PubMed] [Google Scholar]
  7. Diamond J. R., Karnovsky M. J. Focal and segmental glomerulosclerosis: analogies to atherosclerosis. Kidney Int. 1988 May;33(5):917–924. doi: 10.1038/ki.1988.87. [DOI] [PubMed] [Google Scholar]
  8. Goldszer R. C., Sweet J., Cotran R. S. Focal segmental glomerulosclerosis. Annu Rev Med. 1984;35:429–449. doi: 10.1146/annurev.me.35.020184.002241. [DOI] [PubMed] [Google Scholar]
  9. Gray J. E., van Zwieten M. J., Hollander C. F. Early light microscopic changes in chronic progressive nephrosis in several strains of aging laboratory rats. J Gerontol. 1982 Mar;37(2):142–150. doi: 10.1093/geronj/37.2.142. [DOI] [PubMed] [Google Scholar]
  10. Gröne H. J., Walli A., Gröne E., Niedmann P., Thiery J., Seidel D., Helmchen U. Induction of glomerulosclerosis by dietary lipids. A functional and morphologic study in the rat. Lab Invest. 1989 Mar;60(3):433–446. [PubMed] [Google Scholar]
  11. Hyman L. R., Burkholder P. M. Focal sclerosing glomerulonephropathy with segmental hyalinosis. A clinicopathologic analysis. Lab Invest. 1973 May;28(5):533–544. [PubMed] [Google Scholar]
  12. Keane W. F., Kasiske B. L., O'Donnell M. P. Lipids and progressive glomerulosclerosis. A model analogous to atherosclerosis. Am J Nephrol. 1988;8(4):261–271. doi: 10.1159/000167599. [DOI] [PubMed] [Google Scholar]
  13. Magil A. B., Cohen A. H. Monocytes and focal glomerulosclerosis. Lab Invest. 1989 Oct;61(4):404–409. [PubMed] [Google Scholar]
  14. Maxwell K. O., Wish C., Murphy J. C., Fox J. G. Serum chemistry reference values in two strains of Syrian hamsters. Lab Anim Sci. 1985 Feb;35(1):67–70. [PubMed] [Google Scholar]
  15. Mezza L. E., Quimby F. W., Durham S. K., Lewis R. M. Characterization of spontaneous amyloidosis of Syrian hamsters using the potassium permanganate method. Lab Anim Sci. 1984 Aug;34(4):376–380. [PubMed] [Google Scholar]
  16. Norimatsu M., Doi K., Itagaki S., Honjo K., Mitsuoka T. Glomerular lipidosis in a Syrian hamster of the APA strain. Lab Anim. 1990 Jan;24(1):48–52. doi: 10.1258/002367790780890383. [DOI] [PubMed] [Google Scholar]
  17. Schwartz M. M., Lewis E. J. Focal segmental glomerular sclerosis: the cellular lesion. Kidney Int. 1985 Dec;28(6):968–974. doi: 10.1038/ki.1985.225. [DOI] [PubMed] [Google Scholar]
  18. Shimamura T. Relationship of dietary intake to the development of glomerulosclerosis in obese Zucker rats. Exp Mol Pathol. 1982 Jun;36(3):423–424. doi: 10.1016/0014-4800(82)90071-5. [DOI] [PubMed] [Google Scholar]
  19. Verani R. R., Hawkins E. P. Recurrent focal segmental glomerulosclerosis. A pathological study of the early lesion. Am J Nephrol. 1986;6(4):263–270. doi: 10.1159/000167173. [DOI] [PubMed] [Google Scholar]
  20. Wehner H., Höhn D., Faix-Schade U., Huber H., Walzer P. Glomerular changes in mice with spontaneous hereditary diabetes. Lab Invest. 1972 Sep;27(3):331–340. [PubMed] [Google Scholar]

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